Publication date: Available online 22 June 2018
Source:Radiotherapy and Oncology
Author(s): Liv B. Hysing, Christian Ekanger, Ándras Zolnay, Svein Inge Helle, Mana Rasi, Ben J.M. Heijmen, Marcin Sikora, Matthias Söhn, Ludvig Paul Muren, Sara Thörnqvist
PurposePlanned doses are used as surrogate for the actually delivered dose in radiotherapy. We have estimated the delivered dose in a dose-escalation trial of locally advanced prostate cancer by statistical dose-accumulation and by DVH-summation, and compared to planned dose.Materials and methodPrescribed dose-escalation to the prostate was 67.5 Gy/25fr., corresponding to 81GyEQD2 assuming α/β = 1.5. The 21 patients had three targets (i.e. CTV67.5 + 2 mm, CTV60 + 5 mm, CTV50 + 10 mm) irradiated by a simultaneous-integrated-boost technique. Analysis was based on 213 CT scans and 5-years of follow-up. For statistical dose-accumulation, we modelled 10000 possible treatment courses based on planned dose and deformation-vector-fields from contour-based registration. For DVH-summation we recalculated dose on repeat-CTs and estimated median D98%/EUD. Groups with/without disease recurrence were compared.ResultsDiscrepancies between planned and accumulated dose were mostly seen for CTV67.5, where under-dosage was found at different locations in the prostate in 12/21 patients. Delivered dose-escalation (D98%) was on average 73.9GyEQD2 (range: 68.3–78.7GyEQD2). No significant difference in accumulated-D98% was found in patients with (n = 8) and without (n = 13) recurrence (p > 0.05). Average D98%/EUD with statistical dose-accumulation vs DVH-summation was significantly different in CTV60, CTV50, rectum and bladder but not in CTV67.5.ConclusionThe planned dose escalation was not received by more than half-of-the patients. Robustness of the prostate target (CTV67.5) should therefore be better prioritized in these patients given the low toxicity profile. Estimates of delivered dose were less conservative for dose-accumulation due to interaction of random organ motion with the dose matrix.
https://ift.tt/2MdAiof
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
Αρχειοθήκη ιστολογίου
-
►
2023
(391)
- ► Φεβρουαρίου (200)
- ► Ιανουαρίου (191)
-
►
2022
(2843)
- ► Δεκεμβρίου (161)
- ► Σεπτεμβρίου (219)
- ► Φεβρουαρίου (264)
- ► Ιανουαρίου (280)
-
►
2021
(5625)
- ► Δεκεμβρίου (231)
- ► Σεπτεμβρίου (345)
- ► Φεβρουαρίου (620)
-
►
2020
(2065)
- ► Δεκεμβρίου (535)
- ► Σεπτεμβρίου (222)
- ► Φεβρουαρίου (28)
-
►
2019
(9608)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3791)
- ► Ιανουαρίου (3737)
-
▼
2018
(69720)
- ► Δεκεμβρίου (3507)
- ► Σεπτεμβρίου (3851)
-
▼
Ιουνίου
(5852)
-
▼
Ιουν 23
(158)
- Performance of Electrical Velocimetry for Noninvas...
- Dilated Pupil as a Diagnostic Component of Brain D...
- Dorsal and ventral visual stream contributions to ...
- Relationship between mold exposure, specific IgE s...
- Risk Factors for Multiple Epinephrine Doses in Foo...
- LSECs express functional NOD1 receptors: A role fo...
- LSECs express functional NOD1 receptors: A role fo...
- Clinical and circulating biomarkers of survival an...
- Do SABR-related toxicities for lung cancer depend ...
- Critical review of axillary recurrence in early br...
- Immune-checkpoint inhibitors in non-small cell lun...
- Phasic alertness cues modulate visual processing s...
- Neuronal O-GlcNAc transferase regulates appetite, ...
- Restaurant oil and grease management in Hong Kong
- Characterization of As-polluted soils by laborator...
- Nanodiamond-filled chitosan as an efficient adsorb...
