A Real-World Study of Dexamethasone Implant in Treatment-Naïve Patients with Diabetic Macular Edema: Efficacy and Correlation Between Inflammatory Biomarkers and Treatment Outcome:
Purpose: There has been an increasing clinical interest in specific retinal parameters as non-invasive biomarkers of retinal inflammation in diabetic macular edema (DME) that have been shown to have prognostic value, such as hyperreflective retinal fields (HRFs) and subfoveal neuroretinal detachment (SND).
Methods: We conducted a prospective, non-comparative study of treatment-naïve patients with DME to evaluate the efficacy of a Pro Re Nata (PRN) regimen of intravitreal dexamethasone implant 0.7 mg (DexI, Ozurdex™). After administration, patients underwent subsequent injections according to PRN criteria in case of edema relapse, but not earlier than 4 months after the previous treatment. Patients were evaluated at baseline, within 15 days of injection, and every month thereafter. During all visits, best-corrected visual acuity (BCVA) was recorded; central retinal thickness (CRT), type of edema, presence of SND, and presence and number of HRFs were evaluated using swept-source optical coherence tomography (SS-OCT) 3D. Treatment outcome was defined as changes in BCVA, CRT, SND and HRFs at 12 (T12) and 24 (T24) months compared with baseline (T0).
Results: The study enrolled 24 eyes of 18 patients. The mean duration of follow-up was 18± 6.6 months; for all eyes, T12 data were available, while follow-up reached T24 for 12 eyes. BCVA improved significantly and CRT decreased significantly during treatment; the edema was no longer detectable in 13/24 eyes at T12 and 8/12 eyes at T24. No patient presented SND at T12 and T24, and the mean number of HRFs decreased significantly during treatment. Results with CRT and HRFs correlated with BCVA at 12 and 24 months. No significant adverse events were observed.
Conclusion: In patients with DME, the intravitreal dexamethasone implant was effective and safe in improving both functional and tomographic parameters. This result is consistent with improvement in biomarkers of inflammation.
Keywords: dexamethasone implant, diabetic macular edema, intravitreal implants, Ozurdex, real-world, inflammation
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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- Extended right posterior liver sectionectomy for H...
- Emergency surgery for acute cholecystitis associat...
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- Serum cystatin C: A potential predictor for hospit...
- Management Strategies of Ocular Chemical Burns: Cu...
- A Real-World Study of Dexamethasone Implant in Tre...
- Collagen-Supplemented Incubation Rapidly Augments ...
- The effect of vitamin D supplementation on surviva...
- Cytotoxic CD8+ T cells in cancer and cancer immuno...
- Autophagy as a therapeutic target in pancreatic ca...
- Can Straw Phonation Be Considered As Vocal Warm Up...
- Extraarticular extrasynovial solitary osteochondro...
- Neural Correlates of Sleep Recovery following Mela...
- Subjects with temporomandibular joint disc displac...
- defective endocytosis and proximal tubule dysfunct...
- Uncaria tomentosa reduces osteoclastic bone loss
- Intestinal resection affects whole-body arginine s...
- Understanding the mechanisms of placebo and nocebo...
- Prognostic Factors, Treatment, and Survival in Pri...
- Use of Autologous, Noncultured Melanocyte–Keratino...
- Guidance for the Management of Patients with Vascu...
- Strip Graft of the Eyebrow for the Treatment of Tr...
- A Large Defect on the Cheek
- Robust Single-Stage Reconstruction of the Mid and ...
- Vulvar Lichen Sclerosus: Consider Treatment With H...
- Temporary Greater Auricular Nerve Paresthesia Afte...
- Electron Microscopy of Argyria Treated With Picose...
- The Perialar Crescentic Advancement Flap: A Workho...
- Depth Map for Face and Neck Deep Chemical Peel Res...
- Catamenial Exacerbations of Cutaneous Neoplasms
- High- Versus Low-Density Fractional Laser in the T...
- Nanosecond Pulsed Electric Field Treatment of Sebo...
- Use of Lasers for Iron-Induced Accidental Tattoos:...
- Effects of Hyaluronic Acid on Stability of Bleomyc...
- The Force Required to Inject a Column of Filler Th...
- Reliability of Periocular Anthropometry: A Compari...
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