Higher cord blood levels of fatty acids in pregnant women with type 1 diabetes mellitus.

Higher cord blood levels of fatty acids in pregnant women with type 1 diabetes mellitus.

J Clin Endocrinol Metab. 2018 May 01;:

Authors: Djelmis J, Ivaniševic M, Desoye G, van Poppel M, Berberovic E, Soldo D, Oreskovic S

Abstract
Context: Type 1 diabetes mellitus is associated with a disturbance of carbohydrate and lipid metabolism.
Objective: To determine whether type 1 diabetes mellitus (T1DM) alters maternal and neonatal fatty acid levels.
Design: Observational study.
Setting: Academic hospital.
Patients: Sixty pregnant women (30 women with T1DM with good glycemic control and 30 healthy women) were included in the study. Maternal blood, umbilical vein and artery blood samples were collected immediately upon delivery. Following lipid extraction, the fatty acid profiles of the total fatty acid pool of maternal serum and umbilical vein and artery serum were determined by gas chromatography.
Results: Total fatty acid concentration in maternal serum did not differ between the study groups; it was significantly higher in umbilical vein serum of the T1DM group compared with that in the control group, median (interquartile range), T1DM: 2126.2 (1446.4 - 3181.3), control: 1073.8 (657.5 - 2226.0); (P<0.001) and in umbilical artery vein serum T1DM: 1805.7 (1393.1 - 2125.0), control: 990.0 (643.3 - 1668.0); (P<0.001). Composition of fatty acids in umbilical vein serum fatty acids showed significantly higher concentrations of saturated, monounsaturated and polyunsaturated fatty acids in the T1DM group than in compared with those in the control group (P=0.001). Also cord blood levels of leptin (P<0.001), C-peptide (P<0.001), and insulin resistance (P=0.015) were higher in the T1DM group compared to controls.
Conclusion: The neonates born to T1DM mothers had higher concentrations of total fatty acids, saturated and monounsaturated fatty acids, as well as polyunsaturated fatty acids, compared to control group newborns.

PMID: 29722816 [PubMed - as supplied by publisher]

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