- Dual-emissive ratiometric fluorescent probe based ...
- Versatile graphene biosensors for enhancing human ...
- Silver nanoparticle-induced hormesis of astrogliom...
- Rediscovering Bacteria through Single-Molecule Ima...
- A comparative study on finding an effective root f...
- Nanodiamonds as “artificial proteins”: Regulation ...
- Size-dependent properties of functional PPV-based ...
- Precise temperature sensing with nanoscale thermal...
- Nanomaterials in fluorescent laser-based immunosen...
- Nanodiamond/gold nanorod nanocomposites with tunab...
- Photothermal effects during nanodiamond synthesis ...
- Effective light scattering and charge separation i...
- Emerging trends in 2D nanotechnology that are rede...
- The structural basis for filovirus neutralization ...
- Gratitude intervention modulates P3 amplitude in a...
- The Effect of Exercise on Breast Cancer–Related Ly...
- Relationship between mold exposure, specific IgE s...
- Risk Factors for Multiple Epinephrine Doses in Foo...
- Interoception is associated with heartbeat-evoked ...
- Interoceptive Accuracy Scores from the Heartbeat C...
- Altered neural inhibition responses to food cues a...
- How chronic administration of benzodiazepines lead...
- Plerixafor and related macrocyclic amines are pote...
- Giant congenital melanocytic nevus in a Cameroonia...
- Visuocortical changes during a freezing-like state...
- Detailed somatotopy in primary motor and somatosen...
- Shape responses in a macaque frontal area connecte...
- Self-monitoring in the cerebral cortex: Neural res...
- Topical Application of Photofrin® for Photodynamic...
- Effects of residual speech and auditory deprivatio...
- Exposure to positive peer sentiment about nicotine...
- Borderline personality disorder features and drink...
- Thyroid storm after choking
- Long-term thyroid disorders in pediatric survivors...
- The effect of obesity and insulin resistance on ma...
- Menu labels, for better, and worse? Exploring soci...
- Taste at first (person) sight: Visual perspective ...
- Label reading, numeracy and food & nutrition invol...
- The effect of sugar-sweetened beverage front-of-pa...
- Automated Detection of Electroencephalography Arti...
- Quantification characteristics of digital spiral a...
- Biopsia selectiva del ganglio centinela en cáncer ...
- Impaired anticipatory vision and visuomotor coordi...
- Reply
- Can natural killer cells represent an early life i...
- Cell death cascade and molecular therapy in ADAR2-...
- Mortality of patients examined at a diagnostic cen...
- Identification of differentially expressed protein...
- Effects of epidural anesthesia on postoperative na...
- Ultrasound strain imaging in assessment of false v...
- Multimodality images of myofibroblastoma in the ma...
- Evaluation of association between degree of backgr...
- Turn on ESIPT based chemosensor for histidine: App...
- Glossary
- Immunothérapie et cancer du poumon : nouveaux conc...
- Alcool et poumon : des liaisons dangereuses
- Post-curing in dental resin-based composites
- In vitro degradation of a biodegradable polylactic...
- Correlation of resin viscosity and monomer convers...
- Experimental tricalcium silicate cement induces re...
- Deciphering Drosophila female innate behaviors
- Public health air pollution impacts of pathway opt...
- Tacrolimus for the Treatment of Adults with Psoria...
- Text message intervention to reduce frequency of b...
- Pimecrolimus for the Treatment of Adults with Atop...
- Peer Support Programs for Adults Who Have Experien...
- Inactivation of Planktonic Escherichia coli by Foc...
- Effects of Non-thermal, Non-cavitational Ultrasoun...
- Turn on ESIPT based chemosensor for histidine: App...
- Glossary
- Performances of full cross-validation partial leas...
- Data on horizontally transferred genes in Californ...
- Data set on interactive service quality in higher ...
- Description of long-term monitoring of farmland bi...
- Data from proteomic analysis of bovine Longissimus...
- Data article on institutional framework and busine...
- Adsorption of organic pollutants from real refiner...
