Prognostic factors in head and neck mucosal malignant melanoma

Publication date: Available online 3 April 2017
Source:Auris Nasus Larynx
Author(s): Şenol Çomoğlu, Beldan Polat, Mehmet Çelik, Bayram Şahin, Necati Enver, Meryem Nesil Keleş, Şule Öztürk Sarı
ObjectivePrimary mucosal malignant melanoma of the head and neck (HN-PMMM) is an aggressive and uncommon neoplasm. Herein, we present a series of 33 patients and the results of treatment, and aimed to determine prognostic factors in HN-PMMM.MethodsPatients who were diagnosed as having HN-PMMM in our reference hospital, between 2005 and 2014 were evaluated. Thirty-three of these patients who had follow-up data were included. Surgical margin status was extracted from the original pathology reports. Archived materials were retrieved for the histopathologic findings: ulceration, necrosis, lymphovascular invasion, perineural invasion, pigmentation, and presence of an in situ component. Mitotic activity was evaluated using phosphohistone H3 (PHH3) immunohistochemical staining.ResultsWe found an association of PHH3 mitotic activity with overall survival in a univariate analysis and to our knowledge, this is the first report among the available case series of HN-PMMM to evaluate mitotic activity using immunohistochemical staining. We also investigated the relationship between multicentricity and locoregional recurrence, which the authors believe is also a first.ConclusionPHH3 mitotic activity can be used a prognostic factor for head and neck mucosal malignant melanoma.



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