Publication date: August 2017
Source:Biomaterials, Volume 137
Author(s): Aniruddha Roy, Yucheng Zhao, Yang Yang, Andras Szeitz, Tara Klassen, Shyh-Dar Li
Treatment options for metastatic and multidrug resistant (MDR) tumors are limited, and most of the chemotherapeutic drugs exhibit low efficacy against MDR cancers. An anti-tubulin agent podophyllotoxin (PPT) displays high potency against MDR tumor cells. However, due to its poor solubility and non-specificity, PPT cannot be used systemically. We have developed a self-assembling nanoparticle dosage form for PPT (named Celludo) by covalently conjugating PPT and polyethylene glycol (PEG) to acetylated carboxymethyl cellulose (CMC-Ac) via ester linkages. Celludo displayed extended blood circulation with an 18-fold prolonged half-life (t1/2), 9000-fold higher area under the curve (AUC), and 1000-fold reduced clearance compared to free PPT. Tumor delivery was 500-fold higher in the Cellduo group compared to free PPT. Against the lung metastatic model of EMT6-AR1, Celludo showed selective localization in the metastatic nodules and increased the median survival to 20 d compared to 6–8 d with docetaxel and PPT treatment. In the intraperitoneal metastatic model of human ovarian NCI-ADR/RES tumor, Celludo prolonged the median survival from 50 d to 70 d, whereas the standard therapy PEGylated liposomal doxorubicin showed no effect. No major toxicity was detected with the Celludo treatment. These results demonstrate that Celludo is effective against metastatic and MDR tumors.
http://ift.tt/2ru0DER
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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- Spatially and chemically resolved source apportion...
- Focal Capillary Dropout Associated With Optic Disc...
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- Pharmacokinetics and safety of vismodegib in patie...
- Ecotoxicological assessment of the impact of fluor...
- Effect of calcium bentonite on Zn and Cu mobility ...
- A facile route for preparation of magnetic biomass...
- Occurrence and fractionation of Cr along the Loush...
- Two important limitations relating to the spiking ...
- Analysis of the environmental issues concerning th...
- The effect of sewage sludge on heavy metal concent...
- The effect of multiple contamination of soil on LM...
- Eco-friendly and cost-effective Ag nanocrystals fa...
- One-pot synthesis of lightly doped Zn 1−x Cu x O a...
- Exogenous phosphatidylcholine supplementation retr...
- Mineralocorticoid receptor associates with pro-inf...
- Additional effects of dietary advanced glycation e...
- Polyfunctionality of bona fide resident lung CD69+...
- Reply
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- Extracellular ATP is a key modulator of alveolar b...
- Hyperlipidemia is involved in apoptosis in rat sub...
- Maintenance of claudin-3 expression and the barrie...
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- Scarlet Fever
- Antioxidant peroxiredoxin 3 expression is regulate...
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- Estrogen Receptor-α36 is Involved in Icaritin Indu...
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- American Board of Dermatology Examination Dates
- Allergic respiratory disease (ARD), setting forth ...
- Cancer incidence in the Western Australian mining ...
- Modelling lung cancer mortality rates from smoking...
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