Synthesis of enantiopure antiobesity drug lorcaserin

Publication date: Available online 21 February 2018
Source:Bioorganic & Medicinal Chemistry
Author(s): Ivana Gazic Smilovic, Jerome Cluzeau, Frank Richter, Sven Nerdinger, Erwin Schreiner, Gerhard Laus, Herwig Schottenberger
Acylation of enantiomerically pure (R)-2-(3-chlorophenyl)propan-1-amine using chloroacetyl chloride, followed by borane reduction and aluminum chloride catalyzed cyclization yielded enantiopure lorcaserin.

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