Assessment of the efficacy of a topical combination of fipronil-permethrin (Frontline Tri-Act(®)/Frontect(®)) against egg laying and adult emergence of the cat flea (Ctenocephalides felis) in dogs.

Assessment of the efficacy of a topical combination of fipronil-permethrin (Frontline Tri-Act(®)/Frontect(®)) against egg laying and adult emergence of the cat flea (Ctenocephalides felis) in dogs.

Parasite. 2016;23:57

Authors: Beugnet F, Halos L, Lebon W, Liebenberg J

Abstract
This study was conducted to assess the prevention of egg laying and the inhibition of the emergence of the cat flea (Ctenocephalides felis) resulting from the application of a combination of fipronil and permethrin (Frontline Tri-Act(®)/Frontect(®), Merial) on dogs. Sixteen healthy dogs were included after pre-treatment live flea counts and randomly allocated to two groups. Eight dogs served as untreated controls and 8 dogs were treated on Day 0 and Day 30 with topical application of fipronil/permethrin at the minimum dose of 6.76 mg/kg fipronil and 50.48 mg/kg permethrin. On days -2, 7, 21, 28, 42 and 56, each dog was infested with 100 fleas. Flea eggs were collected from each dog in individual trays from 12 to 36 h after treatment or each flea re-infestation. All fleas were removed by combing and counted 36 h after treatment or infestations. The collected eggs were counted and incubated for 28 days for larval development and adult emergence assessment. The curative efficacy of Frontline Tri-Act(®)/Frontect(®) against adult fleas 36 h after treatment was 95.3% and the efficacy remained 100% after subsequent flea infestations for 8 weeks. Compared to the control group, the treatment reduced egg laying by 84.5% within 36 h after first treatment and was 99.9%, 100%, 100%, 100%, 100% on collection days 7, 21, 29, 43 and 57, respectively. Frontline Tri-Act(®)/Frontect(®) reduced by 28.7% the emergence of new adult fleas from eggs laid during the 48 h of pre-treatment infestation. The inhibition of adult emergence from incubated flea eggs could not be assessed after flea re-infestation in the treated group as no eggs were collected.

PMID: 27991415 [PubMed - in process]

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