- Validation of a drooling questionnaire in Indian c...
- Expression of surfactant Protein-A in the Haemophi...
- Macrocephaly, epilepsy and intracranial cysts: an ...
- Pyrexia of unknown origin: inferior vena cava agen...
- Pregnancy and gastric cancer: diagnostic and treat...
- Delayed leucoencephalopathy after coil embolisatio...
- Pancreatic intraepithelial neoplasia in heterotopi...
-
▼
Ιουν 23
(158)
- ► Φεβρουαρίου (8116)
- ► Ιανουαρίου (7758)
-
►
2017
(111579)
- ► Δεκεμβρίου (7718)
- ► Σεπτεμβρίου (7549)
- ► Φεβρουαρίου (10753)
- ► Ιανουαρίου (10529)
-
►
2016
(16402)
- ► Δεκεμβρίου (7478)
- ► Φεβρουαρίου (900)
- ► Ιανουαρίου (1250)
! # Ola via Alexandros G.Sfakianakis on Inoreader
Η λίστα ιστολογίων μου
Σάββατο 23 Ιουνίου 2018
Statistical motion modelling for robust evaluation of clinically delivered accumulated dose distributions after curative radiotherapy of locally advanced prostate cancer
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Αρχειοθήκη ιστολογίου
-
►
2023
(391)
- ► Φεβρουαρίου (200)
- ► Ιανουαρίου (191)
-
►
2022
(2843)
- ► Δεκεμβρίου (161)
- ► Σεπτεμβρίου (219)
- ► Φεβρουαρίου (264)
- ► Ιανουαρίου (280)
-
►
2021
(5625)
- ► Δεκεμβρίου (231)
- ► Σεπτεμβρίου (345)
- ► Φεβρουαρίου (620)
-
►
2020
(2065)
- ► Δεκεμβρίου (535)
- ► Σεπτεμβρίου (222)
- ► Φεβρουαρίου (28)
-
►
2019
(9608)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3791)
- ► Ιανουαρίου (3737)
-
▼
2018
(69720)
- ► Δεκεμβρίου (3507)
- ► Σεπτεμβρίου (3851)
-
▼
Ιουνίου
(5852)
-
▼
Ιουν 23
(158)
- Performance of Electrical Velocimetry for Noninvas...
- Dilated Pupil as a Diagnostic Component of Brain D...
- Dorsal and ventral visual stream contributions to ...
- Relationship between mold exposure, specific IgE s...
- Risk Factors for Multiple Epinephrine Doses in Foo...
- LSECs express functional NOD1 receptors: A role fo...
- LSECs express functional NOD1 receptors: A role fo...
- Clinical and circulating biomarkers of survival an...
- Do SABR-related toxicities for lung cancer depend ...
- Critical review of axillary recurrence in early br...
- Immune-checkpoint inhibitors in non-small cell lun...
- Phasic alertness cues modulate visual processing s...
- Neuronal O-GlcNAc transferase regulates appetite, ...
- Restaurant oil and grease management in Hong Kong
- Characterization of As-polluted soils by laborator...
- Nanodiamond-filled chitosan as an efficient adsorb...
- Dual-emissive ratiometric fluorescent probe based ...
- Versatile graphene biosensors for enhancing human ...
- Silver nanoparticle-induced hormesis of astrogliom...
- Rediscovering Bacteria through Single-Molecule Ima...
- A comparative study on finding an effective root f...
- Nanodiamonds as “artificial proteins”: Regulation ...
- Size-dependent properties of functional PPV-based ...
- Precise temperature sensing with nanoscale thermal...
- Nanomaterials in fluorescent laser-based immunosen...
- Nanodiamond/gold nanorod nanocomposites with tunab...
- Photothermal effects during nanodiamond synthesis ...
- Effective light scattering and charge separation i...
- Emerging trends in 2D nanotechnology that are rede...
- The structural basis for filovirus neutralization ...
- Gratitude intervention modulates P3 amplitude in a...
- The Effect of Exercise on Breast Cancer–Related Ly...
