Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com

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Πέμπτη 10 Δεκεμβρίου 2015

OtoRhinoLaryngology & Medicine,New Articles,December 11th,2015


Additional heparin pre-administration improves cardiac glucose metabolism suppression over low carbohydrate diet alone in 18F-FDG-PET imaging

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 8 δευτερόλεπτα
*Purpose:* Adequate suppression of cardiac glucose metabolism increases the interpretability and diagnostic reliability of 18F-FDG-PET studies performed for cardiac inflammation and infection detection. There are no standardized guidelines, though prolonged fasting (>6 h), carbohydrate-restricted diets, fatty meals and heparin loading have all been proposed. The aim of this study was to compare the three preparatory protocols used in our institution. *Methods:* A total of 150 18F-FDG-PET scans were selected and grouped according to three preparatory protocols (50 consecutive scans... περισσότερα »

Pretargeted immunoPET: Overcoming limitations of space and time

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 8 δευτερόλεπτα
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Perfusion Imaging in Clinical Practice: A Multimodality Approach to Tissue Perfusion Analysis

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 8 δευτερόλεπτα
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Pilot Comparison of 68Ga-RM2 PET and 68Ga-PSMA PET in Patients with Biochemically Recurrent Prostate Cancer

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 8 δευτερόλεπτα
Objectives: Glu-NH-CO-NH-Lys-(Ahx)-[68Ga(HBED-CC)] (68Ga-PSMA) is a positron emission tomography (PET) tracer that can detect prostate cancer relapses and metastases by binding to the extracellular domain of PSMA. 68Ga-labeled DOTA-4-amino-1-carboxymethyl-piperidine-D-Phe- Gln-Trp-Ala-Val- Gly-His-Sta-Leu-NH2 (68Ga-RM2) is a synthetic bombesin receptor antagonist that targets gastrin-releasing peptide receptors (GRPr). We present pilot data on the biodistribution of these PET tracers in a small cohort of patients with biochemically recurrent prostate cancer (BCRPC). *Methods:* Sev...περισσότερα »

A Population Based Gaussian Mixture Model Incorporating 18F-FDG-PET and DW-MRI Quantifies Tumor Tissue Classes

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 8 δευτερόλεπτα
The aim of our study was to create a novel Gaussian Mixture Modeling (GMM) pipeline in order to model the complementary information derived from 2-deoxy-2-(18F)-fluoro-D-glucose (18F-FDG)-Positron Emission Tomography (PET) and Diffusion Weighted Magnetic Resonance Imaging (DW-MRI) measurements to separate the tumor microenvironment into relevant tissue compartments and follow the development of these compartments in a longitudinal manner. *Methods:* Serial 18F-FDG-PET and Apparent Diffusion Coefficient (ADC) maps derived from DW-MR images of NCI-H460 xenograft tumors were co-regis... περισσότερα »

Multiparametric analysis of the relationship between tumor hypoxia and perfusion using 18F-FAZA and 15O-H2O PET

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 8 δευτερόλεπτα
18F-fluoroazomycin-arabinoside (18F-FAZA) is a positron emission tomography (PET) tracer of tumor hypoxia. However, as hypoxia often is associated with decreased perfusion, delivery of 18F-FAZA might be compromised, potentially disturbing the association between tissue hypoxia and 18F-FAZA uptake. The aim of this study was to gain insight in the relationship between tumor perfusion and 18F-FAZA uptake. *Methods:* Ten patients diagnosed with advanced non-small cell lung cancer (NSCLC) underwent subsequent dynamic 15 O-H2O and 18F-FAZA PET scans with arterial sampling. Parametric imag... περισσότερα »

A graphene oxide-based FRET sensor for rapid and specific detection of unfolded collagen fragments

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 8 δευτερόλεπτα
Publication date: 15 May 2016 *Source:*Biosensors and Bioelectronics, Volume 79 Author(s): Xiuxia Sun, Jun Fan, Yuping Zhang, Hongli Chen, Yongqing Zhao, Jianxi Xiao The unstructured collagen species plays a critical role in a variety of important biological processes as well as pathological conditions. In order to develop novel diagnosis and therapies for collagen-related diseases, it is essential to construct simple and efficient methods to detect unfolded collagen fragments. We therefore have designed a FITC-labeled collagen mimic triple helical peptide, whose adsorption on the s... περισσότερα »

A novel electrochemical aptasensor for bisphenol A assay based on triple-signaling strategy

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 8 δευτερόλεπτα
[image: alertIcon.gif] Publication date: 15 May 2016 *Source:*Biosensors and Bioelectronics, Volume 79 Author(s): Peng Yu, Yunqing Liu, Xiaohua Zhang, Jiawan Zhou, Erhu Xiong, Xiaoyu Li, Jinhua Chen Based on a triple-signaling strategy, a novel electrochemical aptasensor has been developed for sensitive and selective detection of bisphenol A (BPA). The thiolated ferrocene (Fc)-modified BPA-binding aptamer probe (Fc-P) was immobilized on the gold electrode and then hybridized with the methylene blue (MB)-modified complementary DNA probe (MB-P) to form a rigid double-stranded DNA (ds-... περισσότερα »

High-yield synthesis of strong photoluminescent N-doped carbon nanodots derived from hydrosoluble chitosan for mercury ion sensing via smartphone APP

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 8 δευτερόλεπτα
Publication date: 15 May 2016 *Source:*Biosensors and Bioelectronics, Volume 79 Author(s): Lei Wang, Baoqiang Li, Feng Xu, Xinyao Shi, Demeng Feng, Daqing Wei, Ying Li, Yujie Feng, Yaming Wang, Dechang Jia, Yu Zhou Photoluminescent carbon nanodots (CNDs) have offered considerable potential to be used in biomedical and environmental fields including live cell imaging and heavy metal ion detection due to their superior quantum emission efficiencies, ability to be functionalized using a variety of chemistries and apparent absence of toxicity. However, to date, synthetic yield of CNDs d... περισσότερα »

Diagnosis and Management of Systemic Sclerosis: A Practical Approach

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 8 δευτερόλεπτα
Abstract Systemic sclerosis is a devastating multisystem rheumatologic condition that is characterized by autoimmunity, tissue fibrosis, obliterative vasculopathy and inflammation. Clinical presentation and course of the condition vary greatly, which complicates both diagnosis and corresponding treatment. In this regard, recent advances in disease understanding, both clinically and biochemically, have led to newer classification criteria for systemic sclerosis that are more inclusive than ever before. Still, significant disease modifying therapies do not yet exist for most patients... περισσότερα »

Consensus on Anterior Discluding Stops for OSA Appliances

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 8 δευτερόλεπτα
*(**Keith Thornton, Barry Glassman, John Viviano,* *Jason Tierney, Steve Carstensen,* *Dan Tache, Harry Ball, Kent Smith, Erin Elliott, Les Priemer, Daniel Klauer, Steve Lamberg, Dennis Marangos, Tony Soileau, Christopher Kelly, Shouresh Charkandeh**)* The LinkedIn Discussion Group, *"SleepDisordersDentistry"* has just completed an open discussion on *"**Anterior Discluding Stop Design, What, Why, When, How and Which…* *".* Here is a consensus for all to ponder. *What was asked,* *"**Anterior Discluding Stop Design, some clinicians make only this design and some never make this...περισσότερα »

The Italian Diabetes and Exercise Study 2 (IDES-2): a long-term behavioral intervention for adoption and maintenance of a physically active lifestyle

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 8 δευτερόλεπτα
Background: Physical activity (PA)/exercise have become an integral part of the management of type 2 diabetes mellitus (T2DM). However, current guidelines are difficult to put into action in this population due to a number of barriers, especially the lack of acceptable, feasible, and validated behavioral intervention strategies. The present manuscript reports the rationale, study design and methods, and design considerations of the Italian Diabetes and Exercise Study (IDES)-2, a randomized controlled trial testing the efficacy of a behavior change strategy in increasing total dail... περισσότερα »

Anti-BP180-type mucous membrane pemphigoid immunoglobulin G shows heterogeneity of internalization of BP180/collagen XVII into keratinocyte cytoplasm

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 8 δευτερόλεπτα
Abstract Anti-BP180-type mucous membrane pemphigoid (BP180-MMP) is a rare autoimmune subepidermal blistering disease that targets the C terminus of BP180*/*collagen XVII. Currently, the pathomechanism of BP180-MMP is not well understood. We reported previously that immunoglobulin G (IgG) from patients with bullous pemphigoid (BP) can induce internalization of BP180 via a macropinocytic pathway, which depletes BP180 and weakens epidermal cell–matrix integrity. The purpose of the present study was to elucidate the pathomechanism of BP180-MMP. Immunohistochemistry of biopsy specimens ... περισσότερα »

Simultaneous detection of multiple lower genital tract pathogens by an impedimetric immunochip

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 2 ώρες
[image: S09565663.gif] Publication date: 15 May 2016 *Source:*Biosensors and Bioelectronics, Volume 79 Author(s): Maria Serena Chiriacò, Elisabetta Primiceri, Francesco De Feo, Alessandro Montanaro, Anna Grazia Monteduro, Andrea Tinelli, Marcella Megha, Davide Carati, Giuseppe Maruccio Lower genital tract infections caused by both sexually and not-sexually transmitted pathogens in women are a key public health priority worldwide, especially in developing countries. Since standard analyses are time-consuming, appropriate therapeutic intervention is often neglected or delayed. Lab-on-...περισσότερα »

A graphene oxide-based FRET sensor for rapid and specific detection of unfolded collagen fragments

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 2 ώρες
Publication date: 15 May 2016 *Source:*Biosensors and Bioelectronics, Volume 79 Author(s): Xiuxia Sun, Jun Fan, Yuping Zhang, Hongli Chen, Yongqing Zhao, Jianxi Xiao The unstructured collagen species plays a critical role in a variety of important biological processes as well as pathological conditions. In order to develop novel diagnosis and therapies for collagen-related diseases, it is essential to construct simple and efficient methods to detect unfolded collagen fragments. We therefore have designed a FITC-labeled collagen mimic triple helical peptide, whose adsorption on the s... περισσότερα »

A novel electrochemical aptasensor for bisphenol A assay based on triple-signaling strategy

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 2 ώρες
[image: alertIcon.gif] Publication date: 15 May 2016 *Source:*Biosensors and Bioelectronics, Volume 79 Author(s): Peng Yu, Yunqing Liu, Xiaohua Zhang, Jiawan Zhou, Erhu Xiong, Xiaoyu Li, Jinhua Chen Based on a triple-signaling strategy, a novel electrochemical aptasensor has been developed for sensitive and selective detection of bisphenol A (BPA). The thiolated ferrocene (Fc)-modified BPA-binding aptamer probe (Fc-P) was immobilized on the gold electrode and then hybridized with the methylene blue (MB)-modified complementary DNA probe (MB-P) to form a rigid double-stranded DNA (ds-... περισσότερα »

High-yield synthesis of strong photoluminescent N-doped carbon nanodots derived from hydrosoluble chitosan for mercury ion sensing via smartphone APP

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 2 ώρες
Publication date: 15 May 2016 *Source:*Biosensors and Bioelectronics, Volume 79 Author(s): Lei Wang, Baoqiang Li, Feng Xu, Xinyao Shi, Demeng Feng, Daqing Wei, Ying Li, Yujie Feng, Yaming Wang, Dechang Jia, Yu Zhou Photoluminescent carbon nanodots (CNDs) have offered considerable potential to be used in biomedical and environmental fields including live cell imaging and heavy metal ion detection due to their superior quantum emission efficiencies, ability to be functionalized using a variety of chemistries and apparent absence of toxicity. However, to date, synthetic yield of CNDs d... περισσότερα »

Diagnosis and Management of Systemic Sclerosis: A Practical Approach

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 2 ώρες
Abstract Systemic sclerosis is a devastating multisystem rheumatologic condition that is characterized by autoimmunity, tissue fibrosis, obliterative vasculopathy and inflammation. Clinical presentation and course of the condition vary greatly, which complicates both diagnosis and corresponding treatment. In this regard, recent advances in disease understanding, both clinically and biochemically, have led to newer classification criteria for systemic sclerosis that are more inclusive than ever before. Still, significant disease modifying therapies do not yet exist for most patients... περισσότερα »

Consensus on Anterior Discluding Stops for OSA Appliances

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 2 ώρες
*(**Keith Thornton, Barry Glassman, John Viviano,* *Jason Tierney, Steve Carstensen,* *Dan Tache, Harry Ball, Kent Smith, Erin Elliott, Les Priemer, Daniel Klauer, Steve Lamberg, Dennis Marangos, Tony Soileau, Christopher Kelly, Shouresh Charkandeh**)* The LinkedIn Discussion Group, *"SleepDisordersDentistry"* has just completed an open discussion on *"**Anterior Discluding Stop Design, What, Why, When, How and Which…* *".* Here is a consensus for all to ponder. *What was asked,* *"**Anterior Discluding Stop Design, some clinicians make only this design and some never make this...περισσότερα »

The Italian Diabetes and Exercise Study 2 (IDES-2): a long-term behavioral intervention for adoption and maintenance of a physically active lifestyle

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 2 ώρες
Background: Physical activity (PA)/exercise have become an integral part of the management of type 2 diabetes mellitus (T2DM). However, current guidelines are difficult to put into action in this population due to a number of barriers, especially the lack of acceptable, feasible, and validated behavioral intervention strategies. The present manuscript reports the rationale, study design and methods, and design considerations of the Italian Diabetes and Exercise Study (IDES)-2, a randomized controlled trial testing the efficacy of a behavior change strategy in increasing total dail... περισσότερα »

Anti-BP180-type mucous membrane pemphigoid immunoglobulin G shows heterogeneity of internalization of BP180/collagen XVII into keratinocyte cytoplasm

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 2 ώρες
Abstract Anti-BP180-type mucous membrane pemphigoid (BP180-MMP) is a rare autoimmune subepidermal blistering disease that targets the C terminus of BP180*/*collagen XVII. Currently, the pathomechanism of BP180-MMP is not well understood. We reported previously that immunoglobulin G (IgG) from patients with bullous pemphigoid (BP) can induce internalization of BP180 via a macropinocytic pathway, which depletes BP180 and weakens epidermal cell–matrix integrity. The purpose of the present study was to elucidate the pathomechanism of BP180-MMP. Immunohistochemistry of biopsy specimens ... περισσότερα »

