The Impact of Klebsiella pneumoniae in Lower Gastrointestinal Tract Diseases.

The Impact of Klebsiella pneumoniae in Lower Gastrointestinal Tract Diseases.

J Dig Dis. 2018 Mar 24;:

Authors: Kaur CP, Vadivelu J, Chandramathi S

Abstract
The 2016 Global Burden of Disease report by WHO revealed that diseases of the gastrointestinal tract had one of the highest incidence rates worldwide. The plethora of factors that contribute to the development of gastrointestinal tract (GIT) related illnesses can be divided into genetic, environmental and lifestyle factors. Apart from that, the role that infectious agents play in the development of GIT diseases has piqued the interest of researchers worldwide. The human gut harbours approximately 101 to 1012 cfu/ml bacteria in it with increasing concentration towards the lower GIT. Among the various microbiota that colonize the human gut, gram-negative bacteria have been most notoriously linked to GIT related diseases such as Inflammatory bowel disease (IBD) (Crohn's disease & ulcerative colitis) and colorectal cancer (CRC). Some of the notable culprits that have been attributed to these diseases are Bacteroides fragilis (B. fragilis), Fusobacterium nucleatum (F. nucleatum), Escherichia coli (E. coli) and Helicobacter pylori (H. pylori). However, studies in recent years are beginning to recognize a new player, Klebsiella pneumoniae (K. pneumoniae) in the causation and progression of GIT diseases. Once synonymous with infections and diseases of the upper respiratory tract, K. pneumoniae has now emerged as one of the pathogens commonly isolated from patients with diseases of the GIT. However, extensive studies attributing K. pneumoniae to GIT diseases particularly that of CRC are scanty. Therefore, this review intends to shed light on the association of K. pneumoniae in gastrointestinal diseases such as Crohn's disease, IBD, ulcerative colitis as well as CRC.

PMID: 29573336 [PubMed - as supplied by publisher]

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