Publication date: November 2017
Source:Journal of Dairy Science, Volume 100, Issue 11
Author(s): Christos Dadousis, Sara Pegolo, Guilherme J.M. Rosa, Giovanni Bittante, Alessio Cecchinato
The aim of this study was to perform genome-wide associations (GWAS) and gene-set enrichment analyses with protein composition and cheesemaking-related latent variables (factors; F) in a cohort of 1,011 Italian Brown Swiss cows. Factor analysis was applied to identify latent structures of 26 phenotypes related to bovine milk quantity and quality, protein fractions [αS1-, αS2-, β-, and κ-casein (CN), β-lactoglobulin, and α-lactalbumin (α-LA)], coagulation and curd firming at time t (CFt) measures, and cheese properties [cheese yield (%CY) and nutrients recovery in the curd] of individual cows. Ten orthogonal F were extracted, explaining 74% of the original variability. Factor 1%CY underlined the %CY characteristics, F2CFt was related to the CFt process parameters, F3Yield was considered as descriptor of milk and solids yield, whereas F4Cheese N underscored the presence of nitrogenous compounds (N) into the cheese. Four more F were related to the milk caseins (F5αS1-β-CN, F7β-κ-CN, F8αS2-CN, and F9αS1-CN-Ph) and 1 F was linked to the whey protein (F10α-LA); 1 F underlined the udder health status (F6Udder health). All cows were genotyped with the Illumina BovineSNP50 Bead Chip v.2 (Illumina Inc., San Diego, CA). Single marker regression GWAS were fitted. Gene-set enrichment analysis was run on GWAS results, using the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway databases, to reveal ontologies or pathways associated with the F. All F but F3Yield showed significance in GWAS. Signals in 10 Bos taurus autosomes (BTA) were detected. High peaks on BTA6 (∼87 Mbp) were found for F6β-κ-CN, F5αS1-β-CN, and at the tail of BTA11 (∼104 Mbp) for F4Cheese N. Gene-set enrichment analyses showed significant results (false discovery rate at 5%) for F8αS2-CN, F1%CY, F4Cheese N, and F10α-LA. For F8αS2-CN, 33 Gene Ontology terms and 3 Kyoto Encyclopedia of Genes and Genomes categories were enriched, including terms related to ion transport and homeostasis, neuron function or part, and GnRH signaling pathway. Our results support the feasibility of factor analysis as a dimension reduction technique in genomic studies and evidenced a potential key role of αS2-CN in milk quality and composition.
http://ift.tt/2yGqkJa
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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! # Ola via Alexandros G.Sfakianakis on Inoreader
Η λίστα ιστολογίων μου
Τετάρτη 11 Οκτωβρίου 2017
Genome-wide association and pathway-based analysis using latent variables related to milk protein composition and cheesemaking traits in dairy cattle
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- Microphthalmia with linear skin defects (MLS) synd...
- Linear IgA bullous dermatosis associated with amyo...
- Milia: a useful clinical marker of CYLD mutation c...
- Microphthalmia with linear skin defects (MLS) synd...
- Linear IgA bullous dermatosis associated with amyo...
- Milia: a useful clinical marker of CYLD mutation c...
- Scorpion bite-induced ischaemic stroke
- Oesophageal ischaemia: an uncommon cause of chest ...
- Posterior fossa progressive multifocal leukoenceph...
- Subclinical meningoventriculitis as a cause of obs...
- A unique case of nephrogenic systemic fibrosis fro...
- Allergic bronchopulmonary mycosis presenting as a ...
- Unusual case of prosthetic joint infection caused ...
- Cryptococcus neoformans osteomyelitis and intramus...
- Olfactory bulb agenesis with normal sexual hormones
- Hydatid cyst of the thigh: a challenging diagnosis
- Syncope from radiation-induced baroreceptor failure
- Live 'Baby dance among the red blood cells
- Erdheim-Chester disease: atypical presentation of ...
- Radioactive and stable cesium isotope distribution...
- Cancer Immunotherapy Trials Underutilize Immune Re...
- A Comprehensive Review of Sequencing and Combinati...
- Cost‐Effectiveness of Nivolumab in Recurrent Metas...
- Outcomes of a Specialized Interdisciplinary Approa...
- Prof. Gian Franco Bottazzo MD FRCP FRCPath (1946–2...
- Luciano Martini (1927–2017): a memoir
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- Synchronous HPV-Related Cancer of Bilateral Tonsil...
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- Venous Thromboembolism After Adult Lung Transplant...
- The Optimization of the Prevascularization Procedu...
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- In search of a comprehensible set of endpoints for...
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- Prognostic significance of standardized uptake val...
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- Continuous positive airway pressure treatment with...
- The effect of sleep duration and sleep quality on ...
- Assessment of intervention-related changes in non-...
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- Longitudinal associations between sleep and anxiet...
- Analysis and experimental evaluation of shunt acti...
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- Audiological findings in a de novo mutation of ANK...
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- Complications and Patient-Reported Outcomes after ...
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- Parental perceptions of childhood seasonal influen...
- Evaluation of T and B memory cell responses elicit...
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- Cost-effectiveness of a potential group B streptoc...
- Adjuvanting an inactivated influenza vaccine with ...
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- Spectrum of orocutaneous disease associations
- Editorial Board
- CME examination
- Atypical features and systemic associations in ext...
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- Assessment of dermatology clinic resources at safe...
- CME examination
- Intrathyroidal carotid artery and nonrecurring rig...
- Chimeric thoracoacromial artery perforator flap fo...
- Pathologic significance of a novel oncoprotein in ...
- Intrathyroidal carotid artery and nonrecurring rig...
- Familial clustering of oropharyngeal squamous cell...
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