Spatial distribution of osteoblast activating peptide in the rat stomach

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 2 ώρες
Publication date: Available online 10 December 2015 *Source:*Acta Histochemica Author(s): Ahmed E. Noreldin, Maina Sogabe, Yoshiaki Yamano, Masato Uehara, Mohamed A.A. Mahdy, Mohamed A. Elnasharty, Ahmed Sayed-Ahmed, Katsuhiko Warita, Yoshinao Z. Hosaka Osteoblast activating peptide (OBAP) was previously reported to be expressed in the rat stomach and to have a vital role in osteogenesis, but its distribution in rat stomach has not been determined. Thus, the aim of the present study was to identify the cell types expressing OBAP in the rat stomach. The stomachs of twelve 10-to-11-we... περισσότερα »

Greenhouse gas (CO2, CH4, N2O) emissions from soils following afforestation in central China

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 2 ώρες
[image: S13522310.gif] Publication date: February 2016 *Source:*Atmospheric Environment, Volume 126 Author(s): Xiaolin Dou, Wei Zhou, Quanfa Zhang, Xiaoli Cheng The effects of afforestation are of great importance for terrestrial carbon sequestration. However, the consequences of afforestation for greenhouse gas (GHG, CO2, CH4 and N2O) fluxes remain poorly quantified. We investigate the temporal variations in CO2, CH4 and N2O fluxes in afforested soils (implementing woodland and shrubland) and the adjacent uncultivated area in the Danjiangkou Reservoir area of central China. We exami...περισσότερα »

Spatial and temporal variations of spring dust emissions in northern China over the last 30 years

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 2 ώρες
[image: S13522310.gif] Publication date: February 2016 *Source:*Atmospheric Environment, Volume 126 Author(s): Hongquan Song, Kesheng Zhang, Shilong Piao, Shiqiang Wan Dust emissions caused by wind erosion have significant impacts on land degradation, air quality, and climate change. Dust from the arid and semiarid regions of China is a main contributor to atmospheric dust aerosols in East Asia, and their impacts can stretch far beyond the territory of China. Spatial-temporal patterns of dust emissions in China over the last several decades, however, are still lacking, especially du... περισσότερα »

Polycyclic aromatic hydrocarbon adsorption on selected solid particulate matter fractions

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 2 ώρες
[image: S13522310.gif] Publication date: February 2016 *Source:*Atmospheric Environment, Volume 126 Author(s): Frantisek Bozek, Jiri Huzlik, Adam Pawelczyk, Ignac Hoza, Magdalena Naplavova, Jiri Jedlicka This article is directed to evaluating the proportion of polycyclic aromatic hydrocarbons (PAHs) captured on particulate matter (PM) classified as PM2.5–10 and PM2.5, i.e. particulate matter of aerodynamic diameter 2.5–10 μm and 2.5 μm. During three week-long and one 2-day campaigns, 22 paired air samples were taken in parallel of PM10 and PM2.5 fractions inside the Mrázovka tunnel ... περισσότερα »

Effect of bark beetle (Ips typographus L.) attack on bark VOC emissions of Norway spruce (Picea abies Karst.) trees

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 2 ώρες
Publication date: February 2016 *Source:*Atmospheric Environment, Volume 126 Author(s): Rajendra P. Ghimire, Minna Kivimäenpää, Minna Blomqvist, Toini Holopainen, Päivi Lyytikäinen-Saarenmaa, Jarmo K. Holopainen Climate warming driven storms are evident causes for an outbreak of the European spruce bark beetle (Ips typographus L.) resulting in the serious destruction of mature Norway spruce (Picea abies Karst.) forests in northern Europe. Conifer species are major sources of biogenic volatile organic compounds (BVOCs) in the boreal zone. Climate relevant BVOC emissions are expected ... περισσότερα »

Ammonia emissions in Europe, part II: How ammonia emission abatement strategies affect secondary aerosols

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 2 ώρες
Publication date: February 2016 *Source:*Atmospheric Environment, Volume 126 Author(s): Anna M. Backes, Armin Aulinger, Johannes Bieser, Volker Matthias, Markus Quante In central Europe, ammonium sulphate and ammonium nitrate make up a large fraction of fine particles which pose a threat to human health. Most studies on air pollution through particulate matter investigate the influence of emission reductions of sulphur- and nitrogen oxides on aerosol concentration. Here, we focus on the influence of ammonia (NH3) emissions. Emission scenarios have been created on the basis of the im... περισσότερα »

Data from renewable energy assessments for resort islands in the South China Sea

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 2 ώρες
Publication date: March 2016 *Source:*Data in Brief, Volume 6 Author(s): M. Reyasudin Basir Khan, Razali Jidin, Jagadeesh Pasupuleti Renewable energy assessments for resort islands in the South China Sea were conducted that involves the collection and analysis of meteorological and topographic data. The meteorological data was used to assess the PV, wind and hydropower system potentials on the islands. Furthermore, the reconnaissance study for hydro-potentials were conducted through topographic maps in order to determine the potential sites suitable for development of run-of-river h... περισσότερα »

Feedback-Related Potentials in a Gambling Task with Randomised Reward

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 2 ώρες
Publication date: Available online 10 December 2015 *Source:*Data in Brief Author(s): Faisal Mushtaq, Pablo Puente Guillen, Richard M. Wilkie, Mark A. Mon-Williams, Alexandre Schaefer Event-related potentials (ERPs) time-locked to decision outcomes are reported. Participants engaged in a gambling task (see [1] for details] in which they decided between a risky and a safe option (presented as different coloured shapes) on each trial (416 in total). Each decision was accompanied with (fully randomised) feedback about the reward outcome (Win/Loss) and its magnitude (varying as a functi... περισσότερα »

The relation of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and mean platelet volume with the presence and severity of Behçet's syndrome

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 2 ώρες
Publication date: Available online 10 December 2015 *Source:*The Kaohsiung Journal of Medical Sciences Author(s): Sevil Alan, Serpil Tuna, Elif Betül Türkoğlu Behçet's syndrome (BS) is associated with chronic inflammation and endothelial dysfunction. Although there have been extensive investigations on neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) in many diseases, their roles in BS is unclear. The purpose of the present study was to evaluate NLR, PLR, and MPV levels in BS patients and explore their clinical significance. The...περισσότερα »

The relation of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and mean platelet volume with the presence and severity of Behçet's syndrome

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 2 ώρες
Publication date: Available online 10 December 2015 *Source:*The Kaohsiung Journal of Medical Sciences Author(s): Sevil Alan, Serpil Tuna, Elif Betül Türkoğlu Behçet's syndrome (BS) is associated with chronic inflammation and endothelial dysfunction. Although there have been extensive investigations on neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) in many diseases, their roles in BS is unclear. The purpose of the present study was to evaluate NLR, PLR, and MPV levels in BS patients and explore their clinical significance. The...περισσότερα »

A new method for estimating effect size distribution and heritability from genome-wide association summary results

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 3 ώρες
Abstract Accurately estimating the distribution and heritability of SNP effects across the genome could help explain the mystery of missing heritability. In this study, we propose a novel statistical method for estimating the distribution and heritability of SNP effects from genome-wide association studies (GWASs), and compare its performance to several existing methods using both simulations and real data. Specifically, we study the full range of GWAS summary results and link observed *p* values and unobserved effect sizes by (non-central) Chi-square distribution. By modeling the ... περισσότερα »

The Italian Diabetes and Exercise Study 2 (IDES-2): a long-term behavioral intervention for adoption and maintenance of a physically active lifestyle

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 3 ώρες
Background: Physical activity (PA)/exercise have become an integral part of the management of type 2 diabetes mellitus (T2DM). However, current guidelines are difficult to put into action in this population due to a number of barriers, especially the lack of acceptable, feasible, and validated behavioral intervention strategies. The present manuscript reports the rationale, study design and methods, and design considerations of the Italian Diabetes and Exercise Study (IDES)-2, a randomized controlled trial testing the efficacy of a behavior change strategy in increasing total dail... περισσότερα »

Anti-BP180-type mucous membrane pemphigoid immunoglobulin G shows heterogeneity of internalization of BP180/collagen XVII into keratinocyte cytoplasm

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 3 ώρες
Abstract Anti-BP180-type mucous membrane pemphigoid (BP180-MMP) is a rare autoimmune subepidermal blistering disease that targets the C terminus of BP180*/*collagen XVII. Currently, the pathomechanism of BP180-MMP is not well understood. We reported previously that immunoglobulin G (IgG) from patients with bullous pemphigoid (BP) can induce internalization of BP180 via a macropinocytic pathway, which depletes BP180 and weakens epidermal cell–matrix integrity. The purpose of the present study was to elucidate the pathomechanism of BP180-MMP. Immunohistochemistry of biopsy specimens ... περισσότερα »

Spatial distribution of osteoblast activating peptide in the rat stomach

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 3 ώρες
Publication date: Available online 10 December 2015 *Source:*Acta Histochemica Author(s): Ahmed E. Noreldin, Maina Sogabe, Yoshiaki Yamano, Masato Uehara, Mohamed A.A. Mahdy, Mohamed A. Elnasharty, Ahmed Sayed-Ahmed, Katsuhiko Warita, Yoshinao Z. Hosaka Osteoblast activating peptide (OBAP) was previously reported to be expressed in the rat stomach and to have a vital role in osteogenesis, but its distribution in rat stomach has not been determined. Thus, the aim of the present study was to identify the cell types expressing OBAP in the rat stomach. The stomachs of twelve 10-to-11-we... περισσότερα »

Greenhouse gas (CO2, CH4, N2O) emissions from soils following afforestation in central China

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 3 ώρες
[image: S13522310.gif] Publication date: February 2016 *Source:*Atmospheric Environment, Volume 126 Author(s): Xiaolin Dou, Wei Zhou, Quanfa Zhang, Xiaoli Cheng The effects of afforestation are of great importance for terrestrial carbon sequestration. However, the consequences of afforestation for greenhouse gas (GHG, CO2, CH4 and N2O) fluxes remain poorly quantified. We investigate the temporal variations in CO2, CH4 and N2O fluxes in afforested soils (implementing woodland and shrubland) and the adjacent uncultivated area in the Danjiangkou Reservoir area of central China. We exami...περισσότερα »