- Relationship between mold exposure, specific IgE s...
- Risk Factors for Multiple Epinephrine Doses in Foo...
- Interoception is associated with heartbeat-evoked ...
- Interoceptive Accuracy Scores from the Heartbeat C...
- Altered neural inhibition responses to food cues a...
- How chronic administration of benzodiazepines lead...
- Plerixafor and related macrocyclic amines are pote...
- Giant congenital melanocytic nevus in a Cameroonia...
- Visuocortical changes during a freezing-like state...
- Detailed somatotopy in primary motor and somatosen...
- Shape responses in a macaque frontal area connecte...
- Self-monitoring in the cerebral cortex: Neural res...
- Topical Application of Photofrin® for Photodynamic...
- Effects of residual speech and auditory deprivatio...
- Exposure to positive peer sentiment about nicotine...
- Borderline personality disorder features and drink...
- Thyroid storm after choking
- Long-term thyroid disorders in pediatric survivors...
- The effect of obesity and insulin resistance on ma...
- Menu labels, for better, and worse? Exploring soci...
- Taste at first (person) sight: Visual perspective ...
- Label reading, numeracy and food & nutrition invol...
- The effect of sugar-sweetened beverage front-of-pa...
- Automated Detection of Electroencephalography Arti...
- Quantification characteristics of digital spiral a...
- Biopsia selectiva del ganglio centinela en cáncer ...
- Impaired anticipatory vision and visuomotor coordi...
- Reply
- Can natural killer cells represent an early life i...
- Cell death cascade and molecular therapy in ADAR2-...
- Mortality of patients examined at a diagnostic cen...
- Identification of differentially expressed protein...
- Effects of epidural anesthesia on postoperative na...
- Ultrasound strain imaging in assessment of false v...
- Multimodality images of myofibroblastoma in the ma...
- Evaluation of association between degree of backgr...
- Turn on ESIPT based chemosensor for histidine: App...
- Glossary
- Immunothérapie et cancer du poumon : nouveaux conc...
- Alcool et poumon : des liaisons dangereuses
- Post-curing in dental resin-based composites
- In vitro degradation of a biodegradable polylactic...
- Correlation of resin viscosity and monomer convers...
- Experimental tricalcium silicate cement induces re...
- Deciphering Drosophila female innate behaviors
- Public health air pollution impacts of pathway opt...
- Tacrolimus for the Treatment of Adults with Psoria...
- Text message intervention to reduce frequency of b...
- Pimecrolimus for the Treatment of Adults with Atop...
- Peer Support Programs for Adults Who Have Experien...
- Inactivation of Planktonic Escherichia coli by Foc...
- Effects of Non-thermal, Non-cavitational Ultrasoun...
- Turn on ESIPT based chemosensor for histidine: App...
- Glossary
- Performances of full cross-validation partial leas...
- Data on horizontally transferred genes in Californ...
- Data set on interactive service quality in higher ...
- Description of long-term monitoring of farmland bi...
- Data from proteomic analysis of bovine Longissimus...
- Data article on institutional framework and busine...
- Adsorption of organic pollutants from real refiner...
- Validation of a drooling questionnaire in Indian c...
- Expression of surfactant Protein-A in the Haemophi...
- Macrocephaly, epilepsy and intracranial cysts: an ...
- Pyrexia of unknown origin: inferior vena cava agen...
- Pregnancy and gastric cancer: diagnostic and treat...
- Delayed leucoencephalopathy after coil embolisatio...
- Pancreatic intraepithelial neoplasia in heterotopi...
-
▼
Ιουν 23
(158)
- ► Φεβρουαρίου (8116)
- ► Ιανουαρίου (7758)
-
►
2017
(111579)
- ► Δεκεμβρίου (7718)
- ► Σεπτεμβρίου (7549)
- ► Φεβρουαρίου (10753)
- ► Ιανουαρίου (10529)
-
►
2016
(16402)
- ► Δεκεμβρίου (7478)
- ► Φεβρουαρίου (900)
- ► Ιανουαρίου (1250)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου