Publication date: 5 November 2017
Source:Molecular and Cellular Endocrinology, Volume 455
Author(s): Nicole E. Cummings, Dudley W. Lamming
All organisms need to be capable of adapting to changes in the availability and composition of nutrients. Over 75 years ago, researchers discovered that a calorie restricted (CR) diet could significantly extend the lifespan of rats, and since then a CR diet has been shown to increase lifespan and healthspan in model organisms ranging from yeast to non-human primates. In this review, we discuss the effects of a CR diet on metabolism and healthspan, and highlight emerging evidence that suggests that dietary composition – the precise macronutrients that compose the diet – may be just as important as caloric content. In particular, we discuss recent evidence that suggests protein quality may influence metabolic health. Finally, we discuss key metabolic pathways which may influence the response to CR diets and altered macronutrient composition. Understanding the molecular mechanisms responsible for the effects of CR and dietary composition on health and longevity may allow the design of novel therapeutic approaches to age-related diseases.
http://ift.tt/2eNAJKK
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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- Subacute Fluoxetine Reduces Signs of Hippocampal D...
- Ultra-micronized Palmitoylethanolamide: An Efficac...
- Demonstration of Biological and Immunological Equi...
- The Effect of Pyrroloquinoline Quinone on Apoptosi...
- Dendrites, 3rd Edition
- SAPHO syndrome associated with hidradenitis suppur...
- Teriflunomide-induced psoriasiform changes of fing...
- Evaluation of the relation between lipid coat, tra...
- Large-Scale Quantitative Proteomics Identifies the...
- Alternative Progenitor Cells Compensate to Rebuild...
- FPGA implementation of real-time SENSE reconstruct...
- Static and dynamic liver stiffness: An ex vivo por...
- MRI protocol optimization for quantitative DCE-MRI...
- The development and optimisation of 3D black-blood...
- COnstrained Data Extrapolation (CODE): A new appro...
- Reduced distortion artifact whole brain CBF mappin...
- Neonatal skin care: what should we do? A four-week...
- A photoconverter gel-assisted blue light therapy f...
- Triple cancers concurrently detected in a case of ...
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- Toxicity, uptake, and accumulation of nano and bul...
- EGFR T790M mutation testing of non-small cell lung...
- Histiocytoid cardiomyopathy and ventricular noncom...
- Upregulation of uc.189 in patients with esophageal...
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- Assessing Readability and Reliability of Online Pa...
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- The relationship between the GJB3 c.538C>T variant...
- Introducing nerve-sparing approach during minimall...
- Perioperative Therapies – Enhancing the Impact of ...
- Frequency and Prognostic Significance of Incidenta...
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