miR-138-5p suppresses glioblastoma cell viability and leads to cell cycle arrest by targeting cyclin D3. Oncol Lett. 2020 Nov;20(5):264 Authors: Wu H, Wang C, Liu Y, Yang C, Liang X, Zhang X, Li X Abstract Although malignant glioblastoma (GBM) treatment has significantly improved in the past few decades, the prognosis of GBM remains unsatisfactory. MicroRNA (miR)-138-5p has been reported as a tumor suppressor in several types of human cancer;...
Wed Sep 30, 2020 13:10
Enhanced anticancer activity and endocytic mechanisms by polymeric nanocarriers of n-butylidenephthalide in leukemia cells. Clin Transl Oncol. 2020 Sep 28;: Authors: Huang XF, Chen PT, Lin YL, Lee MS, Chang KF, Liao KW, Sheu GT, Hsieh MC, Tsai NM Abstract PURPOSE: The purpose of this study was to investigate the antitumor mechanisms of n-butylidenephthalide (BP) and to further examine the delivery efficacy of polycationic liposome containing...
Wed Sep 30, 2020 13:10
[Epigallocatechin gallate induces CHD5 gene demethylation to promote acute myeloid leukemia cell apoptosis in vitro by regulating p19Arf-p53-p21Cip1 signaling pathway]. Nan Fang Yi Ke Da Xue Xue Bao. 2020 Sep 30;40(9):1230-1238 Authors: Wu M, Jiang M, Xue M, Li Q, Cheng B, Huang M, Xu L, Zhang Y Abstract OBJECTIVE: To investigate the mechanism by which epigallocatechin gallate (EGCG) induces CHD5 gene demethylation and promotes the apoptosis...
Wed Sep 30, 2020 13:10
Inflammaging of Female Reproductive System: a Molecular Landscape. Curr Aging Sci. 2020 Sep 29;: Authors: Rodichkina V, Kvetnoy I, Polyakova V, Arutjunyan A, Nasyrov R, Ivanov D Abstract Aging is a complex biological process, a major aspect of which is the accumulation of somatic changes throughout the life. Cellular senescence is a condition in which cells undergo an irreversible cell cycle arrest in response to various cellular stresses....
Wed Sep 30, 2020 13:10
Bacterial cell proliferation: from molecules to cells. FEMS Microbiol Rev. 2020 Sep 29;: Authors: Meunier A, Cornet F, Campos M Abstract Bacterial cell proliferation is highly efficient, both because bacteria grow fast and multiply with a low failure rate. This efficiency is underpinned by the robustness of the cell cycle and its synchronization with cell growth and cytokinesis. Recent advances in bacterial cell biology brought about by single...
Wed Sep 30, 2020 13:10
Developmentally-programmed cellular senescence is conserved and widespread in zebrafish. Aging (Albany NY). 2020 Sep 29;12: Authors: Da Silva-Álvarez S, Guerra-Varela J, Sobrido-Cameán D, Quelle A, Barreiro-Iglesias A, Sánchez L, Collado M Abstract Cellular senescence is considered a stress response imposing a stable cell cycle arrest to restrict the growth of damaged cells. More recently however, cellular senescence was identified during mouse...
Wed Sep 30, 2020 13:10
Discovery of novel steroidal-chalcone hybrids with potent and selective activity against triple-negative breast cancer. Bioorg Med Chem. 2020 Sep 12;28(23):115763 Authors: Hou Q, Lin X, Lu X, Bai C, Wei H, Luo G, Xiang H Abstract A series of novel steroidal-chalcone derivates were designed and synthesized based on the molecular hybridization strategy and further evaluated for their growth inhibitory activity against three human cancer cell...
Wed Sep 30, 2020 13:10
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