Spatial and temporal variations of spring dust emissions in northern China over the last 30 years

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 3 ώρες
[image: S13522310.gif] Publication date: February 2016 *Source:*Atmospheric Environment, Volume 126 Author(s): Hongquan Song, Kesheng Zhang, Shilong Piao, Shiqiang Wan Dust emissions caused by wind erosion have significant impacts on land degradation, air quality, and climate change. Dust from the arid and semiarid regions of China is a main contributor to atmospheric dust aerosols in East Asia, and their impacts can stretch far beyond the territory of China. Spatial-temporal patterns of dust emissions in China over the last several decades, however, are still lacking, especially du... περισσότερα »

Polycyclic aromatic hydrocarbon adsorption on selected solid particulate matter fractions

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 3 ώρες
[image: S13522310.gif] Publication date: February 2016 *Source:*Atmospheric Environment, Volume 126 Author(s): Frantisek Bozek, Jiri Huzlik, Adam Pawelczyk, Ignac Hoza, Magdalena Naplavova, Jiri Jedlicka This article is directed to evaluating the proportion of polycyclic aromatic hydrocarbons (PAHs) captured on particulate matter (PM) classified as PM2.5–10 and PM2.5, i.e. particulate matter of aerodynamic diameter 2.5–10 μm and 2.5 μm. During three week-long and one 2-day campaigns, 22 paired air samples were taken in parallel of PM10 and PM2.5 fractions inside the Mrázovka tunnel ... περισσότερα »

Effect of bark beetle (Ips typographus L.) attack on bark VOC emissions of Norway spruce (Picea abies Karst.) trees

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 3 ώρες
Publication date: February 2016 *Source:*Atmospheric Environment, Volume 126 Author(s): Rajendra P. Ghimire, Minna Kivimäenpää, Minna Blomqvist, Toini Holopainen, Päivi Lyytikäinen-Saarenmaa, Jarmo K. Holopainen Climate warming driven storms are evident causes for an outbreak of the European spruce bark beetle (Ips typographus L.) resulting in the serious destruction of mature Norway spruce (Picea abies Karst.) forests in northern Europe. Conifer species are major sources of biogenic volatile organic compounds (BVOCs) in the boreal zone. Climate relevant BVOC emissions are expected ... περισσότερα »

Ammonia emissions in Europe, part II: How ammonia emission abatement strategies affect secondary aerosols

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 3 ώρες
Publication date: February 2016 *Source:*Atmospheric Environment, Volume 126 Author(s): Anna M. Backes, Armin Aulinger, Johannes Bieser, Volker Matthias, Markus Quante In central Europe, ammonium sulphate and ammonium nitrate make up a large fraction of fine particles which pose a threat to human health. Most studies on air pollution through particulate matter investigate the influence of emission reductions of sulphur- and nitrogen oxides on aerosol concentration. Here, we focus on the influence of ammonia (NH3) emissions. Emission scenarios have been created on the basis of the im... περισσότερα »

Data from renewable energy assessments for resort islands in the South China Sea

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 3 ώρες
Publication date: March 2016 *Source:*Data in Brief, Volume 6 Author(s): M. Reyasudin Basir Khan, Razali Jidin, Jagadeesh Pasupuleti Renewable energy assessments for resort islands in the South China Sea were conducted that involves the collection and analysis of meteorological and topographic data. The meteorological data was used to assess the PV, wind and hydropower system potentials on the islands. Furthermore, the reconnaissance study for hydro-potentials were conducted through topographic maps in order to determine the potential sites suitable for development of run-of-river h... περισσότερα »

Feedback-Related Potentials in a Gambling Task with Randomised Reward

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 3 ώρες
Publication date: Available online 10 December 2015 *Source:*Data in Brief Author(s): Faisal Mushtaq, Pablo Puente Guillen, Richard M. Wilkie, Mark A. Mon-Williams, Alexandre Schaefer Event-related potentials (ERPs) time-locked to decision outcomes are reported. Participants engaged in a gambling task (see [1] for details] in which they decided between a risky and a safe option (presented as different coloured shapes) on each trial (416 in total). Each decision was accompanied with (fully randomised) feedback about the reward outcome (Win/Loss) and its magnitude (varying as a functi... περισσότερα »

Spatial distribution of osteoblast activating peptide in the rat stomach

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 3 ώρες
Publication date: Available online 10 December 2015 *Source:*Acta Histochemica Author(s): Ahmed E. Noreldin, Maina Sogabe, Yoshiaki Yamano, Masato Uehara, Mohamed A.A. Mahdy, Mohamed A. Elnasharty, Ahmed Sayed-Ahmed, Katsuhiko Warita, Yoshinao Z. Hosaka Osteoblast activating peptide (OBAP) was previously reported to be expressed in the rat stomach and to have a vital role in osteogenesis, but its distribution in rat stomach has not been determined. Thus, the aim of the present study was to identify the cell types expressing OBAP in the rat stomach. The stomachs of twelve 10-to-11-we... περισσότερα »

Greenhouse gas (CO2, CH4, N2O) emissions from soils following afforestation in central China

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 3 ώρες
[image: S13522310.gif] Publication date: February 2016 *Source:*Atmospheric Environment, Volume 126 Author(s): Xiaolin Dou, Wei Zhou, Quanfa Zhang, Xiaoli Cheng The effects of afforestation are of great importance for terrestrial carbon sequestration. However, the consequences of afforestation for greenhouse gas (GHG, CO2, CH4 and N2O) fluxes remain poorly quantified. We investigate the temporal variations in CO2, CH4 and N2O fluxes in afforested soils (implementing woodland and shrubland) and the adjacent uncultivated area in the Danjiangkou Reservoir area of central China. We exami...περισσότερα »

Spatial and temporal variations of spring dust emissions in northern China over the last 30 years

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 3 ώρες
[image: S13522310.gif] Publication date: February 2016 *Source:*Atmospheric Environment, Volume 126 Author(s): Hongquan Song, Kesheng Zhang, Shilong Piao, Shiqiang Wan Dust emissions caused by wind erosion have significant impacts on land degradation, air quality, and climate change. Dust from the arid and semiarid regions of China is a main contributor to atmospheric dust aerosols in East Asia, and their impacts can stretch far beyond the territory of China. Spatial-temporal patterns of dust emissions in China over the last several decades, however, are still lacking, especially du... περισσότερα »

Polycyclic aromatic hydrocarbon adsorption on selected solid particulate matter fractions

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 3 ώρες
[image: S13522310.gif] Publication date: February 2016 *Source:*Atmospheric Environment, Volume 126 Author(s): Frantisek Bozek, Jiri Huzlik, Adam Pawelczyk, Ignac Hoza, Magdalena Naplavova, Jiri Jedlicka This article is directed to evaluating the proportion of polycyclic aromatic hydrocarbons (PAHs) captured on particulate matter (PM) classified as PM2.5–10 and PM2.5, i.e. particulate matter of aerodynamic diameter 2.5–10 μm and 2.5 μm. During three week-long and one 2-day campaigns, 22 paired air samples were taken in parallel of PM10 and PM2.5 fractions inside the Mrázovka tunnel ... περισσότερα »

Effect of bark beetle (Ips typographus L.) attack on bark VOC emissions of Norway spruce (Picea abies Karst.) trees

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 3 ώρες
Publication date: February 2016 *Source:*Atmospheric Environment, Volume 126 Author(s): Rajendra P. Ghimire, Minna Kivimäenpää, Minna Blomqvist, Toini Holopainen, Päivi Lyytikäinen-Saarenmaa, Jarmo K. Holopainen Climate warming driven storms are evident causes for an outbreak of the European spruce bark beetle (Ips typographus L.) resulting in the serious destruction of mature Norway spruce (Picea abies Karst.) forests in northern Europe. Conifer species are major sources of biogenic volatile organic compounds (BVOCs) in the boreal zone. Climate relevant BVOC emissions are expected ... περισσότερα »

Ammonia emissions in Europe, part II: How ammonia emission abatement strategies affect secondary aerosols

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 3 ώρες
Publication date: February 2016 *Source:*Atmospheric Environment, Volume 126 Author(s): Anna M. Backes, Armin Aulinger, Johannes Bieser, Volker Matthias, Markus Quante In central Europe, ammonium sulphate and ammonium nitrate make up a large fraction of fine particles which pose a threat to human health. Most studies on air pollution through particulate matter investigate the influence of emission reductions of sulphur- and nitrogen oxides on aerosol concentration. Here, we focus on the influence of ammonia (NH3) emissions. Emission scenarios have been created on the basis of the im... περισσότερα »

Data from renewable energy assessments for resort islands in the South China Sea

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 5 ώρες
Publication date: March 2016 *Source:*Data in Brief, Volume 6 Author(s): M. Reyasudin Basir Khan, Razali Jidin, Jagadeesh Pasupuleti Renewable energy assessments for resort islands in the South China Sea were conducted that involves the collection and analysis of meteorological and topographic data. The meteorological data was used to assess the PV, wind and hydropower system potentials on the islands. Furthermore, the reconnaissance study for hydro-potentials were conducted through topographic maps in order to determine the potential sites suitable for development of run-of-river h... περισσότερα »

Feedback-Related Potentials in a Gambling Task with Randomised Reward

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 5 ώρες
Publication date: Available online 10 December 2015 *Source:*Data in Brief Author(s): Faisal Mushtaq, Pablo Puente Guillen, Richard M. Wilkie, Mark A. Mon-Williams, Alexandre Schaefer Event-related potentials (ERPs) time-locked to decision outcomes are reported. Participants engaged in a gambling task (see [1] for details] in which they decided between a risky and a safe option (presented as different coloured shapes) on each trial (416 in total). Each decision was accompanied with (fully randomised) feedback about the reward outcome (Win/Loss) and its magnitude (varying as a functi... περισσότερα »

