Penicillin skin testing

Although approximately 10% of the population carries a label of penicillin allergy, the vast majority of these individuals turn out to be tolerant of penicillins. The rate of positive penicillin skin test reactions in patients with a history of penicillin allergy seems to have been decreasing in the past 2 decades.1,2 For example, Jost et al1 reported a skin test positive rate of 6% from 1993 through 2003 compared with 27% from 1979 through 1992 in consecutive pediatric patients using the same full set of penicillin skin test reagents.

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