A lightweight feedback-controlled microdrive for chronic neural recordings.

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A lightweight feedback-controlled microdrive for chronic neural recordings.

J Neural Eng. 2017 Jan 10;:

Authors: Jovalekic A, Cave Lopez S, Canopoli A, Ondracek J, Nager A, Vyssotski A, Hahnloser RH

Abstract
OBJECTIVE: Chronic neural recordings have provided many insights into the relationship between neural activity and behavior. We set out to develop a miniaturized motorized microdrive that allows precise electrode positioning despite possibly unreliable motors.
APPROACH: We designed a feedback-based motor control mechanism. It contains an integrated position readout from an array of magnets and a Hall sensor.
MAIN RESULTS: Our extremely lightweight (<1 g) motorized microdrive allows remote positioning of both metal electrodes and glass pipettes along one motorized axis. Target locations can be defined with a range of 6 mm and they can be reached within 1 ��m precision. The incorporated headstage electronics are capable of both extracellular and intracellular recordings. We included a simple mechanism for repositioning electrodes in three dimensions and for replacing them in midst operation. We present neural data from different premotor areas of adult and juvenile zebra fincshes.
SIGNIFICANCE: Our findings show that feedback-based microdrive control requires little extra size and weight, suggesting that feedback-based control can be incorporated into more complex multi-electrode designs.

PMID: 28071593 [PubMed - as supplied by publisher]

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