Imidazole: An essential edifice for the identification of new lead compounds and drug development.

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Imidazole: An essential edifice for the identification of new lead compounds and drug development.

Mini Rev Med Chem. 2017 Feb 28;:

Authors: Shalmali N, Ali MR, Bawa S

Abstract
In recent years, a drastic rise has been observed in incidences of resistance, low efficacy rates and toxicities to various drugs used in therapeutic application. It has been observed that presence of imidazole nucleus in several categories of therapeutic agents such as antimicrobials, antivirals, antiparasites, anticancer, anti-inflammatory, antidiabetics etc. has made it a vital anchor for the development of new therapeutic agents. But, there is a need to couple the newest information with the already available knowledge to recognize the present standing of imidazole motif in medicinal chemistry research. In the present review, importance of this nucleus in some less explored activities like antimalarial and anthelmintics is mentioned along with well explored fields like cancer. Substitution pattern around imidazole nucleus is discussed here with an aim to help medicinal chemists for the development of SAR of imidazole based compounds for each activity. This discussion will further help in the advancement of existing imidazole derivatives and in the generation of new and safe imidazole compounds.

PMID: 28245779 [PubMed - as supplied by publisher]

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