Publication date: November 2017
Source:Journal of Dairy Science, Volume 100, Issue 11
Author(s): T. Xu, F.C. Cardoso, A. Pineda, E. Trevisi, X. Shen, F. Rosa, J.S. Osorio, J.J. Loor
Long-term feeding of high-grain diets to dairy cows often results in systemic inflammation characterized by alterations in acute-phase proteins and other biomarkers, both in plasma and immune-responsive tissues like the liver. The molecular and systemic changes that characterize an acute grain feeding challenge remain unclear. The current study involved 6 Holstein and 6 Jersey cows in a replicated 2 × 2 Latin square. Periods (10 d) were divided into 4 stages (S): S1, d 1 to 3, served as baseline with total mixed ration (TMR) ad libitum; S2, d 4, served as restricted feeding, with cows offered 50% of the average daily intake observed in S1; S3, d 5, a grain challenge was performed, in which cows were fed a TMR ad libitum without (CON) or with an additional pellet wheat-barley (1:1; HIG) at 20% of dry matter intake top-dressed onto the TMR; S4, d 6 to 10, served as recovery during which cows were allowed ad libitum access to the TMR. Among the 28 biomarkers analyzed in blood 12 h after grain challenge on d 5, the concentrations of fatty acids and bilirubin increased in HIG Holstein but not Jersey cows. In Holsteins, feeding HIG also increased total protein and albumin while decreasing ceruloplasmin, myeloperoxidase, and alkaline phosphatase concentrations. At the molecular level, hepatic genes associated with inflammation (IL1B, IL6, TNF, TLR4, MYD88, and NFKB1) were upregulated in Holstein cows fed HIG versus CON. Despite such response, expression of the acute-phase proteins SAA and HP in Holsteins fed HIG compared with CON was markedly downregulated. In Holsteins fed HIG versus CON, the marked downregulation of SCD, ELOVL6, and MTTP along with upregulated CPT1A, ACOX1, and APOA5 indicated alterations in fatty acid and lipoprotein metabolism during grain challenge. Genes related to ketogenesis (HMGCS2 and ACAT1) were upregulated in Jerseys, and gluconeogenic genes (PDK4 and PCK1) were upregulated in Holstein cows fed HIG, suggesting alterations in ketone body and glucose production. Expression of phosphorylated p70S6K1, RPS6, and 4EBP1 proteins, as well as total mechanistic target of rapamycin (mTOR) protein, decreased in Holsteins fed HIG, whereas phosphorylated mTOR and 4EBP1 proteins increased in Jerseys fed HIG. From a metabolic and inflammatory biomarker standpoint, data indicate that Jersey cows better tolerated the acute grain challenge. Alterations in mTOR signaling proteins in both Jerseys and Holsteins fed HIG suggest a potential role for exogenous AA in the hepatic adaptations to grain challenge. It remains to be determined if these acute responses to a grain challenge can elicit long-term liver dysfunction, which could negatively affect welfare of the cow.
http://ift.tt/2ygsUEC
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
Αρχειοθήκη ιστολογίου
-
►
2023
(391)
- ► Φεβρουαρίου (200)
- ► Ιανουαρίου (191)
-
►
2022
(2843)
- ► Δεκεμβρίου (161)
- ► Σεπτεμβρίου (219)
- ► Φεβρουαρίου (264)
- ► Ιανουαρίου (280)
-
►
2021
(5625)
- ► Δεκεμβρίου (231)
- ► Σεπτεμβρίου (345)
- ► Φεβρουαρίου (620)
-
►
2020
(2065)
- ► Δεκεμβρίου (535)
- ► Σεπτεμβρίου (222)
- ► Φεβρουαρίου (28)
-
►
2019
(9608)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3791)
- ► Ιανουαρίου (3737)
-
►
2018
(69720)
- ► Δεκεμβρίου (3507)
- ► Σεπτεμβρίου (3851)
- ► Φεβρουαρίου (8116)
- ► Ιανουαρίου (7758)
-
▼
2017
(111579)
- ► Δεκεμβρίου (7718)
-
▼
Οκτωβρίου
(6996)
-
▼
Οκτ 11
(176)
- Microphthalmia with linear skin defects (MLS) synd...
- Linear IgA bullous dermatosis associated with amyo...
- Milia: a useful clinical marker of CYLD mutation c...
- Microphthalmia with linear skin defects (MLS) synd...
- Linear IgA bullous dermatosis associated with amyo...
- Milia: a useful clinical marker of CYLD mutation c...
- Scorpion bite-induced ischaemic stroke
- Oesophageal ischaemia: an uncommon cause of chest ...
- Posterior fossa progressive multifocal leukoenceph...
- Subclinical meningoventriculitis as a cause of obs...
- A unique case of nephrogenic systemic fibrosis fro...
- Allergic bronchopulmonary mycosis presenting as a ...
- Unusual case of prosthetic joint infection caused ...
- Cryptococcus neoformans osteomyelitis and intramus...
- Olfactory bulb agenesis with normal sexual hormones
- Hydatid cyst of the thigh: a challenging diagnosis
- Syncope from radiation-induced baroreceptor failure
- Live 'Baby dance among the red blood cells
- Erdheim-Chester disease: atypical presentation of ...
- Radioactive and stable cesium isotope distribution...
- Cancer Immunotherapy Trials Underutilize Immune Re...
- A Comprehensive Review of Sequencing and Combinati...
- Cost‐Effectiveness of Nivolumab in Recurrent Metas...
- Outcomes of a Specialized Interdisciplinary Approa...
- Prof. Gian Franco Bottazzo MD FRCP FRCPath (1946–2...
- Luciano Martini (1927–2017): a memoir
- Peritoneal pre-conditioning reduces macrophage mar...
- Synchronous HPV-Related Cancer of Bilateral Tonsil...
- Synchronous HPV-Related Cancer of Bilateral Tonsil...
- Management of Patients who Receive an Organ Transp...
- Rhesus Alloimunization Occurs After Rh Incompatibl...
- Venous Thromboembolism After Adult Lung Transplant...
- The Optimization of the Prevascularization Procedu...
- Interactive effects of PAHs with different rings a...
- In search of a comprehensible set of endpoints for...
- Prognostic significance of standardized uptake val...
- Prognostic significance of standardized uptake val...
- Fluoride containing bioactive glass composite for ...
- Structural and Ultrastructural Analyses of Bone Re...
- Effect of an alkaline environment on the engineeri...
- Continuous positive airway pressure treatment with...
- The effect of sleep duration and sleep quality on ...
- Assessment of intervention-related changes in non-...
- Prevalence of sleep-disordered breathing in Japane...
- Longitudinal associations between sleep and anxiet...
- Analysis and experimental evaluation of shunt acti...
- Long-term treatment with dopamine D3 receptor agon...
- Gender differences in sleep symptoms after repeat ...
- Photoreduction of Cr(VI) in water using BiVO 4 -Fe...
- The role of α1- and α2-adrenoceptor subtypes in th...
- Audiological findings in a de novo mutation of ANK...
- The addition of PRP to facial lipofilling: a doubl...
- The lateral thigh perforator (LTP) flap for autolo...
- Complications and Patient-Reported Outcomes after ...
- Outcomes After Phalloplasty: Do Transgender Patien...
- From Classical to Unusual: Report on 5 Cases of Tr...
- Tumour auto-contouring on 2d cine MRI for locally ...
- Interim 18F-FDG-PET/CT during chemo-radiotherapy i...
- Split-Overlapping Genioplasty: Surgical Technique,...
- A Research of Pyogenic Granuloma Genesis Factor Wi...
- Lolium perenne peptides for treatment of grass pol...
- Genome-wide association study and meta-analysis in...
- A systematic review of factors affecting vaccine u...
- Salmonella Enteritidis with double deletion in pho...
- Personality and demographic correlates of New Zeal...
- Parental perceptions of childhood seasonal influen...
- Evaluation of T and B memory cell responses elicit...
- Association of both consistency and strength of se...
- Investigating the candidacy of a capsular polysacc...
- Cost-effectiveness of a potential group B streptoc...
- Adjuvanting an inactivated influenza vaccine with ...
- Value of an in-depth analysis of unpublished data ...
- Trends in pneumococcal meningitis hospitalizations...
- CHRONOVAC VOYAGEUR: A study of the immune response...
- Nano-material as an excellent catalyst for reducin...
- Food stories: Unraveling the mechanisms underlying...
- EZH2 regulates dental pulp inflammation by direct ...
- A dual energy micro-CT methodology for visualizati...
- Different levels of visual perceptual skills are a...
- Cancer Drugs Dominate New FDA Watch List
- FTIR and GC-MS spectral datasets of wax from Pinus...
- Microarray analysis of subcutaneous adipose tissue...
- Survival Disparity Following Abdominal Aortic Aneu...
- Prevalence of pediatric alopecia areata among 572,...
- A meta-analysis of nevus-associated melanoma: Prev...
- Spectrum of orocutaneous disease associations
- Editorial Board
- CME examination
- Atypical features and systemic associations in ext...
- High prevalence of combination tanning among under...
- Spectrum of orocutaneous disease associations
- Assessment of dermatology clinic resources at safe...
- CME examination
- Intrathyroidal carotid artery and nonrecurring rig...
- Chimeric thoracoacromial artery perforator flap fo...
- Pathologic significance of a novel oncoprotein in ...
- Intrathyroidal carotid artery and nonrecurring rig...
- Familial clustering of oropharyngeal squamous cell...
- Diagnostik und operative Therapie des muskelinvasi...
- Light-emitting diode 585nm photomodulation inhibit...
-
▼
Οκτ 11
(176)
- ► Σεπτεμβρίου (7549)
- ► Φεβρουαρίου (10753)
- ► Ιανουαρίου (10529)
-
►
2016
(16402)
- ► Δεκεμβρίου (7478)
- ► Φεβρουαρίου (900)
- ► Ιανουαρίου (1250)
! # Ola via Alexandros G.Sfakianakis on Inoreader
Η λίστα ιστολογίων μου
Τετάρτη 11 Οκτωβρίου 2017
Grain challenge affects systemic and hepatic molecular biomarkers of inflammation, stress, and metabolic responses to a greater extent in Holstein than Jersey cows
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Αρχειοθήκη ιστολογίου
-
►
2023
(391)
- ► Φεβρουαρίου (200)
- ► Ιανουαρίου (191)
-
►
2022
(2843)
- ► Δεκεμβρίου (161)
- ► Σεπτεμβρίου (219)
- ► Φεβρουαρίου (264)
- ► Ιανουαρίου (280)
-
►
2021
(5625)
- ► Δεκεμβρίου (231)
- ► Σεπτεμβρίου (345)
- ► Φεβρουαρίου (620)
-
►
2020
(2065)
- ► Δεκεμβρίου (535)
- ► Σεπτεμβρίου (222)
- ► Φεβρουαρίου (28)
-
►
2019
(9608)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (3791)
- ► Ιανουαρίου (3737)
-
►
2018
(69720)
- ► Δεκεμβρίου (3507)
- ► Σεπτεμβρίου (3851)
- ► Φεβρουαρίου (8116)
- ► Ιανουαρίου (7758)
-
▼
2017
(111579)
- ► Δεκεμβρίου (7718)
-
▼
Οκτωβρίου
(6996)
-
▼
Οκτ 11
(176)
- Microphthalmia with linear skin defects (MLS) synd...
- Linear IgA bullous dermatosis associated with amyo...
- Milia: a useful clinical marker of CYLD mutation c...
- Microphthalmia with linear skin defects (MLS) synd...
- Linear IgA bullous dermatosis associated with amyo...
- Milia: a useful clinical marker of CYLD mutation c...
- Scorpion bite-induced ischaemic stroke
- Oesophageal ischaemia: an uncommon cause of chest ...
- Posterior fossa progressive multifocal leukoenceph...
- Subclinical meningoventriculitis as a cause of obs...
- A unique case of nephrogenic systemic fibrosis fro...
- Allergic bronchopulmonary mycosis presenting as a ...
- Unusual case of prosthetic joint infection caused ...
- Cryptococcus neoformans osteomyelitis and intramus...
- Olfactory bulb agenesis with normal sexual hormones
- Hydatid cyst of the thigh: a challenging diagnosis
- Syncope from radiation-induced baroreceptor failure
- Live 'Baby dance among the red blood cells
- Erdheim-Chester disease: atypical presentation of ...
- Radioactive and stable cesium isotope distribution...
- Cancer Immunotherapy Trials Underutilize Immune Re...
- A Comprehensive Review of Sequencing and Combinati...
- Cost‐Effectiveness of Nivolumab in Recurrent Metas...
- Outcomes of a Specialized Interdisciplinary Approa...
- Prof. Gian Franco Bottazzo MD FRCP FRCPath (1946–2...
- Luciano Martini (1927–2017): a memoir
- Peritoneal pre-conditioning reduces macrophage mar...
- Synchronous HPV-Related Cancer of Bilateral Tonsil...
- Synchronous HPV-Related Cancer of Bilateral Tonsil...
- Management of Patients who Receive an Organ Transp...
- Rhesus Alloimunization Occurs After Rh Incompatibl...
- Venous Thromboembolism After Adult Lung Transplant...
- The Optimization of the Prevascularization Procedu...
- Interactive effects of PAHs with different rings a...
- In search of a comprehensible set of endpoints for...
- Prognostic significance of standardized uptake val...
- Prognostic significance of standardized uptake val...
- Fluoride containing bioactive glass composite for ...
- Structural and Ultrastructural Analyses of Bone Re...
- Effect of an alkaline environment on the engineeri...
- Continuous positive airway pressure treatment with...
- The effect of sleep duration and sleep quality on ...
- Assessment of intervention-related changes in non-...
- Prevalence of sleep-disordered breathing in Japane...
- Longitudinal associations between sleep and anxiet...
- Analysis and experimental evaluation of shunt acti...
- Long-term treatment with dopamine D3 receptor agon...
- Gender differences in sleep symptoms after repeat ...
- Photoreduction of Cr(VI) in water using BiVO 4 -Fe...
- The role of α1- and α2-adrenoceptor subtypes in th...
- Audiological findings in a de novo mutation of ANK...
- The addition of PRP to facial lipofilling: a doubl...
- The lateral thigh perforator (LTP) flap for autolo...
- Complications and Patient-Reported Outcomes after ...
- Outcomes After Phalloplasty: Do Transgender Patien...
- From Classical to Unusual: Report on 5 Cases of Tr...
- Tumour auto-contouring on 2d cine MRI for locally ...
- Interim 18F-FDG-PET/CT during chemo-radiotherapy i...
- Split-Overlapping Genioplasty: Surgical Technique,...
- A Research of Pyogenic Granuloma Genesis Factor Wi...
- Lolium perenne peptides for treatment of grass pol...
- Genome-wide association study and meta-analysis in...
- A systematic review of factors affecting vaccine u...
- Salmonella Enteritidis with double deletion in pho...
- Personality and demographic correlates of New Zeal...
- Parental perceptions of childhood seasonal influen...
- Evaluation of T and B memory cell responses elicit...
- Association of both consistency and strength of se...
- Investigating the candidacy of a capsular polysacc...
- Cost-effectiveness of a potential group B streptoc...
- Adjuvanting an inactivated influenza vaccine with ...
- Value of an in-depth analysis of unpublished data ...
- Trends in pneumococcal meningitis hospitalizations...
- CHRONOVAC VOYAGEUR: A study of the immune response...
- Nano-material as an excellent catalyst for reducin...
- Food stories: Unraveling the mechanisms underlying...
- EZH2 regulates dental pulp inflammation by direct ...
- A dual energy micro-CT methodology for visualizati...
- Different levels of visual perceptual skills are a...
- Cancer Drugs Dominate New FDA Watch List
- FTIR and GC-MS spectral datasets of wax from Pinus...
- Microarray analysis of subcutaneous adipose tissue...
- Survival Disparity Following Abdominal Aortic Aneu...
- Prevalence of pediatric alopecia areata among 572,...
- A meta-analysis of nevus-associated melanoma: Prev...
- Spectrum of orocutaneous disease associations
- Editorial Board
- CME examination
- Atypical features and systemic associations in ext...
- High prevalence of combination tanning among under...
- Spectrum of orocutaneous disease associations
- Assessment of dermatology clinic resources at safe...
- CME examination
- Intrathyroidal carotid artery and nonrecurring rig...
- Chimeric thoracoacromial artery perforator flap fo...
- Pathologic significance of a novel oncoprotein in ...
- Intrathyroidal carotid artery and nonrecurring rig...
- Familial clustering of oropharyngeal squamous cell...
- Diagnostik und operative Therapie des muskelinvasi...
- Light-emitting diode 585nm photomodulation inhibit...
-
▼
Οκτ 11
(176)
- ► Σεπτεμβρίου (7549)
- ► Φεβρουαρίου (10753)
- ► Ιανουαρίου (10529)
-
►
2016
(16402)
- ► Δεκεμβρίου (7478)
- ► Φεβρουαρίου (900)
- ► Ιανουαρίου (1250)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου