Association Between BRAFV600E Mutation and the American College of Radiology Thyroid Imaging, Reporting and Data System in Solitary Papillary Thyroid Carcinoma

Publication date: Available online 23 June 2018
Source:Academic Radiology
Author(s): Ronger Shangguan, Yuan-Ping Hu, Jun Huang, Shao-Jun Yang, Ling Ye, Ri-Xu Lin, Jian Zhu, Tong-Long Zhang, Li Ying, Peng Li
Rationale and Objectives: The purpose of this study was to evaluate the associations between BRAF^V600E mutation, the American College of Radiology (ACR) thyroid imaging, reporting and data system (TI-RADS) on ultrasound and clinicopathological characteristics in patients with a solitary papillary thyroid carcinoma (PTC).Materials and Methods: This retrospective study included 397 patients with a solitary PTC, proved pathologically. BRAF^V600E mutation status was detected in postoperative samples by real-time fluorescent polymerase chain reaction. Associations of BRAF^V600E mutation with the ACR TI-RADS and clinicopathological characteristics were analyzed.Results: In this study, the incidence of BRAF^V600E mutation was 81.4% (323/397) in patients with a solitary PTC. Univariate analyses showed that BRAF^V600E mutation was significantly associated with margin, higher ACR TI-RADS point scores, and Hashimoto's thyroiditis. In multivariate analyses, lobulated or irregular margin was independently associated with BRAF^V600E mutation in total solitary PTC. Furthermore, both in total solitary PTC and papillary thyroid microcarcinoma, BRAF^V600E mutation was associated with ACR TI-RADS point scores, which was positively correlated with the risk of BRAF^V600E mutation. There was no significant relationship between BRAF^V600E mutation and ACR TI-RADS point scores in PTC >10mm. In addition, Hashimoto's thyroiditis had a significant negative association with BRAF^V600E mutation.Conclusion: A lobulated or irregular margin of the thyroid nodule is independently associated with BRAF^V600E mutation in patients with PTC. In addition, higher ACR TI-RADS point scores is an independent risk factor for BRAF^V600E mutation, and ACR TI-RADS point scores is positively associated with the risk of BRAF^V600E mutation in solitary PTC, especially in papillary thyroid microcarcinoma. Our findings may be helpful for preoperative identification and medical management of PTC patients with BRAF^V600E mutation.



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