Related Articles The mystery of the ketogenic diet: benevolent pseudo-diabetes. Cell Cycle. 2019 09;18(18):2157-2163 Authors: Blagosklonny MV Abstract Designed a century ago to treat epilepsy, the ketogenic diet (KD) is also effective against obesity and diabetes. Paradoxically, some studies in rodents have found that the KD seemingly causes diabetes, contradicting solid clinical data in humans. This paradox can be resolved by applying the...
Wed Sep 02, 2020 14:47
Related Articles Promising predictors of checkpoint inhibitor response in NSCLC. Expert Rev Anticancer Ther. 2020 Sep 01;: Authors: Alex F, Alfredo A Abstract INTRODUCTION: The development of immune-checkpoint inhibitors targeting the programmed death-1 (PD-1) and its ligand (PD-L1) axis has transformed the treatment paradigm in non-small-cell lung cancer, bringing about unprecedented 5-year survival rates. Despite this dramatic improvement,...
Wed Sep 02, 2020 15:39
Related Articles A drug screening toolkit based on the -1 ribosomal frameshifting of SARS-CoV-2. Heliyon. 2020 Aug;6(8):e04793 Authors: Chen Y, Tao H, Shen S, Miao Z, Li L, Jia Y, Zhang H, Bai X, Fu X Abstract The -1 ribosomal frameshifting is vital for the translation of the open reading frame (ORF)1b in SARS-CoV-2. The products of ORF1b participate in viral replication. Therefore, changing the frameshift frequency reduces the survival of the...
Wed Sep 02, 2020 13:44
Related Articles Thorough survey and analysis of pulmonary lymphoepithelioma-like carcinoma in Macau and multimodality treatment for advanced disease. Lung Cancer. 2019 12;138:116-123 Authors: Zhou N, Lin Y, Peng X, Wang Y, Wang Y Abstract OBJECTIVE: Pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare type of non-small cell lung cancer. The clinical course and prognosis of advanced LELC are largely unknown. Few reports have discussed...
Wed Sep 02, 2020 13:24
Related Articles Exploring the dietary protein intake and skeletal muscle during first-line anti-neoplastic treatment in patients with non-small cell lung cancer. Clin Nutr ESPEN. 2019 12;34:94-100 Authors: Tobberup R, Rasmussen HH, Holst M, Jensen NA, Falkmer UG, Bøgsted M, Delekta AM, Carus A Abstract BACKGROUND: Loss of skeletal muscle mass is the corner stone of cancer cachexia, but no effective therapies are yet identified. The optimal...
Wed Sep 02, 2020 13:24
Related Articles Stereotactic body radiotherapy versus percutaneous local tumor ablation for early-stage non-small cell lung cancer. Lung Cancer. 2019 12;138:6-12 Authors: Ager BJ, Wells SM, Gruhl JD, Stoddard GJ, Tao R, Kokeny KE, Hitchcock YJ Abstract OBJECTIVES: To compare patterns of care and overall survival (OS) between stereotactic body radiotherapy (SBRT) and percutaneous local tumor ablation (LTA) for non-surgically managed early-stage...
Wed Sep 02, 2020 13:24
Related Articles Parental caregiving trajectories and Metabolic Syndrome: A longitudinal study among Chinese women. Soc Sci Med. 2019 11;240:112559 Authors: Lu X, Dallal CM, He X, Juon HS, Wang MQ, Lee S Abstract Caregiving stress may play a role in the pathogenesis of Metabolic Syndrome (MetS). However, few studies have investigated the consequences of caregiving on this objectively measured health outcome. This study used population based...
Wed Sep 02, 2020 13:24
Related Articles HER2 immunohistochemistry staining positivity is strongly predictive of tumor response to neoadjuvant chemotherapy in HER2 positive breast cancer. Pathol Res Pract. 2020 Aug 10;216(11):153155 Authors: Zhao J, Krishnamurti U, Zhang C, Meisel J, Wei Z, Suo A, Aneja R, Li Z, Li X Abstract BACKGROUND: The current recommendation is to reflex test HER2 immunohistochemistry (IHC) equivocal breast cancer cases with fluorescence in situ...
Wed Sep 02, 2020 15:11
Related Articles Biomarkers in Breast Cancer: An Integrated Analysis of Comprehensive Genomic Profiling and PD-L1 Immunohistochemistry Biomarkers in 312 Patients with Breast Cancer. Oncologist. 2020 Sep 01;: Authors: Huang RSP, Li X, Haberberger J, Sokol E, Severson E, Duncan DL, Hemmerich A, Edgerly C, Ferguson NL, Williams E, Elvin J, Vergilio JA, Killian JK, Lin D, Hiemenz M, Xiao J, McEwan D, Holmes O, Danziger N, Erlich R, Frampton G, Cohen MB, McGregor...
Wed Sep 02, 2020 15:11
Related Articles Lower response to trastuzumab emtansine in metastatic breast cancer patients with human epidermal growth factor receptor 2 immunohistochemistry score of 2 and fluorescence in situ hybridization positive compared with immunohistochemistry score of 3: a retrospective study. Anticancer Drugs. 2020 Aug 27;: Authors: Yazaki S, Hashimoto J, Ogita S, Nakano E, Suzuki K, Yamauchi T Abstract BACKGROUND: Tumor human epidermal growth factor...
Wed Sep 02, 2020 15:11
Related Articles An optimal acquisition and post-processing pipeline for hybrid IVIM-DKI in head and neck. Magn Reson Med. 2020 Aug 31;: Authors: Sijtsema ND, Petit SF, Poot DHJ, Verduijn GM, van der Lugt A, Hoogeman MS, Hernandez-Tamames JA Abstract PURPOSE: To optimize the diffusion-weighting b values and postprocessing pipeline for hybrid intravoxel incoherent motion diffusion kurtosis imaging in the head and neck region. METHODS:...
Wed Sep 02, 2020 13:04
Related Articles An Operational Clinical Approach in the Diagnosis and Management of Sleep Bruxism: A First Step Towards Validation. J Oral Facial Pain Headache. 2020 Summer;34(3):236-239 Authors: Cunha TCA, Dal Fabbro C, Januzzi E, Cunali PA, Meira E Cruz M Abstract Exacerbation of nighttime sleep-related oromotor activity is often recognized as a relevant clinical entity commonly known as sleep bruxism (SB). Many pragmatic issues about SB...
Wed Sep 02, 2020 13:54
Related Articles Knowledge, attitude, and clinical practice of dentists toward obstructive sleep apnea: A literature review. Cranio. 2020 Sep 01;:1-7 Authors: Nguyen VT Abstract OBJECTIVE: To review the knowledge, attitude, and clinical practice of dentists and dental specialists toward obstructive sleep apnea (OSA). METHODS: A literature search was performed on PubMed and ScienceDirect databases. Peer-reviewed English publications...
Wed Sep 02, 2020 13:54
Related Articles Obstructive sleep apnea and respiratory center regulation abnormality. Sleep Breath. 2020 Sep 01;: Authors: Si L, Zhang J, Wang Y, Cao J, Chen BY, Guo HJ Abstract PURPOSE: Obstructive sleep apnea (OSA) is a complex disease in which phenotypic analysis and understanding pathological mechanisms facilitate personalized treatment and outcomes. However, the pathophysiology responsible for this robust observation is incompletely understood....
Wed Sep 02, 2020 13:54
Related Articles Benefits and Risks of Bariatric Surgery in Adults: A Review. JAMA. 2020 Sep 01;324(9):879-887 Authors: Arterburn DE, Telem DA, Kushner RF, Courcoulas AP Abstract Importance: Severe obesity and its related diseases, such as type 2 diabetes, hypertension, dyslipidemia, and sleep apnea, are very common in the United States, but currently very few patients with these conditions choose to undergo bariatric surgery. Summaries of the...
Wed Sep 02, 2020 13:54
Related Articles Self-reported physical health status of donor sperm-conceived adults. J Dev Orig Health Dis. 2020 Aug 28;:1-14 Authors: Adams DH, Gerace A, Davies MJ, de Lacey S Abstract Donor-conceived neonates have poorer birth outcomes, including low birth weight and preterm delivery that are associated with poorer long-term health in adulthood through the developmental origins of health and disease (DOHaD) theory. The aim of this study...
Wed Sep 02, 2020 13:54
Related Articles Efficacy and long-term follow-up of positional therapy by vibrotactile neck-based device in the management of positional OSA. J Clin Sleep Med. 2020 Jul 06;: Authors: De Corso E, Mastrapasqua RF, Fiorita A, Settimi S, Mele DA, Picciotti PM, Loperfido A, Marrone S, Rizzotto G, Paludetti G, Scarano E Abstract STUDY OBJECTIVES: Different therapeutic strategies have been investigated for the treatment of positional-OSA (POSA), but...
Wed Sep 02, 2020 13:54
Related Articles An assessment of risks associated with obstructive sleep apnea and its relationship with adverse health outcomes among pregnant women. A multi-hospital based study. Adv Respir Med. 2020;88(4):327-334 Authors: Joseph N, Shreeshaina S, Bhat SL, Gundi VK, Bharghav MHS, Shreyashree SB Abstract INTRODUCTION: Physiological changes in pregnancy increase the vulnerability of antenatal women to develop obstructive sleep apnoea (OSA)....
Wed Sep 02, 2020 13:54
Related Articles Differences of Craniofacial Characteristics in Oral Breathing and Pediatric OSA. J Craniofac Surg. 2020 Aug 28;: Authors: Feng G, Gong X, Yu M, Huang X, Gao X Abstract BACKGROUND: Oral breathing (OB) was considered associated with specific craniofacial structures and same for pediatric obstructive sleep apnea (OSA). This study aimed to investigate the differences of craniofacial structures between OB and OSA. METHODS:...
Wed Sep 02, 2020 13:54
Related Articles Vision Loss From Giant Cell Arteritis in Patients With Other Ocular Diagnoses. J Neuroophthalmol. 2020 Aug 28;: Authors: Nichani P, Biousse V, Newman NJ, Micieli JA Abstract Vision problems from giant cell arteritis (GCA) can be difficult to diagnose as patients may present with vision loss in the absence of systemic symptoms, have other comorbidities that affect inflammatory blood markers, or have other ocular diagnoses. We...
Wed Sep 02, 2020 13:54
Related Articles Does obstructive sleep apnoea contribute to obesity, hypertension and kidney dysfunction in children? A systematic review protocol. BMJ Open. 2020 Aug 30;10(8):e039342 Authors: Rodriguez-Lopez S, Palkowski S, Gerdung C, Keto-Lambert D, Sebastianski M, Castro-Codesal ML Abstract INTRODUCTION: Childhood obstructive sleep apnoea (OSA) is a highly prevalent disorder that may directly contribute to the development of obesity, hypertension...
Wed Sep 02, 2020 13:54
Related Articles Sleep characteristics and HbA1c in patients with type 2 diabetes on glucose-lowering medication. BMJ Open Diabetes Res Care. 2020 08;8(1): Authors: Tan X, Benedict C Abstract INTRODUCTION: To examine the association of sleep duration, insomnia, and obstructive sleep apnea (OSA) with hemoglobin A1c (HbA1c) in a cohort of patients with type 2 diabetes (T2D) on glucose-lowering medications. RESEARCH DESIGN AND METHODS:...
Wed Sep 02, 2020 13:54
Related Articles Are reduced internal nasal dimensions a risk factor for obstructive sleep apnea syndrome? Braz J Otorhinolaryngol. 2020 Jul 30;: Authors: Trindade SHK, Trindade IEK, Silva ASCD, Araújo BMAM, Trindade-Suedam IK, Sampaio-Teixeira ACM, Weber SAT Abstract INTRODUCTION: Obstructive sleep apnea syndrome is a high-prevalence disorder found in the population. Studies have shown a possible association between nasal obstruction and obstructive...
Wed Sep 02, 2020 13:54
Related Articles Sleep-Disordered Breathing and Airway Assessment Using Polysomnography in Pediatric Patients With Craniofacial Disorders. J Craniofac Surg. 2020 May/Jun;31(3):720-726 Authors: Bekisz JM, Wang MM, Rickert SM, Rodriguez AJ, Flores RL Abstract Children with cleft and craniofacial conditions commonly present with concurrent airway anomalies, which often manifest as sleep disordered breathing. Craniofacial surgeons and members of...
Wed Sep 02, 2020 13:54
Related Articles Comparison of dental arch measurements according to the grade and the obstructive character of adenoids. Int Orthod. 2019 06;17(2):333-341 Authors: Diouf JS, Ouédraogo Y, Souaré N, Badiane A, Diop-Bâ K, Ngom PI, Zouaki A, Diagne F Abstract INTRODUCTION: Obstructive adenoid hypertrophy is cited as one of the causes of mouth breathing and leads to disharmony in the development of orofacial structures. The objective of this study...
Wed Sep 02, 2020 13:54
Related Articles Influence of age and gender on sleep bruxism and snoring in non-apneic snoring patients: A polysomnographic study. J Sleep Res. 2020 Sep 01;:e13178 Authors: Smardz J, Wieckiewicz M, Gac P, Poreba R, Wojakowska A, Mazur G, Martynowicz H Abstract The present study aimed to assess the influence of gender and age on snoring and sleep bruxism in non-apneic snoring patients. Adult participants with clinical suspicion of snoring and...
Wed Sep 02, 2020 15:43
[Study on the relationship between sleep-related problems and dyslipidemia among adults in Beijing].
Related Articles [Study on the relationship between sleep-related problems and dyslipidemia among adults in Beijing]. Zhonghua Liu Xing Bing Xue Za Zhi. 2020 Aug 10;41(8):1250-1255 Authors: Ma AJ, Fang K, Wei YQ, Jiang B, Dong J, Xie C, Dong Z Abstract Objective: To investigate the status quo of sleelated problems and relationship with dyslipidemia among adults in Beijing. Methods: From August to December 2017, 13 188 residents aged 18-79 years...
Wed Sep 02, 2020 15:43
Related Articles INTERCOMPARISON ON INTERNAL DOSE ASSESSMENT FOR NUCLEAR POWER PLANTS IN KOREA. Radiat Prot Dosimetry. 2019 Dec 31;186(4):524-529 Authors: Kim SY Abstract The intercomparison test is a quality assurance activity performed for internal dose assessment. In Korea, the intercomparison test on internal dose assessment was carried out for nuclear facilities in May 2018. The test involved four nuclear facilities in Korea, and seven...
Wed Sep 02, 2020 15:10
Related Articles Evaluation of trigeminal nerve tractography using two-fold-accelerated simultaneous multi-slice readout-segmented echo planar diffusion tensor imaging. Eur Radiol. 2020 Sep 01;: Authors: Koh YH, Shih YC, Lim SL, Kiew YS, Lim EW, Ng SM, Ooi LQR, Tan WQ, Chung YC, Rumpel H, Tan EK, Chan LL Abstract OBJECTIVES: Simultaneous multi-slice (SMS) imaging with short repetition time (TR) accelerates diffusion tensor imaging (DTI) acquisitions....
Wed Sep 02, 2020 15:46
Related Articles Inferior Meatus Mucosal Flap for Septal Reconstruction and Resurfacing After Nasoseptal Flap Harvest. Laryngoscope. 2020 Sep 01;: Authors: Ruffner R, Pereira MC, Patel V, Peris-Celda M, Pinheiro-Neto CD PMID: 32869861 [PubMed - as supplied by publisher]
Wed Sep 02, 2020 15:46
Related Articles Skull Base Sphenoid Bone: A Potential Route of Brain Abscesses Induced by Odontogenic Infection. J Craniofac Surg. 2020 Aug 28;: Authors: Lou Y, Feng B, Hong H, Ying B, Yu M, Wang H Abstract Odontogenic foci are rarely linked with brain abscesses. The lack of an effective approach to match the causative origin with the infection can lead to late medical response of patients. Here we present a case of a 53-year-old man with brain...
Wed Sep 02, 2020 15:46
Related Articles Targeting Chemosensory Ion Channels in Peripheral Swallowing-Related Regions for the Management of Oropharyngeal Dysphagia. Int J Mol Sci. 2020 Aug 27;21(17): Authors: Hossain MZ, Ando H, Unno S, Kitagawa J Abstract Oropharyngeal dysphagia, or difficulty in swallowing, is a major health problem that can lead to serious complications, such as pulmonary aspiration, malnutrition, dehydration, and pneumonia. The current clinical...
Wed Sep 02, 2020 18:25
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