Immune Cell Intolerance for Excess Cholesterol

Publication date: 20 December 2016
Source:Immunity, Volume 45, Issue 6
Author(s): Scott B. Widenmaier, Gökhan S. Hotamışlıgil
Chronic metabolic challenges have severe consequences on physiological systems. In this issue of Immunity, Ito et al. (2016) show that defects in cholesterol metabolism in CD11c⁺ immune cells result in impaired antigen presentation and ultimately in autoimmune disease.

Teaser

Chronic metabolic challenges have severe consequences on physiological systems. In this issue of Immunity, Ito et al. (2016) show that defects in cholesterol metabolism in CD11c⁺ immune cells result in impaired antigen presentation and ultimately in autoimmune disease.


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