Clinical Validation of a house dust mite environmental challenge chamber model

In this dust mite allergen challenge chamber model a reproducible correlation between allergen concentration and nasal symptoms has been demonstrated. Retest reproducibility of nasal symptoms measured by TNSS and decreased nasal flow quantified by RMM at three different occasions was demonstrated. Inter-chamber variability of nasal symptoms and nasal flow between two different chamber rooms (VCC 2 and VCC3) was determined to be 2.5% (SD 0.2%) and 3.3% (SD of 1.2 and 2.3) respectively. Chamber exposure in this model was safe in mite allergic subjects with controlled asthma.

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