A Case-only Genome-Wide Association Study on Gene-Sex Interaction in Allergic Rhinitis

Allergic rhinitis (AR) is a condition with a significant impact on patient's quality of life. Sex differences in the prevalence and clinical presentation of rhinitis have been reported in multiple studies. Additionally, it has comorbidities with asthma, atopic dermatitis, rhinosinusitis, otitis media, anosmia, nasal polyps and lower airway infection. As a complex phenotype, AR is affected by both genetic and environmental factors. Recent literature has focused on difference in the genomic architecture of asthma for the two sexes by considering gene-sex interaction, whereas AR has been neglected.

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