Hepatocellular carcinoma with intracranial metastasis in a Japanese macaque (Macaca fuscata).

Related Articles

Hepatocellular carcinoma with intracranial metastasis in a Japanese macaque (Macaca fuscata).

J Med Primatol. 2017 Apr 03;:

Authors: Miyabe-Nishiwaki T, Hirata A, Kaneko A, Ishigami A, Miyamoto Y, Yamanaka A, Owaki K, Sakai H, Yanai T, Suzuki J

Abstract
BACKGROUND: A 23-year-old male Japanese macaque (Macaca fuscata) showed left ptosis, which progressed to exophthalmos.
METHODS: The macaque underwent a clinical examination, CT and MRI, and was euthanized. Necropsy and histopathological examination were performed after euthanasia.
RESULTS: The CT revealed and MRI confirmed an intracranial mass at the skull base with orbital extension. At necropsy, there were a large hepatic mass and an intracranial mass compressing the left temporal lobe of the brain. Histopathological and immunohistological examinations revealed that the masses were hepatocellular carcinoma (HCC) and a metastatic lesion. In both the primary and metastatic lesions, neoplastic hepatocytes were arranged mainly in a trabecular pattern. Immunohistochemically, the tumor cells were positive for cytokeratin (AE1/AE3 and CAM5.2) and hepatocyte paraffin 1 and negative for cytokeratin 7 and 20 and vimentin.
CONCLUSION: To our knowledge, this is the first case report of HCC with intracranial metastasis in a macaque.

PMID: 28369930 [PubMed - as supplied by publisher]

http://ift.tt/2oE4YnA