Reduced effects of age on dopamine D2 receptor levels in physically active adults

Publication date: 1 March 2017
Source:NeuroImage, Volume 148
Author(s): Linh C. Dang, Jaime J. Castrellon, Scott F. Perkins, Nam T. Le, Ronald L. Cowan, David H. Zald, Gregory R. Samanez-Larkin
Physical activity has been shown to ameliorate dopaminergic degeneration in non-human animal models. However, the effects of regular physical activity on normal age-related changes in dopamine function in humans are unknown. Here we present cross-sectional data from forty-four healthy human subjects between 23 and 80 years old, showing that typical age-related dopamine D2 receptor loss, assessed with PET [18F]fallypride, was significantly reduced in physically active adults compared to less active adults.



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