PET Imaging of Mitochondrial Complex I with 18F-BCPP-EF in Brain of Parkinsons Disease Model Monkey

¹⁸F-BCPP-EF was applied to assess mitochondrial complex I (MC-I) activity in the brains of Parkinson's disease (PD) model monkeys prepared by MPTP and also presynaptic dopamine parameters. Methods: ¹¹C-β-CFT for the dopamine transporter (DAT), β-¹¹C-L-DOPA, ¹⁸F-FDOPA, or 6-¹¹C-methyl-m-tyrosine (¹¹C-6MemTyr) for dopamine synthesis, or ¹⁸F-BCPP-EF for MC-1 was intravenously injected into normal and MPTP monkeys in order to analyze their uptakes in the striatum. Results: Significant reductions in presynaptic dopamine parameters and MC-I activity were detected in the striatum of MPTP monkeys. Correlations were observed between MC-I activity and DAT as well as between MC-I activity and dopamine synthesis in the striatum. The order of detectability of impaired MC-I activity was ¹¹C-6MemTyr >> β-¹¹C-L-DOPA > ¹⁸F-FDOPA. Conclusion: ¹⁸F-BCPP-EF has potential as a PET probe for the quantitative imaging of MC-1 damage in the living brains of PD model monkeys using PET.

from Medicine via xlomafota13 on Inoreader http://ift.tt/1SkSAV3
via IFTTT

from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1TW0jIE
via IFTTT