A novel mutant 10Ala/Arg together with mutant 144Ser/Arg of Hepatitis B virus X protein involved in Hepatitis B Virus-related hepatocarcinogenesis in HepG2 cell lines

• Amino acid residues 10 and 144 of HBx anchored signature sequence in HCC tissues.• A10R-S144R mutation prolonged G1/S transition via regulation of cell cycle arrest.• A10R/S144R double-mutation decreased Bax expression and inhibited HepG2 apoptosis.

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