Overexpression of the metastasis-associated gene MTA3 correlates with tumor progression and poor prognosis in hepatocellular carcinoma.

Overexpression of the metastasis-associated gene MTA3 correlates with tumor progression and poor prognosis in hepatocellular carcinoma.

J Gastroenterol Hepatol. 2016 Dec 19;:

Authors: Wang C, Li G, Li J, Li J, Li T, Yu J, Qin C

Abstract
BACKGROUND AND AIMS: Hepatocellular carcinoma (HCC) is one of the most common and aggressive cancers in the world. However, there remains a lack of effective diagnostic and treatment markers. We aimed to explore MTA3 protein expression and function in HCC and its relationship with clinicopathological factors.
METHODS: We investigated the expression pattern and clinicopathological significance of metastasis-associated protein 3 (MTA3) in 90 patients with HCC via immunohistochemistry and explored MTA3 function via gene knockdown of MTA3.
RESULTS: MTA3 was overexpressed in HCC cell nuclei and downregulated in HCC cell cytoplasm. The former finding correlated with metastasis (p = 0.010) and poor prognosis (p = 0.018). In addition, deleting MTA3 inhibited HCC cell growth, invasion, and metastasis in vitro, as shown in the colony formation, migration, and wound healing assays.
CONCLUSIONS: These results indicate that MTA3 is an oncogene of HCC, predicts poor prognosis of HCC, and may be a future marker of HCC treatment.

PMID: 27992674 [PubMed - as supplied by publisher]

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