One Niche to Rule Both Maintenance and Loss of Stemness in HSCs

Publication date: 20 December 2016
Source:Immunity, Volume 45, Issue 6
Author(s): Motonari Kondo
Hemato-lymphopoiesis initiated by hematopoietic stem cells (HSCs) is tightly regulated by factors present in the bone marrow (BM) niche. Using genetically modified mice, Gomes et al. (2016) show that IL-7 is produced by HSC niche-forming cells and find that the same niche that controls HSC self-renewal can also support differentiation.

Teaser

Hemato-lymphopoiesis initiated by hematopoietic stem cells (HSCs) is tightly regulated by factors present in the bone marrow (BM) niche. Using genetically modified mice, Gomes et al. (2016) show that IL-7 is produced by HSC niche-forming cells and find that the same niche that controls HSC self-renewal can also support differentiation.


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