17-hydroxiprogesterone values in healthy preterm infants.

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17-hydroxiprogesterone values in healthy preterm infants.

Colomb Med (Cali). 2017 Dec 30;48(4):161-166

Authors: Mendoza-Rojas VC, Díaz-Martínez LA, Mantilla-Mora G, Contreras-García GA, Mora-Bautista VM, Martínez-Paredes JF, Calderón-Rojas AL, Gómez-Tarazona CA, Pinzón-Mantilla K

Abstract
Introduction: In preterm newborn, problems with the interpretation of 17-OHP may occur.
Objective: Evaluate 17-OHP values in healthy preterm newborns until they reach the corrected gestational age.
Methods: Longitudinal study of 36 preterm infants with 17-OHP evaluation using ELISA from heel blood from 3 to 5 days and thereafter every 2 weeks until the corrected gestational age. Values adjusting multiple variables such as gestational age, birth weight and sex, among others were compared. The results were analyzed against 82 healthy full-term infants.
Results: In the first week of life, early term infants born within less than 34 months of gestational age show 17-OHP values that are much higher than the full term neonates. After a week, the values decrease and stabilize, but are still higher than those of full term neonates and remain so even at the corrected gestational age. (average difference of 63.0%, CI 95%: 11.8%-115.5%). 33.6% (41 samples) of a total of 122 samples taken from preterm infants were higher than 30 ng/mL.
Conclusions: 17-OHP values in early term infants are higher than those in full term neonates and can be related to postnatal adaptive processes. It is suggested that a second screening at the 37th week of corrected age be performed.

PMID: 29662257 [PubMed - in process]

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