Flumatinib versus Imatinib for Newly Diagnosed Chronic Phase Chronic Myeloid Leukemia: A Phase 3, Randomized, Open-label, Multi-center FESTnd Study:
Purpose: Flumatinib has been shown to be a more potent inhibitor of BCR-ABL1 tyrosine kinase than imatinib. We evaluated the efficacy and safety of flumatinib versus imatinib, for first-line treatment of chronic phase Philadelphia chromosome-positive chronic myeloid leukemia (CML-CP). Experimental Design: In this study, 394 patients were randomized 1:1 to flumatinib 600 mg once daily (n=196) or imatinib 400 mg once daily (n=198). Results: The rate of major molecular response (MMR) at 6 months (primary end point) was significantly higher with flumatinib than with imatinib (33.7% vs 18.3%, P=0.0006), as was the rate of MMR at 12 months (52.6% vs 39.6%, P=0.0102). At 3 months, the rate of early molecular response (EMR) was significantly higher in patients receiving flumatinib than in those receiving imatinib (82.1% vs 53.3%, P<0.0001). Compared with patients receiving imatinib, more patients receiving flumatinib achieved MR4 at 6, 9 and 12 months (8.7% vs 3.6%, P=0.0358; 16.8% vs 5.1%, P=0.0002; 23.0% vs 11.7%, P=0.0034, respectively). No patients had progression to accelerated phase or blast crisis in the flumatinib arm versus 4 patients in the imatinib arm by 12 months. Adverse events of edema, pain in extremities, rash, neutropenia, anemia, and hypophosphatemia were more frequent in imatinib arm, whereas diarrhea and alanine transaminase elevation were more frequent in flumatinib arm. Conclusions:Patients receiving flumatinib achieved significantly higher rates of responses, faster and deeper responses compared with those receiving imatinib, indicating that flumatinib can be an effective first-line treatment for CML-CP. This trial was registered at www.clinicaltrials.gov as NCT02204644.
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
Αρχειοθήκη ιστολογίου
-
►
2023
(391)
- ► Φεβρουαρίου (200)
- ► Ιανουαρίου (191)
-
►
2022
(2843)
- ► Δεκεμβρίου (161)
- ► Σεπτεμβρίου (219)
- ► Φεβρουαρίου (264)
- ► Ιανουαρίου (280)
-
►
2021
(5625)
- ► Δεκεμβρίου (231)
- ► Σεπτεμβρίου (345)
- ► Φεβρουαρίου (620)
-
▼
2020
(2065)
- ► Δεκεμβρίου (535)
-
▼
Σεπτεμβρίου
(222)
-
▼
Σεπ 15
(37)
- Medicine by Alexandros G. Sfakianakis
- International Journal of Molecular Sciences
- Antibiotics
- Spiritual care experiences by cancer pati
- Focused ultrasound robotic system for v
- Macrophage HIF-1{alpha} Is an Independent Prognost...
- Radiation with STAT3 Blockade Triggers Dendritic C...
- Rhabdoid Tumors Are Sensitive to the Protein-Trans...
- Tumor Subtype Determines Therapeutic Response to C...
- Editor's Note: The Pivotal Role of Integrin {beta}...
- Clinical variability in spinal muscular atrophy ty...
- Clinical Balance Testing to Screen for Patients Wi...
- The effectiveness of radiotherapy in the treatment...
- Prophet forecasting model: a machine learning appr...
- TET1 may contribute to hypoxia-induced epithelial ...
- Correlation of Radiologic Versus Endoscopic Visual...
- Consequences of Mastoidectomy on Bone Conducted So...
- Laterality of Audiovestibular Symptoms Predicts La...
- Visualizing Affected Nerve Bundles of Cranial Nerv...
- Malformations Associated With Pediatric Congenital...
- Definitive treatment of sporadic vestibular schwan...
- Long-term survival after cemented versus uncemente...
- giant retroperitoneal neurilemmoma
- Resveratrol prevents TNF-α-induced VCAM-1 and ICAM...
- Vocal trauma especially in females and children is...
- Brazilian butt lift (BBL) surgery
- Adipose-derived stem cell enrichment is counter-pr...
- Cognitive, language and motor development of infan...
- Prolonged Survival of a Patient with Chronic Myelo...
- Correlation between the Epworth Sleepiness Scale a...
- Iron induces cell death and strengthens the effica...
- Flumatinib versus Imatinib for Newly Diagnosed Chr...
- Immediate inhibition of spinal secretory phospholi...
- Eriodictyol produces antidepressant-like effects a...
- Electroacupuncture at GV24 and bilateral GB13 impr...
- Minimal incision superficialization of the brachia...
-
▼
Σεπ 15
(37)
- ► Φεβρουαρίου (28)
-
►
2019
(9608)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3791)
- ► Ιανουαρίου (3737)
-
►
2018
(69720)
- ► Δεκεμβρίου (3507)
- ► Σεπτεμβρίου (3851)
- ► Φεβρουαρίου (8116)
- ► Ιανουαρίου (7758)
-
►
2017
(111579)
- ► Δεκεμβρίου (7718)
- ► Σεπτεμβρίου (7549)
- ► Φεβρουαρίου (10753)
- ► Ιανουαρίου (10529)
-
►
2016
(16402)
- ► Δεκεμβρίου (7478)
- ► Φεβρουαρίου (900)
- ► Ιανουαρίου (1250)
! # Ola via Alexandros G.Sfakianakis on Inoreader
Η λίστα ιστολογίων μου
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Αρχειοθήκη ιστολογίου
-
►
2023
(391)
- ► Φεβρουαρίου (200)
- ► Ιανουαρίου (191)
-
►
2022
(2843)
- ► Δεκεμβρίου (161)
- ► Σεπτεμβρίου (219)
- ► Φεβρουαρίου (264)
- ► Ιανουαρίου (280)
-
►
2021
(5625)
- ► Δεκεμβρίου (231)
- ► Σεπτεμβρίου (345)
- ► Φεβρουαρίου (620)
-
▼
2020
(2065)
- ► Δεκεμβρίου (535)
-
▼
Σεπτεμβρίου
(222)
-
▼
Σεπ 15
(37)
- Medicine by Alexandros G. Sfakianakis
- International Journal of Molecular Sciences
- Antibiotics
- Spiritual care experiences by cancer pati
- Focused ultrasound robotic system for v
- Macrophage HIF-1{alpha} Is an Independent Prognost...
- Radiation with STAT3 Blockade Triggers Dendritic C...
- Rhabdoid Tumors Are Sensitive to the Protein-Trans...
- Tumor Subtype Determines Therapeutic Response to C...
- Editor's Note: The Pivotal Role of Integrin {beta}...
- Clinical variability in spinal muscular atrophy ty...
- Clinical Balance Testing to Screen for Patients Wi...
- The effectiveness of radiotherapy in the treatment...
- Prophet forecasting model: a machine learning appr...
- TET1 may contribute to hypoxia-induced epithelial ...
- Correlation of Radiologic Versus Endoscopic Visual...
- Consequences of Mastoidectomy on Bone Conducted So...
- Laterality of Audiovestibular Symptoms Predicts La...
- Visualizing Affected Nerve Bundles of Cranial Nerv...
- Malformations Associated With Pediatric Congenital...
- Definitive treatment of sporadic vestibular schwan...
- Long-term survival after cemented versus uncemente...
- giant retroperitoneal neurilemmoma
- Resveratrol prevents TNF-α-induced VCAM-1 and ICAM...
- Vocal trauma especially in females and children is...
- Brazilian butt lift (BBL) surgery
- Adipose-derived stem cell enrichment is counter-pr...
- Cognitive, language and motor development of infan...
- Prolonged Survival of a Patient with Chronic Myelo...
- Correlation between the Epworth Sleepiness Scale a...
- Iron induces cell death and strengthens the effica...
- Flumatinib versus Imatinib for Newly Diagnosed Chr...
- Immediate inhibition of spinal secretory phospholi...
- Eriodictyol produces antidepressant-like effects a...
- Electroacupuncture at GV24 and bilateral GB13 impr...
- Minimal incision superficialization of the brachia...
-
▼
Σεπ 15
(37)
- ► Φεβρουαρίου (28)
-
►
2019
(9608)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3791)
- ► Ιανουαρίου (3737)
-
►
2018
(69720)
- ► Δεκεμβρίου (3507)
- ► Σεπτεμβρίου (3851)
- ► Φεβρουαρίου (8116)
- ► Ιανουαρίου (7758)
-
►
2017
(111579)
- ► Δεκεμβρίου (7718)
- ► Σεπτεμβρίου (7549)
- ► Φεβρουαρίου (10753)
- ► Ιανουαρίου (10529)
-
►
2016
(16402)
- ► Δεκεμβρίου (7478)
- ► Φεβρουαρίου (900)
- ► Ιανουαρίου (1250)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου