Occupational mycosis fungoides - a case series.

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Occupational mycosis fungoides - a case series.

Int J Dermatol. 2017 Jul;56(7):733-737

Authors: Slodownik D, Moshe S, Sprecher E, Goldberg I

Abstract
BACKGROUND: Mycosis fungoides (MF) is the most frequent type of cutaneous T-cell lymphoma. MF has long been considered to develop as the result of a combination of genetic defects and exogenous triggers. Although no specific MF-associated environmental trigger has been established to date, some studies have suggested that occupational exposures may occasionally trigger the onset of MF.
OBJECTIVE: In this observational study, we aimed at underscoring the potential association between occupational exposure and MF.
METHODS: We ascertained a cohort of 150 MF patients for possible occupational exposure.
RESULTS: Five MF patients with occupational exposure were identified in our cohort. Three patients had intensive contact with aromatic hydrocarbons; two of them were working in the same plant and in the same unit for more than 30 years. The third patient had been in contact with aromatic hydrocarbons for a total of 8 years. Patient 4 had additional contact for 12 years with hydrazine, and patient 5 had been exposed for 3 years to formaldehyde.
CONCLUSION: The clustering of two cases of MF, an exceptionally rare disease, in the same plant unit, as well as the long-term, intense occupational exposure in other cases, substantiates the notion that occupational exposures may contribute to the pathogenesis of MF.

PMID: 28255994 [PubMed - indexed for MEDLINE]

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