Background Prior literature has suggested synergy between immune checkpoint therapy (ICT) and radiotherapy (RT) for the treatment of brain metastases (BrM), but to the authors' knowledge the optimal timing of therapy to maximize this synergy is unclear. Methods A total of 199 patients with melanoma and non–small cell lung cancer with BrM received ICT and RT between 2007 and 2016 at the study institution. To reduce selection biases, individual metastases were included only if they were treated...
Mon Sep 14, 2020 22:03
Background Breast cancer is the most common cause of cancer mortality for all women, including American Indian and Alaska Native (AI/AN) women. The use of the 21‐gene recurrence score (RS) appears to be predictive of the benefit of chemotherapy for women with estrogen receptor (ER)–positive breast cancer. The objective of the current study was to compare RS testing between AI/AN and non‐Hispanic White (NHW) women with breast cancer. Methods The Surveillance, Epidemiology, and End Results program...
Mon Sep 14, 2020 17:44
Background State‐specific breast density notification legislation requires that women undergoing mammography be informed about breast density, with variation among states. Because mammography facilities are among the main points of contact for women undergoing mammography, research is needed to understand how facilities communicate information on breast density, cancer risk, and supplemental screening to women. Methods A cross‐sectional, 50‐item, mailed survey of 156 American College of Radiology–certified...
Mon Sep 14, 2020 17:25
Background Abiraterone and enzalutamide are high‐cost oral therapies that increasingly are used to treat patients with advanced prostate cancer; these agents carry the potential for significant financial consequences to patients. In the current study, the authors investigated coping and material measures of the financial hardship of these therapies among patients with Medicare Part D coverage. Methods The authors performed a retrospective cohort study on a 20% sample of Medicare Part D enrollees...
Mon Sep 14, 2020 17:24
Background To the authors' knowledge, AREN0321 is the first prospective clinical study of pediatric and adolescent renal cell carcinoma (RCC). Goals of the study included establishing epidemiological, treatment, and outcome data and confirming that patients with completely resected pediatric RCC, including lymph node–positive disease (N1), have a favorable prognosis without adjuvant therapy. Methods From 2006 to 2012, patients aged <30 years with centrally reviewed pathology of RCC were...
Mon Sep 14, 2020 17:24
The benefits of muscle in open lower limb fractures remains to be determined. This study compared statistically equivalent groups of open tibial fractures treated by free anterolateral thigh (ALT) flaps or ALT flaps incorporating muscle (ALT-Vastus Lateralis).Method and Results: Chang Gung Memorial Hospital, Taiwan, 2004-2008, 49 free flaps in open lower limb fractures (38 open tibial) were specifically reconstructed with free ALT or ALT-VL flaps.Risk factors for non-union: equivalent between the...
Mon Sep 14, 2020 03:00
Neoadjuvant chemoradiotherapy (nCRT) plus surgery has been shown to improve long-term outcomes in locally advanced esophageal squamous cell carcinoma (ESCC), especially those who achieve pathologic complete response (pCR) [1, 2]. However, only 33-49% obtain pCR due to tumor heterogeneity [1-3]. Therefore, the pretreatment evaluation of response significantly affects the implementation of nCRT.
Mon Sep 14, 2020 03:00
The recent update of the web-based GEC-ESTRO handbook of brachytherapy [1] has brought into attention the lack of standardized constraints based on dose volume histogram (DVH) data in head and neck brachytherapy. This is specially noteworthy in an anatomical area where treatment complications may be severe in a substantial number of cases.
Mon Sep 14, 2020 03:00
By Deborah KotzResearchers at the University of Maryland School of Medicine (UMSOM) have conducted a study that has determined the role that a critical protein plays in the development of hair cells. These hair cells are vital for hearing. Some of these cells amplify sounds that come into the ear, and others transform sound waves into electrical signals that travel to the brain. Ronna Hertzano, MD, PhD, Associate Professor in the Department of Otorhinolaryngology Head and Neck Surgery at UMSOM and Maggie...
Mon Sep 14, 2020 13:05
Across the Tree of Life (ToL), the complexity of proteomes varies widely. Our systematic analysis depicts that from the simplest archaea to mammals, the total number of proteins per proteome expanded ~200-fold. Individual proteins also became larger, and multi-domain proteins expanded ~50-fold. Apart from duplication and divergence of existing proteins, completely new proteins were born. Along the ToL, the number of different folds expanded ~5-fold and fold-combinations ~20-fold. Proteins prone to...
Mon Sep 14, 2020 03:00
There exists a subgroup of patients who undergo neck dissection (ND) who postoperatively complain of either neuropathic pain, dysaesthesia and/or discomfort that is located within the dermatomal distribution of the cervical plexus. The purpose of our study was to determine the prevalence, characteristic, and demographics of these symptoms in our patient cohort. We undertook a retrospective randomised observational cohort study of 105 patients who had undergone ND. The primary predictor variable was...
Mon Sep 14, 2020 03:00
Evaluating, Purchasing, and Incorporating High-Tech Equipment into a Facial Plastic Surgery Practice
In this article the authors discuss and analyze technological devices also known as energy-based devices and their use in skin rejuvenation, facial contouring, skin tightening, and other applications in facial plastic surgery. Energy has been applied in some form to tissue since the beginning of recorded history. The practice of applying heat to tissue with the use of cauters was used for thousands of years as an invaluable method of controlling hemorrhage. Continuous improvement of methods for using...
Mon Sep 14, 2020 03:00
Management of head and neck squamous cell carcinoma necessitates a multimodal approach. The neck dissection has evolved over many years but is well established as the key surgical intervention for management of nodal disease in the neck. The open neck dissection has many varieties based on location and degree of disease but is the gold standard surgical technique. Robot-assisted neck dissections have emerged in recent years as an alternative. More research is required to establish long-term oncologic...
Mon Sep 14, 2020 03:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08319
Mon Sep 14, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c07990
Mon Sep 14, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c06510
Mon Sep 14, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c07487
Mon Sep 14, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08109
Mon Sep 14, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08057
Mon Sep 14, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c05546
Mon Sep 14, 2020 07:00
Total joint replacement (TJR) with a prosthesis can be indicated for patients with severe temporomandibular joint (TMJ) dysfunction. Surgical accuracy is necessary for correct translation of the preoperatively predicted functional outcome, wear, and biomechanical behaviour of the patient-specific TMJ-TJR prosthesis. This study describes the first clinical applications of the patient-specific TMJ-TJR prosthesis according to the Groningen principles (G-TMJ-TJR), which was developed and validated in...
Mon Sep 14, 2020 03:00
Politics on social media may be exciting and even fun. But is it good for democracy? Jair Bolsonaro’s sweeping victory in the 2018 Brazilian elections took many people by surprise, within and outside Brazil. Yet from another angle, this success is just another chapter in a wider global story of radical right-wing populists rising to power over the past decade or so. Indeed, parallels between Bolsonaro’s political style and that of other leaders such as Donald Trump or Narendra Modi are striking,...
Mon Sep 14, 2020 22:38
Language access provisions to expand language minority voters’ access to the polls are not only about political participation. They also reveal the reproduction of white public space and white supremacy in US electoral practices. On a Monday in October 2018, about two weeks before Election Day, I returned to my desk after lunch to find Mr. Khwaja, a naturalized immigrant from Pakistan, waiting for me in my office. We had not met before and I wasn’t expecting any visitors that day, but Mumtaz, the...
Mon Sep 14, 2020 22:37
Irma McClaurin is a Black feminist anthropologist and consultant who conducts research on the social construction of inequality and its impact on African diaspora communities through an intersectional lens. She is founder of the “Irma McClaurin Black Feminist Archive” at the University of Massachusetts Amherst and was co-chair of the 2018 Seneca Falls Revisited Conference and keynote speaker for the 199th Susan B. Anthony Birthday Luncheon in 2019. Image description: A Black woman rests her chin...
Mon Sep 14, 2020 22:36
An anthropologist recalls a conversation with three older women as they reflected on their experiences of electoral politics past and present. “What politics have people of nowadays seen; it’s only eaters putting on a show,” Bokayo Jillo Tukena tells me, commenting on Kenya’s impending general election. To her, contemporary politics is merely about self-aggrandizement and the plunder of public resources. If one wanted to talk real politics, serious politics, one had to look to the past. On an unusually...
Mon Sep 14, 2020 22:35
Analytical ChemistryDOI: 10.1021/acs.analchem.0c02153
Mon Sep 14, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c02642
Mon Sep 14, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01206
Mon Sep 14, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01493
Mon Sep 14, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c02968
Mon Sep 14, 2020 07:00
Abstract Purpose To assess whether hypermetabolically-defined regions of interest (ROIs) on 3,4-dihydroxy-6-[18F]-fluoro-l-phenylalanine (FDOPA) positron emission tomography (PET) could be used to evaluate physiological features and whether there are measurable differences between molecular subtypes and tumor grades. Methods Sixty-eight treatment-naïve...
Mon Sep 14, 2020 03:00
Closely related species with parapatric elevational ranges are ubiquitous in tropical mountains worldwide. The gradient speciation hypothesis proposes that these series are the result of in situ ecological speciation driven by divergent selection across elevation. Direct tests of this scenario have been hampered by the difficulty inferring the geographic arrangement of populations at the time of divergence. In cichlids, sticklebacks, and Timema stick insects, support for ecological speciation driven...
Mon Sep 14, 2020 03:00
Publication date: Available online 13 September 2020Source: Journal of Neuroscience MethodsAuthor(s): Nirit Kara, Shlomit Flaisher-Grinberg, Haim Einat
Mon Sep 14, 2020 23:00
Abstract Purpose A previous study on computational fluid dynamics reported that a high pressure difference (PD) at the surface of a coil mass is a strong predictor of aneurysm recurrence after coil embolization. PD was calculated using a virtual post-coiling model (VM), created by manually cutting the aneurysm by the flat plane from an anatomic model created with pre-coil embolization data; however, its credibility has not been fully...
Mon Sep 14, 2020 03:00
Abstract Specific language impairment (SLI) is diagnosed when a child has difficulty in producing or understanding spoken language for no apparent reason. The study attempted to assess the sub-cortical encoding in children with SLI using speech-evoked auditory brainstem response (ABR). The objective of the study was to compare the amplitude and latency of the frequency following response (FFR) parameters between the children with SLI and typically developing children. The frequency...
Mon Sep 14, 2020 03:00
Abstract Introduction Hyperprogression, characterized by a rapid acceleration in tumor growth, is a novel pattern of progression recently described in patients treated with immune checkpoint inhibitors. This study aims to assess the incidence of hyperprogression in patients with advanced melanoma treated with checkpoint inhibitors. Methods Clinical...
Mon Sep 14, 2020 03:00
In bi-parental species, reproduction is not only a crucial life-history stage where individuals must take fitness-relevant decisions, but these decisions also need to be adjusted to the behavioural strategies of a partner. Hence, communication is required, which could be facilitated by condition-dependent signals of parental quality. Yet, these traits have (co-)evolved in multiple contexts within the family, as during reproduction different family members may coincide and interact at the site of...
Mon Sep 14, 2020 03:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN01607A, PaperWim Coucke, Mohamed Rida SoumaliTo ensure a correct interpretation of Proficiency Testing (PT) or External Quality Assessment (EQA) results, sample batches need to be homogeneous. The Importance of homogeneity testing has been underlined by...The content of this RSS Feed (c) The Royal Society of Chemistry
Mon Sep 14, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN01348J, PaperZeren Liang, Kai Gao, Mengdi Lu, Wei Peng, Shenggeng Zhu, Yixiu Huang, Long Hong, Jean-Francois MassonThe use of nanoparticle-based colorimetric methods has received considerable attention in a broad range of clinical and biomedical applications due to their high sensitivity, low cost, extreme simplicity and excellent...The content of this RSS Feed (c) The Royal Society of Chemistry
Mon Sep 14, 2020 02:00
A new study challenges more than 200 years of coral classification. Researchers say the 'traditional' method does not accurately capture the differences between species or their evolutionary relationships. They developed a new genetic tool to help better understand and ultimately work to save coral reefs.
Mon Sep 14, 2020 18:22
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Mon Sep 14, 2020 03:00
Publication date: November 2020Source: International Immunopharmacology, Volume 88Author(s): MahaYehia Kamel, Sabreen Mahmoud Ahmed, WalaaYehia Abdelzaher
Mon Sep 14, 2020 20:55
Publication date: November 2020Source: International Immunopharmacology, Volume 88Author(s): V. Kumar
Mon Sep 14, 2020 20:55
Publication date: Available online 13 September 2020Source: Critical Reviews in Oncology/HematologyAuthor(s): Caroline Himbert, Nicole Klossner, Adriana M. Coletta, Christopher A. Barnes, Joachim Wiskemann, Paul C. LaStayo, Thomas K. Varghese, Cornelia M. Ulrich
Mon Sep 14, 2020 20:54
Henoch–Schönlein purpura is a small vessel vasculitis that usually presents with palpable purpura, arthritis, abdominal pain, and nephritis. Subcutaneous oedema of dependent areas is common; however, oedema in the scalp is extremely rare especially in children older than two years. Here, we report a child with massive disfiguring scalp and facial oedema due to Henoch–Schönlein purpura. An eight-year-old boy presented with characteristic palpable purpuric rash and extensive disfiguring scalp and facial...
Mon Sep 14, 2020 15:50
Publication date: Available online 13 September 2020Source: Brain Research BulletinAuthor(s): Wen-Tzu Liao, Chia-Chih Tseng, Wan-Ting Chia, Chung-Ren Lin
Mon Sep 14, 2020 20:18
Publication date: Available online 13 September 2020Source: Brain Research BulletinAuthor(s): Sima Abbasi-Habashi, Zahra Ghasemzadeh, Ameneh Rezayof
Mon Sep 14, 2020 20:18
Abramson MJ, Gwini SM, de Klerk NH, et al. Predictive value of non-specific bronchial challenge testing for respiratory symptoms and lung function in aluminium smelter workers Occup Environ Med 2020;77:535–9.In this article, there is an error in the descriptive variables in table 1. The correct values for the last row in table 1, ‘FEV1/FVC % predicted (mean(SD))’ should be 98.3 (6.4), 99.4 (5.9), 95.7 (6.6).'
Mon Sep 14, 2020 19:03
Researchers at the City University of Hong Kong have developed a face mask containing laser-induced graphene that can kill bacteria and has demonstrated potential in deactivating coronaviruses. The graphene layer has antibacterial properties and can generate heat when exposed to sunlight, which may underlie its ability to deactivate coronaviruses. The researchers hope that such masks could help to reduce viral transmission and infection during the current COVID-19 pandemic. Face masks...
Mon Sep 14, 2020 19:44
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c06824
Mon Sep 14, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c06590
Mon Sep 14, 2020 07:00
The loss of third-order information in pre-adjusted brackets due to torsional play is a problem in clinical orthodontics. The aim of this study was to evaluate the impact of slot height, archwire height, width...
Mon Sep 14, 2020 03:00
Publication date: Available online 14 September 2020Source: Journal of ProteomicsAuthor(s): Samantha Presslee, Kirsty Penkman, Roman Fischer, Eden Richards-Slidel, John Southon, Carolina Acosta Hospitaleche, Matthew Collins, Ross MacPhee
Mon Sep 14, 2020 19:07
We present the case of an eight year old boy who presented with foreign body aspiration during the COVID-19 pandemic. The patient was taken the operating room for rigid bronchoscopy and foreign body removal. T...
Mon Sep 14, 2020 03:00
Abstract Historical cemeteries across the United States are endangered due to development, neglect, and vandalism. Cemeteries of historically oppressed groups, specifically African, African American, and Hispanic populations, are even more susceptible to destruction or damage due to systematic, institutionalized racism; neglect; segregation; and unique mortuary patterns that often result in these cemeteries being ignored, damaged, or “lost.” A specific example is provided by historical...
Mon Sep 14, 2020 03:00
We admire the authors of the article “Custom-made 3D-printed face masks in case of pandemic crisis situations with a lack of commercially available FFP2/3 masks”1 for their determination in providing rapid solutions to personal protective equipment (PPE) shortages during times of crisis. However, we feel that it is misleading to provide a face mask solution without discussion of proper fit testing (quantitative or qualitative), which importantly may put individuals trying to replicate it at increased...
Mon Sep 14, 2020 03:00
The safety concerns raised in the letter of Scott et al. are correct and have obviously to be addressed.
Mon Sep 14, 2020 03:00
Publication date: Available online 14 September 2020Source: Sleep MedicineAuthor(s): M.J. Butler, T.M. Spruill, D.A. Johnson, S. Redline, M. Sims, B.C. Jenkins, J.N. Booth, S.J. Thomas, M. Abdalla, E.C. O’Brien, R.J. Mentz, G. Ogedegbe, N.J. Williams
Mon Sep 14, 2020 18:29
Publication date: Available online 13 September 2020Source: Sleep MedicineAuthor(s): Jung-Won Shin, Jung-hun Lee, Hyeyoon Kim, Da-Hye Lee, Kwang-Hyun Baek, Jun-Sang Sunwoo, Jung-Ick Byun, Tae-Joon Kim, Jin-Sun Jun, Dohyun Han, Ki-Young Jung
Mon Sep 14, 2020 18:29
Publication date: Available online 13 September 2020Source: Radiotherapy and OncologyAuthor(s): Zijian Zhou, Jeremiah W. Sanders, Jason M. Johnson, Maria Gule-Monroe, Melissa Chen, Tina M. Briere, Yan Wang, Jong Bum Son, Mark D. Pagel, Jingfei Ma, Jing Li
Mon Sep 14, 2020 18:03
Publication date: December 2020Source: Photodiagnosis and Photodynamic Therapy, Volume 32Author(s): Can Özgür Yalçın, Burak Barut, Elif Nur Barut, Ümit Demirbaş, Tuba Dinçer, Seçkin Engin, Arzu Özel, F. Sena Sezen
Mon Sep 14, 2020 17:37
Colorimetric detection of Hg2+ with an azulene-containing chemodosimeter via dithioacetal hydrolysis
Analyst, 2020, Advance ArticleDOI: 10.1039/D0AN01404D, Paper Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Carlos M. López-Alled, Lloyd C. Murfin, Gabriele Kociok-Köhn, Tony D. James, Jannis Wenk, Simon E. LewisA simple azulene-dithiane gives a selective colorimetric response to mercury(II) in both mixed and purely aqueous solvent, which is clearly visible to the human eye.To cite this article before page numbers are assigned, use the DOI form of...
Mon Sep 14, 2020 02:00
Publication date: Available online 14 September 2020Source: American Journal of OtolaryngologyAuthor(s): Muge Kosucu, Ersagun Tuğcugil, Erhan Arslan, Şahin Ömür, Murat Livaoğlu
Mon Sep 14, 2020 17:18
Publication date: Available online 13 September 2020Source: American Journal of OtolaryngologyAuthor(s): Eri Miyata, Makoto Miyamoto, Osamu Shiromoto, Yoshiki Kobayashi, Masao Yagi, Tomoki Kitawaki, Takayuki Kawaura, Koichi Tomoda, Hiroshi Iwai
Mon Sep 14, 2020 17:18
La eterna dicotomía entre especialista y generalista puede difuminarse en los investigadores de algunas áreas de conocimiento que se centran en interacciones (aparente o relativamente) sencillas dentro de entornos complejos. Estudiar, pongamos por caso (pues es el caso de nuestro entrevistado de hoy) la dinámica parásito-hospedador, centrándose en especies muy concretas tanto de parásito como de hospedador ofrece una perspectiva privilegiada de las interacciones de este tipo dentro de las interacciones...
Mon Sep 14, 2020 16:11
Analyst, 2020, Advance ArticleDOI: 10.1039/D0AN90103B, Correction Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Adam H. Agbaria, Guy Beck, Itshak Lapidot, Daniel H. Rich, Joseph Kapelushnik, Shaul Mordechai, Ahmad Salman, Mahmoud HuleihelTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Mon Sep 14, 2020 02:00
There is an increased effort on developing novel and active surfaces in order to accelerate their osteointegration, such as nanosized crystalline hydroxyapatite coating (HAnano®). To better understand the biological behavior of osteoblasts grown on HAnano® surface, the set of data was compared with SLActive®, a hydrophilic sandblasted titanium surface. Methodologically, osteoblasts were seeded on both surfaces up to 72 hours, to allow evaluating cell adhesion, viability, and set of genes encoding...
Mon Sep 14, 2020 09:50
The antioxidant properties of uric acid may have a protective effect against the formation of oxygen radicals and subsequently against carcinogenicity. The present study aimed at evaluating the serum level of uric acid in patients with oral squamous cell carcinoma (OSCC) with different histopathological grades. In this descriptive-analytical, case-control study, patients with OSCC and healthy controls were selected and matched regarding age and gender. The serum samples were collected from patients...
Mon Sep 14, 2020 09:35
Publication date: Available online 13 September 2020Source: Pathology - Research and PracticeAuthor(s): Caixia Hu, Kai Fang, Xiufen Zhang, Zijian Guo, Lihua Li
Mon Sep 14, 2020 16:19
Publication date: Available online 13 September 2020Source: Pathology - Research and PracticeAuthor(s): Yun-Ya Luo, Zhi-Hua Wang, Qian Yu, Ling-Li Yuan, Hong-Ling Peng, Yun-Xiao Xu
Mon Sep 14, 2020 16:19
Publication date: Available online 13 September 2020Source: Pathology - Research and PracticeAuthor(s): N.A. Avdonkina, A.B. Danilova, V.A. Misyurin, E.A. Prosekina, D.V. Girdyuk, N.V. Emelyanova, T.L. Nekhaeva, G.I. Gafton, I.A. Baldueva
Mon Sep 14, 2020 16:19
Publication date: November 2020Source: Clinical Neurology and Neurosurgery, Volume 198Author(s): Tomoaki Shima, Atsushi Nagaoka, Shunsuke Yoshimura, Akari Oka, Makiko Matsumoto, Takashi Kitaoka, Akira Tsujino
Mon Sep 14, 2020 16:08
Publication date: November 2020Source: Clinical Neurology and Neurosurgery, Volume 198Author(s): Andrew Hsu, Hetal Mistry, Nupur Lala, John L. Reagan
Mon Sep 14, 2020 16:08
Publication date: October 2020Source: Acta Histochemica, Volume 122, Issue 7Author(s): Marta Hałas-Wiśniewska, Magdalena Izdebska, Wioletta Zielińska, Alina Grzanka
Mon Sep 14, 2020 15:56
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00902
Mon Sep 14, 2020 07:00
Publication date: November 2020Source: Biomedicine & Pharmacotherapy, Volume 131Author(s): Ye Yao, Han Chen, Lijing Yan, Wenbo Wang, Dongsheng Wang
Mon Sep 14, 2020 15:38
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04952
Sun Sep 13, 2020 07:00
Head and neck cancer (HNC) is a highly aggressive malignancy of the upper aerodigestive tract. Over 480,000 new cases are annually diagnosed worldwide, with an estimated mortality of at least 250,000 individuals per year [1]. Recent advances in the field of radiotherapy (RT) and concurrent chemoradiotherapy (CCRT) have significantly improved both organ preservation and locoregional control. Unfortunately, distant metastases (DM) remain a common pattern of treatment failure. This is particularly striking...
Mon Sep 14, 2020 03:00
Chordoma is a slow-growing but locally aggressive tumour arising from remnants of the notochord.[1] According to recent reports based on the surveillance, epidemiology, and end results (SEER) database in the United States, chordomas in the sacrococcygeal region comprise approximately 30% of all chordomas,[2,3] and the age-adjusted incidence rate is 0.03 per 100,000.[4] The primary definitive treatment for sacral chordoma is surgical resection; however, complete resection is often difficult due to...
Mon Sep 14, 2020 03:00
Breast cancer (BC) is the most common cancer, and the second leading cause of cancer related death among women in North America [1]. The incidence of BC rises with age, and approximately 30-40% of all the new cases occur in women aged ≥70 years [1]. The majority are diagnosed with early stage BC (EBC), and treated with breast conserving surgery (BCS). Standard adjuvant treatment approaches include breast radiotherapy (RT), endocrine therapy (ET), or both.
Mon Sep 14, 2020 03:00
Background: Surgical dehiscence can occur after lower extremity (LE) orthopedic procedures. Underlying vascular aberrancy and localized ischemia contribute to chronic wound development requiring advanced techniques such as free tissue transfer (FTT). Localized vascular pathology is an under-recognized contributing factor to such dehiscence. We reviewed our LE FTT experience in this population to analyze the incidence of arterial pathology and outcomes. Methods: Retrospective review...
Mon Sep 07, 2020 03:00
Background: Even today, severe septal deformities are a challenging problem for any rhinoplasty surgeon. Standard techniques are often not able to achieve satisfactory long-term results regarding function or aesthetic form. In such severe cases a partial or total extracorporeal septal reconstruction may be used, as these techniques provide reliable and lasting results. Methods: The aim of this work is to present our experience with the technique of total extracorporeal septal reconstruction...
Mon Sep 07, 2020 03:00
Diffuse Venous Malformations of the Upper Extremity (Bockenheimer disease): Diagnosis and Management
Purpose: Diffuse venous malformations (VMs) that involve all tissues in the upper limb and ipsilateral chest wall are known as “phlebectasia of Bockenheimer.” We describe our experience with management of this uncommon vascular anomaly. Methods: Our Vascular Anomalies Center registry comprises 18,766 patients over a 40-year period. This review identified 2,036 patients with venous malformations of the extremities (10.8%), of whom only 80 (0.43%) had Bockenheimer disease. We retrospectively...
Mon Sep 07, 2020 03:00
Introduction: Despite reports demonstrating feasibility of immediate dental implant placement (IDIP) in mandibular reconstruction with free fibula flaps (FFF) for benign disease, this practice is not routinely employed in the oncologic setting. The current study aims to demonstrate the safety of IDIP for oncologic mandible reconstruction. Methods: In 2017, our center began IDIP in FFF for oncologic patients undergoing mandibulectomy reconstruction. IDIP patients were compared to a historical...
Mon Sep 07, 2020 03:00
Introduction: For the cleft surgeon, palatal fistulae after cleft palate repair remain a difficult problem with a paucity of local tissue options to aid closure. Small clinical series have described the use of the buccal fat pad flap (BFPF) to repair palatal fistulae; however, there is no literature detailing the anatomical coverage of the flap. This study delineates the anatomy of the BFPF to guide surgeons in patient selection and examines the residual buccal fat after flap harvest to provide...
Mon Sep 07, 2020 03:00
No abstract available
Mon Sep 07, 2020 03:00
Objective: The iPhone X is the first smartphone to be released with a high-fidelity 3D scanner. At present, half of all US smartphone users use an iPhone. Recent data suggest that the majority of these 230 million individuals will upgrade to the iPhone X within two years. This represents a profound expansion in access to 3D scanning technology not only for plastic surgeons but for their patients as well. Given these implications, the purpose of this study was to compare the iPhone X scanner...
Mon Sep 07, 2020 03:00
Background: Deep dermal suturing is critical for scar quality outcomes. We evaluated a new fast medical device for dermal suturing, with hypothesis of non-inferiority with regard to clinical scar and cost-effectiveness. Methods: prospective, patient-blind, randomized, multicentre noninferiority study in 26 french hospitals. Patients were randomized 1:1 to suturing with conventional thread or a semi-automatic stapler. The Patient Scar Assessment Scale (PSAS) was rated at 3 months for...
Mon Sep 07, 2020 03:00
Interest in amputation surgery has increased in conjunction with rising public awareness about amputee care. To date, plastic surgeons have impacted the quality of life and functional potential of amputees through novel strategies for sensory feedback and prosthesis control as well as various techniques for neuroma treatment and prevention. Osseointegration, which involves the direct skeletal attachment of a prosthesis to bone, has the ability to further maximize amputee function. There exists a...
Mon Sep 07, 2020 03:00
Abstract Context and purpose Hypocalcemia and low parathyroid hormone levels have been commonly suggested as factors able to induce central nervous system disturbances. However, evidences on the occurrence of cognitive impairment are limited or underestimated. The aim of this review is, therefore, to systematically summarize the available evidence concerning the occurrence of cognitive impairment among subjects suffering from idiopathic...
Mon Sep 14, 2020 03:00
No abstract available
Mon Sep 07, 2020 03:00
No abstract available
Mon Sep 07, 2020 03:00
Publication date: Available online 13 September 2020Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): K. Mantsopoulos, M. Koch, V. Fauck, K. Schinz, M. Schapher, J. Constantinidis, W. Rösler, H. Iro
Mon Sep 14, 2020 14:58
Condition: Esophageal NeoplasmsIntervention: Sponsor: Baylor College of MedicineRecruiting
Mon Sep 14, 2020 14:44
Condition: Nasopharyngeal CarcinomaInterventions: Drug: Camrelizumab; Drug: ApatinibSponsor: Sun Yat-sen UniversityNot yet recruiting
Mon Sep 14, 2020 14:44
Efficacy and Safety of Preoperative Sintilimab Plus Nab-paclitaxel and Cisplatin in BR-ESCC Patients
Condition: Esophageal Squamous Cell CarcinomaInterventions: Drug: Sintilimab; Drug: Nab paclitaxel; Drug: CisplatinSponsors: Sun Yat-sen University; Innovent Biologics (Suzhou) Co. Ltd.; CSPC Pharmaceutical Group LimitedRecruiting
Mon Sep 14, 2020 14:44
Condition: Nasopharyngeal CarcinomaInterventions: Drug: Camrelizumab; Drug: ApatinibSponsor: Sun Yat-sen UniversityNot yet recruiting
Mon Sep 14, 2020 14:44
Conditions: Otolaryngological Disease; Artificial IntelligenceIntervention: Diagnostic Test: rigid nasal endoscopesSponsor: First Affiliated Hospital, Sun Yat-Sen UniversityRecruiting
Mon Sep 14, 2020 14:44
Publication date: Available online 13 September 2020Source: Clinical TherapeuticsAuthor(s): Aaltje Maria Stella Stoter, Marc N. Hirt, Justus Stenzig, Florian Weinberger
Mon Sep 14, 2020 14:24
Publication date: Available online 13 September 2020Source: Clinical TherapeuticsAuthor(s): Samuel J. White, James J.H. Chong
Mon Sep 14, 2020 14:24
Abstract Rationale Retrospective studies indicate that obstructive sleep apnea occurs often after aneurysmal subarachnoid hemorrhage. We aim to investigate if obstructive sleep apnea is associated with impaired blood pressure control early after subarachnoid hemorrhage. Methods Patients with subarachnoid hemorrhage were recruited and screened for sleep...
Mon Sep 14, 2020 03:00
Abstract Collaborative partnerships, which link two health organizations with shared characteristics to achieve common goals and to improve healthcare quality, are becoming increasingly common in oncology. The purpose of this study is to review the collaboration between King Hussein Cancer Center (KHCC) and Princess Margaret Cancer Centre (PM). The context, input, process, and product (CIPP) model, a quasi-experimental form of program evaluation, has been applied to the KHCC-PM...
Mon Sep 14, 2020 03:00
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