IJMS, Vol. 21, Pages 6393: Ceramic Scaffolds in a Vacuum Suction Handle for Intraoperative Stromal Cell Enrichment International Journal of Molecular Sciences doi: 10.3390/ijms21176393 Authors: André Busch Monika Herten Marcel Haversath Christel Kaiser Sven Brandau Marcus Jäger During total joint replacement, high concentrations of mesenchymal stromal cells (MSCs) are released at the implantation site. They can be found in cell–tissue composites (CTC) that are...
Wed Sep 02, 2020 03:00
IJMS, Vol. 21, Pages 6394: Drug Repurposing in Dentistry; towards Application of Small Molecules in Dentin Repair International Journal of Molecular Sciences doi: 10.3390/ijms21176394 Authors: Anahid A. Birjandi Fernanda R. Suzano Paul T. Sharpe One of the main goals of dentistry is the natural preservation of the tooth structure following damage. This is particularly implicated in deep dental cavities affecting dentin and pulp, where odontoblast survival is jeopardized. This activates...
Wed Sep 02, 2020 03:00
IJMS, Vol. 21, Pages 6384: Co-Occurrence of Hepatitis A Infection and Chronic Liver Disease International Journal of Molecular Sciences doi: 10.3390/ijms21176384 Authors: Tatsuo Kanda Reina Sasaki Ryota Masuzaki Hiroshi Takahashi Taku Mizutani Naoki Matsumoto Kazushige Nirei Mitsuhiko Moriyama Hepatitis A virus (HAV) infection occasionally leads to a critical condition in patients with or without chronic liver diseases. Acute-on-chronic liver disease includes acute-on-chronic...
Wed Sep 02, 2020 03:00
IJMS, Vol. 21, Pages 6391: Silencing PROK2 Inhibits Invasion of Human Cervical Cancer Cells by Targeting MMP15 Expression International Journal of Molecular Sciences doi: 10.3390/ijms21176391 Authors: Min-Hua Wu Pei-Ru Wu Yi-Hsien Hsieh Chia-Liang Lin Chung-Jung Liu Tsung-Ho Ying Cervical cancer is the second most frequent type of gynecologic cancer worldwide. Prokineticin 2 (PROK2) is reported to be involved in tumor progression in some malignant tumors. However, the...
Wed Sep 02, 2020 03:00
IJMS, Vol. 21, Pages 6392: Endogenous Chemerin from PVAT Amplifies Electrical Field-Stimulated Arterial Contraction: Use of the Chemerin Knockout Rat International Journal of Molecular Sciences doi: 10.3390/ijms21176392 Authors: Emma D Flood Stephanie W Watts Background: We previously reported that the adipokine chemerin, when added exogenously to the isolated rat mesenteric artery, amplified electrical field-stimulated (EFS) contraction. The Chemerin1 antagonist CCX832 alone inhibited...
Wed Sep 02, 2020 03:00
IJMS, Vol. 21, Pages 6390: Decreased Urinary Levels of SIRT1 as Non-Invasive Biomarker of Early Renal Damage in Hypertension International Journal of Molecular Sciences doi: 10.3390/ijms21176390 Authors: Olga Martinez-Arroyo Ana Ortega Miriam Galera Elena Solaz Sergio Martinez-Hervas Josep Redon Raquel Cortes Sirtuins have become important players in renal damage in hypertension and diabetes, but their value as biomarkers is poorly assessed. The aims of the study were...
Wed Sep 02, 2020 03:00
IJMS, Vol. 21, Pages 6388: Human Cell Modeling for Cardiovascular Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21176388 Authors: Melania Lippi Ilaria Stadiotti Giulio Pompilio Elena Sommariva The availability of appropriate and reliable in vitro cell models recapitulating human cardiovascular diseases has been the aim of numerous researchers, in order to retrace pathologic phenotypes, elucidate molecular mechanisms, and discover therapies using simple...
Wed Sep 02, 2020 03:00
IJMS, Vol. 21, Pages 6387: Siloxanes—Versatile Materials for Surface Functionalisation and Graft Copolymers International Journal of Molecular Sciences doi: 10.3390/ijms21176387 Authors: Karolina Glosz Agnieszka Stolarczyk Tomasz Jarosz Siloxanes are adaptable species that have found extensive applications as versatile materials for functionalising various surfaces and as building blocks for polymers and hybrid organic-inorganic systems. The primary goal of this review is to report...
Wed Sep 02, 2020 03:00
IJMS, Vol. 21, Pages 6386: Intraductal Pancreatic Mucinous Neoplasms: A Tumor-Biology Based Approach for Risk Stratification International Journal of Molecular Sciences doi: 10.3390/ijms21176386 Authors: Vincenzo Nasca Marta Chiaravalli Geny Piro Annachiara Esposito Lisa Salvatore Giampaolo Tortora Vincenzo Corbo Carmine Carbone Pancreatic ductal adenocarcinoma is one of the most lethal human cancers. Its precursor lesions include pancreatic intra-epithelial neoplasia,...
Wed Sep 02, 2020 03:00
IJMS, Vol. 21, Pages 6389: verA Gene is Involved in the Step to Make the Xanthone Structure of Demethylsterigmatocystin in Aflatoxin Biosynthesis International Journal of Molecular Sciences doi: 10.3390/ijms21176389 Authors: Hongmei Zeng Jingjing Cai Hidemi Hatabayashi Hiroyuki Nakagawa Hiromitsu Nakajima Kimiko Yabe In the biosynthesis of aflatoxin, verA, ver-1, ordB, and hypA genes of the aflatoxin gene cluster are involved in the pathway from versicolorin A (VA) to...
Wed Sep 02, 2020 03:00
IJMS, Vol. 21, Pages 6385: Cell Type-specific Imaging of Calcium Signaling in Arabidopsis thaliana Seedling Roots Using GCaMP3 International Journal of Molecular Sciences doi: 10.3390/ijms21176385 Authors: William Krogman J. Alan Sparks Elison B. Blancaflor Cytoplasmic calcium ([Ca2+]cyt) is a well-characterized second messenger in eukaryotic cells. An elevation in [Ca2+]cyt levels is one of the earliest responses in plant cells after exposure to a range of environmental stimuli....
Wed Sep 02, 2020 03:00
IJMS, Vol. 21, Pages 6382: Antimicrobial and Amyloidogenic Activity of Peptides Synthesized on the Basis of the Ribosomal S1 Protein from Thermus Thermophilus International Journal of Molecular Sciences doi: 10.3390/ijms21176382 Authors: Stanislav R. Kurpe Sergei Yu. Grishin Alexey K. Surin Olga M. Selivanova Roman S. Fadeev Ylyana F. Dzhus Elena Yu. Gorbunova Leila G. Mustaeva Vyacheslav N. Azev Oxana V. Galzitskaya Controlling the aggregation of vital bacterial...
Wed Sep 02, 2020 03:00
IJMS, Vol. 21, Pages 6375: Evidence of Skin Barrier Damage by Cyclic Siloxanes (Silicones)—Using Digital Holographic Microscopy International Journal of Molecular Sciences doi: 10.3390/ijms21176375 Authors: Krystyna Mojsiewicz-Pieńkowska Ewa Stachowska Dominika Krenczkowska Dagmara Bazar Frans Meijer Cyclic siloxanes (D4, D5, D6) are widely used in skin products. They improve skin sensory properties and alleviate dry skin, but there is still one report (published 2019), which...
Wed Sep 02, 2020 03:00
IJMS, Vol. 21, Pages 6383: USP14 Regulates DNA Damage Response and Is a Target for Radiosensitization in Non-Small Cell Lung Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21176383 Authors: Arishya Sharma Alexandru Almasan Non-small cell lung cancer (NSCLC) represents ~85% of the lung cancer cases. Despite recent advances in NSCLC treatment, the five-year survival rate is still around 23%. Radiotherapy is indicated in the treatment of both early and advanced stage...
Wed Sep 02, 2020 03:00
IJMS, Vol. 21, Pages 6379: Airway Inflammation and Host Responses in the Era of CFTR Modulators International Journal of Molecular Sciences doi: 10.3390/ijms21176379 Authors: Karen Keown Ryan Brown Declan F. Doherty Claire Houston Michael C. McKelvey Shannice Creane Dermot Linden Daniel F. McAuley Joseph C. Kidney Sinéad Weldon Damian G. Downey Clifford C. Taggart The arrival of cystic fibrosis transmembrane conductance regulator (CFTR) modulators as...
Wed Sep 02, 2020 03:00
IJMS, Vol. 21, Pages 6380: Stimulus-Responsive Nanomedicines for Disease Diagnosis and Treatment International Journal of Molecular Sciences doi: 10.3390/ijms21176380 Authors: Gengqi Liu Jonathan F. Lovell Lei Zhang Yumiao Zhang Stimulus-responsive drug delivery systems generally aim to release the active pharmaceutical ingredient (API) in response to specific conditions and have recently been explored for disease treatments. These approaches can also be extended to molecular...
Wed Sep 02, 2020 03:00
IJMS, Vol. 21, Pages 6381: The Metabolic Reprogramming Induced by Sub-optimal Nutritional and Light Inputs in Soilless Cultivated Green and Red Butterhead Lettuce International Journal of Molecular Sciences doi: 10.3390/ijms21176381 Authors: Begoña Miras-Moreno Giandomenico Corrado Leilei Zhang Biancamaria Senizza Laura Righetti Renato Bruni Christophe El-Nakhel Maria Isabella Sifola Antonio Pannico Stefania De Pascale Youssef Rouphael Luigi Lucini Sub-optimal...
Wed Sep 02, 2020 03:00
IJMS, Vol. 21, Pages 6378: Local and Systemic Changes in Photosynthetic Parameters and Antioxidant Activity in Cucumber Challenged with Pseudomonas syringae pv lachrymans International Journal of Molecular Sciences doi: 10.3390/ijms21176378 Authors: Tomasz Kopczewski Elżbieta Kuźniak Andrzej Kornaś Grzegorz Rut Michał Nosek Iwona Ciereszko Lech Szczepaniak We studied changes in gas exchange, photochemical activity and the antioxidant system in cucumber leaves locally...
Wed Sep 02, 2020 03:00
IJMS, Vol. 21, Pages 6376: MBNL1-Associated Mitochondrial Dysfunction and Apoptosis in C2C12 Myotubes and Mouse Skeletal Muscle International Journal of Molecular Sciences doi: 10.3390/ijms21176376 Authors: Shingo Yokoyama Yoshitaka Ohno Tatsuro Egawa Kazuya Ohashi Rika Ito Huascar Pedro Ortuste Quiroga Tomohiro Yamashita Katsumasa Goto We explored the interrelationship between a tissue-specific alternative splicing factor muscleblind-like 1 (MBNL1) and peroxisome...
Wed Sep 02, 2020 03:00
IJMS, Vol. 21, Pages 6377: The Influence of Radiation on Bone and Bone Cells—Differential Effects on Osteoclasts and Osteoblasts International Journal of Molecular Sciences doi: 10.3390/ijms21176377 Authors: Anna-Jasmina Donaubauer Lisa Deloch Ina Becker Rainer Fietkau Benjamin Frey Udo S. Gaipl The bone is a complex organ that is dependent on a tight regulation between bone formation by osteoblasts (OBs) and bone resorption by osteoclasts (OCs). These processes can be...
Wed Sep 02, 2020 03:00
IJMS, Vol. 21, Pages 6367: Towards Mimicking the Fetal Liver Niche: The Influence of Elasticity and Oxygen Tension on Hematopoietic Stem/Progenitor Cells Cultured in 3D Fibrin Hydrogels International Journal of Molecular Sciences doi: 10.3390/ijms21176367 Authors: Christian Garcia-Abrego Samantha Zaunz Burak Toprakhisar Ramesh Subramani Olivier Deschaume Stijn Jooken Manmohan Bajaj Herman Ramon Catherine Verfaillie Carmen Bartic Jennifer Patterson Hematopoietic...
Wed Sep 02, 2020 03:00
IJMS, Vol. 21, Pages 6374: Transient Receptor Potential (TRP) Channels in Head-and-Neck Squamous Cell Carcinomas: Diagnostic, Prognostic, and Therapeutic Potentials International Journal of Molecular Sciences doi: 10.3390/ijms21176374 Authors: Fruzsina Kiss Krisztina Pohóczky Arpad Szállási Zsuzsanna Helyes Head-and-neck squamous cell carcinomas (HNSCC) remain a leading cause of cancer morbidity and mortality worldwide. This is a largely preventable disease with smoking, alcohol...
Wed Sep 02, 2020 03:00
IJMS, Vol. 21, Pages 6368: Fusion Potential of Human Osteoclasts In Vitro Reflects Age, Menopause, and In Vivo Bone Resorption Levels of Their Donors—A Possible Involvement of DC-STAMP International Journal of Molecular Sciences doi: 10.3390/ijms21176368 Authors: Anaïs M. J. Møller Jean-Marie Delaissé Jacob B. Olesen Luisa M. Canto Silvia R. Rogatto Jonna S. Madsen Kent Søe It is well established that multinucleation is central for osteoclastic bone resorption. However,...
Wed Sep 02, 2020 03:00
IJMS, Vol. 21, Pages 6371: Proteomic Characterization of the Olfactory Molecular Imbalance in Dementia with Lewy Bodies International Journal of Molecular Sciences doi: 10.3390/ijms21176371 Authors: Mercedes Lachén-Montes Naroa Mendizuri Domitille Schvartz Joaquín Fernández-Irigoyen Jean Charles Sánchez Enrique Santamaría Olfactory dysfunction is one of the prodromal symptoms in dementia with Lewy bodies (DLB). However, the molecular pathogenesis associated with decreased...
Wed Sep 02, 2020 03:00
IJMS, Vol. 21, Pages 6372: Decoding Susceptibility to Respiratory Viral Infections and Asthma Inception in Children International Journal of Molecular Sciences doi: 10.3390/ijms21176372 Authors: James F. Read Anthony Bosco Human Respiratory Syncytial Virus and Human Rhinovirus are the most frequent cause of respiratory tract infections in infants and children and are major triggers of acute viral bronchiolitis, wheezing and asthma exacerbations. Here, we will discuss the application...
Wed Sep 02, 2020 03:00
IJMS, Vol. 21, Pages 6373: Developing Electron Microscopy Tools for Profiling Plasma Lipoproteins Using Methyl Cellulose Embedment, Machine Learning and Immunodetection of Apolipoprotein B and Apolipoprotein(a) International Journal of Molecular Sciences doi: 10.3390/ijms21176373 Authors: Yvonne Giesecke Samuel Soete Katarzyna MacKinnon Thanasis Tsiaras Madeline Ward Mohammed Althobaiti Tamas Suveges James E. Lucocq Stephen J. McKenna John M. Lucocq Plasma...
Wed Sep 02, 2020 03:00
IJMS, Vol. 21, Pages 6370: High-Throughput Cloning and Characterization of Emerging Adenovirus Types 70, 73, 74, and 75 International Journal of Molecular Sciences doi: 10.3390/ijms21176370 Authors: Wenli Zhang Kemal Mese Sebastian Schellhorn Nora Bahlmann Nicolas Mach Oskar Bunz Akshay Dhingra Elias Hage Marie-Edith Lafon Harald Wodrich Albert Heim Anja Ehrhardt Recently an increasing number of new adenovirus types associated with type-dependent pathogenicity...
Wed Sep 02, 2020 03:00
IJMS, Vol. 21, Pages 6362: Tissue Adaptation to Environmental Cues by Symmetric and Asymmetric Division Modes of Intestinal Stem Cells International Journal of Molecular Sciences doi: 10.3390/ijms21176362 Authors: Aurélia Joly Raphaël Rousset Tissues must adapt to the different external stimuli so that organisms can survive in their environments. The intestine is a vital organ involved in food processing and absorption, as well as in innate immune response. Its adaptation to environmental...
Wed Sep 02, 2020 03:00
IJMS, Vol. 21, Pages 6369: Novel Nanocomposite Inhibiting Caries at the Enamel Restoration Margins in an In Vitro Saliva-Derived Biofilm Secondary Caries Model International Journal of Molecular Sciences doi: 10.3390/ijms21176369 Authors: Wen Zhou Xinyu Peng Xuedong Zhou Andrea Bonavente Michael D. Weir Mary Anne S. Melo Satoshi Imazato Thomas W. Oates Lei Cheng Hockin H. K. Xu Secondary caries often occurs at the tooth-composite margins. This study developed...
Wed Sep 02, 2020 03:00
IJMS, Vol. 21, Pages 6366: Hepatitis B Virus preS/S Truncation Mutant rtM204I/sW196* Increases Carcinogenesis through Deregulated HIF1A, MGST2, and TGFbi International Journal of Molecular Sciences doi: 10.3390/ijms21176366 Authors: Ming-Wei Lai Kung-Hao Liang Chau-Ting Yeh Inevitable long-term therapy with nucleos(t)ide analogs in patients with chronic hepatitis B virus (HBV) infection has selected reverse-transcriptase (rt) mutants in a substantial proportion of patients. Some...
Wed Sep 02, 2020 03:00
IJMS, Vol. 21, Pages 6365: Challenges in Promoting Mitochondrial Transplantation Therapy International Journal of Molecular Sciences doi: 10.3390/ijms21176365 Authors: Yuma Yamada Momo Ito Manae Arai Mitsue Hibino Takao Tsujioka Hideyoshi Harashima Mitochondrial transplantation therapy is an innovative strategy for the treatment of mitochondrial dysfunction. The approach has been reported to be useful in the treatment of cardiac ischemic reperfusion injuries in human clinical...
Wed Sep 02, 2020 03:00
IJMS, Vol. 21, Pages 6364: Prediction Power on Cardiovascular Disease of Neuroimmune Guidance Cues Expression by Peripheral Blood Monocytes Determined by Machine-Learning Methods International Journal of Molecular Sciences doi: 10.3390/ijms21176364 Authors: Huayu Zhang Edwin O. W. Bredewold Dianne Vreeken Jacques. M. G. J. Duijs Hetty C. de Boer Adriaan O. Kraaijeveld J. Wouter Jukema Nico H. Pijls Johannes Waltenberger Erik A.L. Biessen Eric P. van der Veer Anton...
Wed Sep 02, 2020 03:00
IJMS, Vol. 21, Pages 6363: Levels of Interleukin-6 in Saliva, but Not Plasma, Correlate with Clinical Metrics in Huntington’s Disease Patients and Healthy Control Subjects International Journal of Molecular Sciences doi: 10.3390/ijms21176363 Authors: Jody Corey-Bloom Ryan S. Fischer Aeri Kim Chase Snell Georgia M. Parkin Douglas A. Granger Steven W. Granger Elizabeth A. Thomas Growing evidence suggests that inflammatory responses, in both the brain and peripheral...
Wed Sep 02, 2020 03:00
IJMS, Vol. 21, Pages 6361: A Novel KRAS Antibody Highlights a Regulation Mechanism of Post-Translational Modifications of KRAS during Tumorigenesis International Journal of Molecular Sciences doi: 10.3390/ijms21176361 Authors: Mohamad Assi Boris Pirlot Vincent Stroobant Jean-Paul Thissen Patrick Jacquemin KRAS is a powerful oncogene responsible for the development of many cancers. Despite the great progress in understanding its function during the last decade, the study of...
Wed Sep 02, 2020 03:00
IJMS, Vol. 21, Pages 6359: Differential Impact of Calcitriol and Its Analogs on Tumor Stroma in Young and Aged Ovariectomized Mice Bearing 4T1 Mammary Gland Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21176359 Authors: Artur Anisiewicz Agata Pawlik Beata Filip-Psurska Joanna Wietrzyk (1) Background: Vitamin D compounds (VDC) are extensively studied in the field of anticancer properties, including breast cancer. Previously, we showed that calcitriol and...
Wed Sep 02, 2020 03:00
IJMS, Vol. 21, Pages 6360: How Long Are Reperfusion Therapies Beneficial for Patients after Stroke Onset? Lessons from Lethal Ischemia Following Early Reperfusion in a Mouse Model of Stroke International Journal of Molecular Sciences doi: 10.3390/ijms21176360 Authors: Takayuki Nakagomi Yasue Tanaka Nami Nakagomi Tomohiro Matsuyama Shinichi Yoshimura Ischemic stroke caused by cerebral artery occlusion induces neurological deficits because of cell damage or death in the central...
Wed Sep 02, 2020 03:00
IJNS, Vol. 6, Pages 72: Current Practices for U.S. Newborn Screening of Pompe Disease and MPSI International Journal of Neonatal Screening doi: 10.3390/ijns6030072 Authors: Elizabeth G. Ames Rachel Fisher Mary Kleyn Ayesha Ahmad Two lysosomal storage disorders (LSDs), Pompe disease and Mucopolysaccharidosis type I (MPSI) were added to the Recommended Uniform Screening Panel (RUSP) for newborn screening (NBS) in 2015 and 2016, respectively. These conditions are being screened...
Wed Sep 02, 2020 03:00
JCM, Vol. 9, Pages 2849: Postoperative Telephone-Based Questionnaire on Quality of Life after Robotic-Assisted Laparoscopic Hysterectomy versus Conventional Total Laparoscopic Hysterectomy Journal of Clinical Medicine doi: 10.3390/jcm9092849 Authors: Mohamed Elessawy Sarah Schneekloth Veronika Günther Nicolai Maass Liselotte Mettler Ibrahim Alkatout Aim: The objective of the study was to evaluate the benefits of robotic-surgery for hysterectomy compared to conventional...
Wed Sep 02, 2020 03:00
JCM, Vol. 9, Pages 2847: Clinical Significance of Timing of Intubation in Critically Ill Patients with COVID-19: A Multi-Center Retrospective Study Journal of Clinical Medicine doi: 10.3390/jcm9092847 Authors: Yong Hoon Lee Keum-Ju Choi Sun Ha Choi Shin Yup Lee Kyung Chan Kim Eun Jin Kim Jaehee Lee The effect of intubation timing on the prognosis of critically ill patients with coronavirus 2019 (COVID-19) is not yet well understood. We investigated whether early intubation...
Wed Sep 02, 2020 03:00
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