A genomic copy number signature predicts radiation exposure in post-Chernobyl breast cancer.

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A genomic copy number signature predicts radiation exposure in post-Chernobyl breast cancer.

Int J Cancer. 2018 Apr 16;:

Authors: Wilke CM, Braselmann H, Hess J, Klymenko SV, Chumak VV, Zakhartseva LM, Bakhanova EV, Walch AK, Selmansberger M, Samaga D, Weber P, Schneider L, Fend F, Bösmüller HC, Zitzelsberger H, Unger K

Abstract
Breast cancer is the second leading cause of cancer death among women worldwide and besides life-style, age and genetic risk factors, exposure to ionising radiation is known to increase the risk for breast cancer. Further, DNA copy number alterations (CNAs), which can result from radiation-induced double-strand breaks, are frequently occurring in breast cancer cells. We set out to identify a signature of CNAs discriminating breast cancers from radiation-exposed and non-exposed female patients. We analysed resected breast cancer tissues from 68 exposed female Chernobyl clean-up workers and evacuees and 68 matched non-exposed control patients for CNAs by array comparative genomic hybridisation analysis (aCGH). Using a stepwise forward-backward selection approach a non-complex CNA-signature, i.e. less than ten features, was identified in the training data set, which could be subsequently validated in the validation data set (p-value<0.05). The signature consisted of nine copy number regions located on chromosomal bands 7q11.22-11.23, 7q21.3, 16q24.3, 17q21.31, 20p11.23-11.21, 1p21.1, 2q35, 2q35, 6p22.2. The signature was independent of any clinical characteristics of the patients. In all, we identified a CNA-signature that has the potential to allow identification of radiation-associated breast cancer at the individual level. This article is protected by copyright. All rights reserved.

PMID: 29663366 [PubMed - as supplied by publisher]

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