Donor Club Cell Secretory Protein G38A Polymorphism is Associated with a Decreased Risk of Primary Graft Dysfunction in the French Cohort in Lung Transplantation (COLT)

AbstractBackgroundClub Cell Secretory Protein (CCSP) G38A polymorphism has recently been involved in lung epithelial susceptibility to external injuries. Lung transplantation (LT) is currently limited by ischemia-reperfusion injury leading to Primary Graft Dysfunction (PGD). We thus hypothesized that donor CCSP G38A polymorphism might impact the risk of PGD following LT.MethodsWe focused on LT included in the French multicentric Cohort in Lung Transplantation (COLT), performed between January 2009 and December 2014, and associated with preoperative blood samples from the donor and the recipient. Characteristics of the donors, recipients, procedures, early and late outcomes were prospectively recorded in COLT. CCSP serum concentration and CCSP gene G38A polymorphism were retrospectively determined in a blind manner. Their association with grade 3 PGD was studied in univariate and multivariate analysis.ResultsThe study group included 104 LT donors and recipients, 84 with grade 0-2 PGD and 20 with grade 3 PGD. Preoperative CCSP serum concentration was significantly higher in the donors (median 22.54ng/mL, IQR:9.6-43.9) than in the recipients (median 7.03ng/mL, IQR:0.89-19.2, p

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