Kolokythas et al1 recently published an interesting article regarding the association of salivary biomarkers with bone deterioration. They suggested that using saliva, rather than serum or urine, could be an alternative for future studies of medication-related osteonecrosis of the jaw. Because it is the first report on the use of saliva for the detection of 2 bone turnover–related biomarkers (NTX and B-AP), a deeper look might be necessary:
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