Sifting through CD8+ T Cell Memory

Publication date: 20 December 2016
Source:Immunity, Volume 45, Issue 6
Author(s): Matthew D. Martin, Vladimir P. Badovinac
In this issue of Immunity, Gerlach et al. (2016) describe three distinct memory CD8⁺ T cell subsets based upon expression of the fractalkine receptor CX3CR1. Their findings revise the paradigm of effector and central memory T cells by revealing a subset of CD8⁺ memory T cells defined by intermediate levels of expression of CX3CR1 that conducts tissue surveillance.

Teaser

In this issue of Immunity, Gerlach et al. (2016) describe three distinct memory CD8⁺ T cell subsets based upon expression of the fractalkine receptor CX3CR1. Their findings revise the paradigm of effector and central memory T cells by revealing a subset of CD8⁺ memory T cells defined by intermediate levels of expression of CX3CR1 that conducts tissue surveillance.


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