Publication date: February 2017
Source:Biomedicine & Pharmacotherapy, Volume 86
Author(s): Bo Sheng, Lei Zhao, Xuefeng Zang, Jie Zhen, Wei Chen
Accumulating evidences have confirmed that miRNAs have important roles in sepsis. Myeloid-derived suppressor cells (MDSCs) enhance late sepsis development through immunosuppression in mice. Here, the functions and mechanisms of miR-375 in sepsis were revealed. We found that miR-375 level was downregulated but miR-21 level was upregulated in sepsis patients and that their levels were correlated negatively. Importantly, ectopic expression of miR-375 could decrease the number of sepsis Gr1+CD11b+ MDSCs in mice. Mechanistically, miR-375 could target Janus kinase 2 (JAK2) and further impaired signal transducer and activator of transcription 3 (STAT3) in sepsis Gr1+CD11b+ MDSC. Gain and loss of function of experiments showed that upregulation or downregulation of miR-375 level could decrease or increase miR-21 level. Moreover, pretreatment of JAK2 overexpressing vector could abolish the effects of miR-375 on miR-21 level and the amount of sepsis Gr1+CD11b+ MDSCs. Therefore, our results demonstrate that miR-375 could block JAK2-STAT3 pathway and thus modulate miR-21 level, which is involved in regulation of late sepsis.
http://ift.tt/2hnRqIK
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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miR-375 ameliorates sepsis by downregulating miR-21 level via inhibiting JAK2-STAT3 signaling
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- Letter Response to Dr. Putterman Regarding the Art...
- "Commentary To: Use of ADM in Breast Surgery: our ...
- Re: Complications of Vertical Medial Thigh Lift in...
- Reply: Superomedial versus Inferior Pedicle Reduct...
- Use of ADM in Breast Surgery: our experience and a...
- Inadequate enoxaparin dosing predicts 90-day venou...
- Reply: Concomitant Liposuction Reduces Complicatio...
- Modified lipoabdominoplasty: updating concepts. Ou...
- Cultural Differences in Pretarsal Fullness Accepta...
- Microsurgical Reconstruction of Traumatic Lower Ex...
- A Comparison of Superomedial versus Inferior Pedic...
- BREAST-Q following breast reconstruction: analysis...
- 5-Fluorouracil 0.5%/Salicylic Acid 10%
- Management of Carotid Body Tumor in pediatric pati...
- Topical corticosteroids (TCSs) or topical calcineu...
- Oral 30% glucose provides sufficient sedation in n...
- Hypothyroid-induced acute compartment syndrome in ...
- Splenic injury following elective colonoscopy: a r...
- Rare small intestinal volvulus from entrapment in ...
- Breast, prostate, and thyroid cancer screening tes...
- Age-Related Reduction of Contractile Responses to ...
- Single Point Mutations in Pediatric Differentiated...
- Vascular structures in dermal nevi: a reappraisal
- Zika virus infection, issue on dermatological problem
- Single Point Mutations in Pediatric Differentiated...
- Editorial Board/Reviewing Committee
- Early severe acute respiratory distress syndrome: ...
- Early severe acute respiratory distress syndrome: ...
- Comparison of continuous epidural block and contin...
- Dexmedetomidine for attenuating haemodynamic respo...
- Infraclavicular access to the axillary vein — new ...
- Incidence of in-hospital cardiac arrest in Poland
- Clinical outcome of critically ill patients with t...
- Effect of preoperative intravenous oxycodone admin...
- Anaesthesia management for non-cardiac surgery in ...
- Coagulopathy in sepsis — a new look at an old problem
- Isolated lower limb gangrene: a caveat of terlipre...
- Successful retrieval of a knotted Swan-Ganz cathet...
- Hormonal alterations in PCOS and its influence on ...
- Fournier’s gangrene during ACTH therapy
- Central tegmentum tract hyperintensities in pediat...
- Anti-inflammatory effect of the six compounds isol...
- Reduced allergic lung inflammation by root extract...
- Immunogenicity Evaluation of Modified Adenovirus V...
- Three Reviews Highlight Different Aspects of the H...
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- Editorial board
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- Author index
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- The temporalis muscle flap for reconstruction of s...
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- A disposable amperometric dual-sensor for the dete...
- The analysis of proteins and small molecules based...
- An efficient ratiometric fluorescence sensor based...
- Antibiotics mediated facile one-pot synthesis of g...
- A graphene oxide-based strand displacement amplifi...
- A selective and sensitive optical sensor for disso...
- In vitro selection of DNA aptamers targeting β-lac...
- Automated microraft platform to identify and colle...
- Ultrasensitive electrochemical DNA biosensor based...
- Cyanine5-doped silica nanoparticles as ultra-brigh...
- Differential White Matter Involvement Associated w...
- Editorial Board
- The 6-chromanol derivate SUL-109 enables prolonged...
- The Ethics of Human Enhancement: Understanding the...
- The Ballseye programme: a mixed-methods programme ...
- An observational study to assess if automated diab...
- Too Much of a Good Thing? Chronic IFN Fuels Resist...
- Precision Targeting: Mast Cells Wipe Out Infected ...
- Sifting through CD8+ T Cell Memory
- Immune Cell Intolerance for Excess Cholesterol
- Allergen Exposure: When Timing Is Everything
- One Niche to Rule Both Maintenance and Loss of Ste...
- Expanding the Immunology Toolbox: Embracing Public...
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- Inhaled Fine Particles Induce Alveolar Macrophage ...
- Cholesterol Accumulation in CD11c+ Immune Cells Is...
- Impact of AIP and inhibitory G protein alpha 2 pro...
- Cell morphology and growth observation studies on ...
- A new reactive polymethacrylate bearing pendant fu...
- Drug delivery systems for prolonged duration local...
- Tongue Base Schwannoma
- Tongue Base Schwannoma
- Tongue Base Schwannoma
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- Tongue Base Schwannoma
- Optimizing acitretin use in patients with plaque p...
- Effect of different types of therapeutic trauma on...
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- Optimizing acitretin use in patients with plaque p...
- Effect of different types of therapeutic trauma on...
- Narbenkorrektur mit Hyaluronidase-Injektionen
- Narbenkorrektur mit Hyaluronidase-Injektionen
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