A number of molecularly targeted anticancer drugs that efficiently inhibit receptor tyrosine kinases, socalled receptor tyrosine kinase inhibitors (TKIs), have been developed. Although these receptor TKIs are generally well tolerated, unexpected toxicities sometimes occur in various organs. TKI-induced adverse events not only lower the quality of life of cancer patients but also reduce dose intensity, and sometimes result in treatment discontinuation. To reduce adverse drug events and increase treatment efficacy, oncologists and clinical pharmacologists have made efforts to establish strategies to treat patients via optimal selection and dosing of TKIs. Drug efficacy and safety are generally determined by the interplay of multiple processes that regulate pharmacokinetics and pharmacodynamics (toxicodynamics). In this review article, we first provide an overview of adverse events caused by receptor TKIs, focusing on gefitinib, erlotinib, sorafenib and sunitinib, followed by a discussion on the association between pharmacokinetics and toxicities induced by these TKIs, with a focus on establishing optimal personalized treatment strategies by controlling pharmacokinetic properties. Finally, we introduce new findings on the molecular mechanisms of TKIinduced toxicities, elucidated using a new strategy, systems toxicology.
http://ift.tt/2nS4Fpr
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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! # Ola via Alexandros G.Sfakianakis on Inoreader
Η λίστα ιστολογίων μου
Τρίτη 4 Απριλίου 2017
Toxicities of Receptor Tyrosine Kinase Inhibitors in Cancer Pharmacoth erapy: Management with Clinical Pharmacology
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- Development of the GREEN (Garden Resources, Educat...
- Simplifying the Forehead Flap for Nasal Reconstruc...
- Components of the Hanging Columella: Strategies fo...
- A National Study of the Impact of Delayed Flap Tim...
- Comments on "Seroma in Prosthetic Breast Reconstru...
- Reply to Comments on "Seroma in Prosthetic Breast ...
- New cranium of the endemic Caribbean platyrrhine, ...
- Seeds in the liver
- Elongated Dorsal Nasal Flap to Reconstruct Large D...
- Large Elliptical Specimens and the Single Section ...
- Corrective Hyaluronic Acid Fillers and Combination...
- Striae Distensae: Preventative and Therapeutic Mod...
- IncobotulinumtoxinA for Aesthetic Indications: A S...
- Creation and Validation of a Photonumeric Scale to...
- Autologous Pure Platelet-Rich Plasma Dermal Inject...
- Advancing Keloid Treatment: A Novel Multimodal App...
- Platelet-Rich Plasma for the Treatment of Female P...
- A 56-Year-Old Woman With Multiple Subcutaneous Pai...
- A 56-Year-Old Woman With Multiple Subcutaneous Pai...
- Primary Cutaneous Follicular Helper T-Cell Lymphom...
- A 32-Year-Old Woman With Tender Nodules That Ulcer...
- Winkelmann Granuloma.
- Erythematous Bullous Patch in a Patient With Myelo...
- Commentary on Some Recent Theses Relevant to Comba...
- Multiple cutaneous reticulohistiocytosis with T-ce...
- Unusual clinical umbilical hernia: pitfall
- Multiple cutaneous reticulohistiocytosis with T-ce...
- Biologics,Biologic Response Modifiers,Biopharmaceu...
- Biologic Therapies of Immunologic Diseases.
- Biopharmaceuticals in Allergic Disease: Finding th...
- Erratum.
- Future Prospects of Biologic Therapies for Immunol...
- Pharmacoeconomics of Biologic Therapy.
- Adverse Reactions to Biologic Therapy.
- Biologic Therapies for Immunoglobulin E-mediated F...
- Monoclonal Antibodies for the Treatment of Nasal P...
- Biologic Therapy in Chronic Obstructive Pulmonary ...
- Biologic and New Therapies in Asthma.
- Biologic Therapy in the Treatment of Chronic Skin ...
- Immune Mechanisms and Novel Targets in Rheumatoid ...
- Biologic Therapies for Autoimmune and Connective T...
- Patient Characteristics and Individualization of B...
- Biological Therapies of Immunologic Diseases: Stra...
- Inflammatory Disorders Associated with Allergy: Ov...
- Contractile force generation by 3D hiPSC-derived c...
- Microfluidic-enhanced 3D bioprinting of aligned my...
- Raman spectroscopy for the detection of organ dist...
- Can We Improve the Laser Etching with the Digitall...
- Minimally Invasive Excision of Epulides with a CO2...
- Future Meetings
- Magnetic and thermal transport properties of SrFe1...
- Functionally graded shape memory alloys: Design, f...
- Future Meetings
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- Complete Metabolic Response on Interim 18F-Fluorod...
- Silk I and Silk II Studied by Fast Scanning Calori...
- Cancer chemopreventive activity of compounds isola...
- IFC (Journal of Ethnopharmacology)
- Predictors of hearing recovery in patients with se...
- The T4/T3 quotient as a risk factor for differenti...
- Systemic therapy in the curative treatment of head...
- Predictors of hearing recovery in patients with se...
- The T4/T3 quotient as a risk factor for differenti...
- Systemic therapy in the curative treatment of head...
- Recovery of Abnormal ABR in Neonates and Infants a...
- Recovery of Abnormal ABR in Neonates and Infants a...
- Prolactin receptors in Rip-cre cells, but not in A...
- "J BUON"[jour]; +44 new citations
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- Topical Drug Therapies for Chronic Rhinosinusitis
- Evolution in Visualization for Sinus and Skull Bas...
- Effect of androgen on Kiss1 expression and luteini...
- Topical Drug Therapies for Chronic Rhinosinusitis
- Evolution in Visualization for Sinus and Skull Bas...
- A Tunable Diffusion-Consumption Mechanism of Cytok...
- Iodide Handling Disorders (NIS, TPO, TG, IYD)
- Features of sinonasal hemangioma: A retrospective ...
- A case of extensive pharyngeal vascular malformati...
- Features of sinonasal hemangioma: A retrospective ...
- A case of extensive pharyngeal vascular malformati...
- Reading Comprehension Deficits in Adolescents: Add...
- IL-5-stimulated eosinophils adherent to periostin ...
- IL-5-stimulated eosinophils adherent to periostin ...
- A randomized controlled phase II clinical trial co...
- RNase 7 downregulates TH2 cytokine production by a...
- A randomized controlled phase II clinical trial co...
- RNase 7 downregulates TH2 cytokine production by a...
- Attention Mediates the Flexible Allocation of Visu...
- Conceptual Biases Explain Distortion Differences B...
- The Motor-Cognitive Model of Motor Imagery: Eviden...
- The Magical Number One-on-Square-Root-Two: The Dou...
- Avoiding the Conflict: Metacognitive Awareness Dri...
- The Role of Allograph Representations in Font-Inva...
- Domain-General Biases in Spatial Localization: Evi...
- Co-Representation of Others' Task Constraints in J...
- Dual-Target Cost in Visual Search for Multiple Unf...
- Cognitive-Behavioral High Parental Involvement Tre...
- Clinical laser treatment of toenail onychomycoses
- Training spatial-simultaneous working memory in in...
- Dictating genomic destiny: Epigenetic regulation o...
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