Gingival Crevicular Fluid Levels Of Monocyte Chemoattractant Protein (MCP)-1 in Patients With Aggressive Periodontitis

Abstract

Objectives

The purpose of this study was to investigate the gingival crevicular fluid (GCF) levels of Monocyte Chemoattractant Protein (MCP)-1 in aggressive periodontitis (AgP) and whether GCF MCP-1 levels differ among localized (L) AgP and generalized (G) AgP.

Material and Methods

A total of 160 subjects including, 80 AgP and 80 age and gender matched periodontally healthy (H) controls were recruited in this cross-sectional study (NCT02927704). GCF samples were collected from 160 patients including 50 LAgP, 30 GAgP and 80 H. Volume of GCF was measured by Periotron 8000^® and enzyme-linked immunosorbent assay was used to assess MCP-1 levels.

Results

Compared to H controls, all clinical parameters and total amounts (pg/30 s) of MCP-1 were significantly higher in subjects with LAgP and GAgP (p<0.05). Although concentrations of GCF MCP-1 did not differ between LAgP and GAgP (p>0.05), total amounts of MCP-1 were higher in GAgP than LAgP (p<0.05).

Conclusion

It can be concluded that the total amount of MCP-1 level in GCF may be a potential determinant in AgP subjects. Increased MCP-1 levels in line with the degree of periodontal destruction in GAgP patients reveals that MCP-1 can be used to understand the disease pathogenesis of LAgP and GAgP.

This article is protected by copyright. All rights reserved.

http://ift.tt/2mi582P