The differential effects of unihemispheric and bihemispheric tDCS over the inferior frontal gyrus on proactive control

Publication date: Available online 23 August 2017
Source:Neuroscience Research
Author(s): Jorge Leite, Óscar F. Gonçalves, Patrícia Pereira, Niranjan Khadka, Marom Bikson, Felipe Fregni, Sandra Carvalho
This study examined the effects of bihemispheric and unihemispheric transcranial Direct Current Stimulation (tDCS) over the inferior frontal gyrus (IFG) on proactive control.Sixteen participants were randomized to receive (i) bihemispheric tDCS, with a 35cm² anodal electrode of the right IFG and a 35cm² cathode electrode of left IFG or (ii) unihemispheric tDCS, with a 35cm² anodal electrode of the right IFG and a 100cm² electrode of the left IFG or (iii) sham tDCS, while performing a prepotent inhibition task. There were significant speed-accuracy tradeoff effects in terms of switch costs: unihemispheric tDCS significantly decreased the accuracy when compared to bihemispheric, and sham tDCS, while increased response time when comparing to bihemispheric and sham tDCS. The computational model showed a symmetrical field intensity for the bihemispheric tDCS montage, and an asymmetrical for the unihemispheric tDCS montage. This study confirms that unihemispheric tDCS over the rIFG has a significant impact on response inhibition. The lack of results of bihemispheric tDCS brings two important findings for this study: (i) left IFG seems to be also critically associated with inhibitory response control, and (ii) these results highlight the importance of considering the dual effects of tDCS when choosing the electrode montage.



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