Now UCP(rotein), Now You Don’t: UCP1 Is Not Mandatory for Thermogenesis

Publication date: 4 April 2017
Source:Cell Metabolism, Volume 25, Issue 4
Author(s): Ildiko Szabo, Mario Zoratti
Adipocyte-targeted therapies could potentially combat obesity and metabolic disorders; however, our understanding of adipogenesis and the characterization of the various adipose tissues are incomplete. In this issue, Bertholet et al. (2017) report the existence of two types of heat-producing beige-like adipocytes, those with and those without the mitochondrial uncoupling protein 1 (UCP1).

Teaser

Adipocyte-targeted therapies could potentially combat obesity and metabolic disorders; however, our understanding of adipogenesis and the characterization of the various adipose tissues are incomplete. In this issue, Bertholet et al. report the existence of two types of heat-producing beige-like adipocytes, those with and those without the mitochondrial uncoupling protein 1 (UCP1).


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