Endobronchial Valves for Emphysema without Interlobar Collateral Ventilation

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 20 ώρες
Bronchoscopic lung-volume reduction with the use of one-way endobronchial valves has emerged as a potential treatment for patients with severe emphysema. This treatment was previously investigated in the randomized, controlled Endobronchial Valve for Emphysema Palliation Trial (VENT), which showed… from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1Y4hB50 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OUEqFO via IFTTT

Comprehensive pulmonary rehabilitation in home-based online groups: a mixed method pilot study in COPD

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 20 ώρες
Background: Comprehensive multidisciplinary pulmonary rehabilitation is vital in the management of chronic obstructive pulmonary disease (COPD) and is considered for any stage of the disease. Rehabilitation programmes are often centre-based and organised in groups. However, the distance from the patient's home to the centre and lack of transportation may hinder participation. Rehabilitation at home can improve access to care for patients regardless of disease severity. We had previously studied the technology usability and acceptability of a comprehensive home rehabilitation progr... περισσότερα »

A comparison of fallout 236U and 239Pu uptake by Australian vegetation

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 20 ώρες
[image: 1-s2.0-S0265931X15X00130-cov150h.gif] Publication date: January 2016 *Source:*Journal of Environmental Radioactivity, Volume 151, Part 3 Author(s): M.B. Froehlich, M.M.A. Dietze, S.G. Tims, L.K. Fifield The isotopes 236U and 239Pu, both produced during nuclear weapons tests carried out in the 1950s and 1960s, are present in the environment and may be used as tracers for soil erosion studies. Although these radionuclides occur only at ultra-trace levels in nature, they can be readily measured by accelerator mass spectrometry with the 14UD heavy ion accelerator at the Australia...περισσότερα »

The International Conference on Radioecology and Environmental Radioactivity, 2014, (ICRER-2014)

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 20 ώρες
Publication date: January 2016 *Source:*Journal of Environmental Radioactivity, Volume 151, Part 2 Author(s): Per Strand, Justin Brown from Radiology via ola Kala on Inoreader http://ift.tt/1U6wtzj via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1NOg0ui via IFTTT

Main results of the 2012 joint Norwegian–Russian expedition to the dumping sites of the nuclear submarine K-27 and solid radioactive waste in Stepovogo Fjord, Novaya Zemlya

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 20 ώρες
[image: 1-s2.0-S0265931X15X00129-cov150h.gif] Publication date: January 2016 *Source:*Journal of Environmental Radioactivity, Volume 151, Part 2 Author(s): Justin P. Gwynn, Aleksander Nikitin, Viacheslav Shershakov, Hilde Elise Heldal, Bjørn Lind, Hans-Christian Teien, Ole Christian Lind, Rajdeep Singh Sidhu, Gunnar Bakke, Alexey Kazennov, Denis Grishin, Anastasia Fedorova, Oxana Blinova, Ingrid Sværen, Penny Lee Liebig, Brit Salbu, Cato Christian Wendell, Elisabeth Strålberg, Nailja Valetova, Galina Petrenko, Ivan Katrich, Igor Logoyda, Iolanda Osvath, Isabelle Levy, Jean Bartocci,... περισσότερα »

Environmental impact and risk assessments and key factors contributing to the overall uncertainties

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 20 ώρες
[image: 1-s2.0-S0265931X15X00129-cov150h.gif] Publication date: January 2016 *Source:*Journal of Environmental Radioactivity, Volume 151, Part 2 Author(s): Brit Salbu There is a significant number of nuclear and radiological sources that have contributed, are still contributing, or have the potential to contribute to radioactive contamination of the environment in the future. To protect the environment from radioactive contamination, impact and risk assessments are performed prior to or during a release event, short or long term after deposition or prior and after implementation of c... περισσότερα »

Behavior of accidentally released radiocesium in soil–water environment: Looking at Fukushima from a Chernobyl perspective

Αλέξανδρος ΣφακιανάκηςστοMedicine by Sfakianakis G. AlexandrosΠριν από 20 ώρες
[image: 1-s2.0-S0265931X15X00130-cov150h.gif] Publication date: January 2016 *Source:*Journal of Environmental Radioactivity, Volume 151, Part 3 Author(s): A. Konoplev, V. Golosov, G. Laptev, K. Nanba, Y. Onda, T. Takase, Y. Wakiyama, K. Yoshimura Quantitative characteristics of dissolved and particulate radiocesium wash-off from contaminated watersheds after the FDNPP accident are calculated based on published monitoring data. Comparative analysis is provided for radiocesium wash-off parameters and distribution coefficients, Kd, between suspended matter and water in rivers and surfa... περισσότερα »

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Table of Contents

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 21 ώρες
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