Lung cancer is the most common cancer diagnosis (about 1.8 million new cases per year), and the leading cause of cancer death (1.59 million deaths per year) in the world [1]. Currently, small-cell lung cancer (SCLC) accounts for 13% of all lung cancers, and more than 2/3 of the patients present with metastatic disease. As opposed to NSCLC, patients often have a bulky mediastinal disease at presentation, frequently with involvement of bilateral mediastinal lymph nodes. After staging procedures, SCLC...
Sun Jul 12, 2020 03:00
We appreciate the opportunity to review the response of Dr. Cellini and colleagues to our manuscript “Recommendations on the use of radiation therapy in managing patients with gastrointestinal malignancies in the era of COVID-19.”1 We agree with Dr. Cellini that preoperative chemoradiation, and not preoperative chemotherapy, is and should remain the standard of care in the management of esophageal cancer, of either histology. As Dr. Cellini and colleagues point out, while there are no randomized...
Sun Jul 12, 2020 03:00
Dear Editor, we read with interest the paper of Tchelebi et al. addressing the choices for optimizing clinical indication and resources along the current pandemic scenario [1]. In regard of locally advanced esophageal cancer they suggest to apply preoperative concurrent radiochemotherapy (pRTCT), being the standard option; it should be given using the shortest fractionation scheme possible. Finally, induction chemotherapy is mentioned as alternative to delay the initiation of daily radiotherapy,...
Sun Jul 12, 2020 03:00
The COVID-19 pandemic has dramatically impacted surgical capacity, radiotherapy and chemotherapy delivery worldwide. Contributing factors include the importance of social distancing to reduce viral transmission, the recognition that cancer patients have a higher risk of severe events compared to non-cancer patients [1], and resource limitations of the cancer centre with limited personal protective equipment (PPE), staffing shortages due to illness and redeployment. Recommendations have been made...
Sun Jul 12, 2020 03:00
Publication date: Available online 12 July 2020Source: Journal of ProteomicsAuthor(s): Julien Faugere, Duarte Gouveia, Sophie Ayciriex, Arnaud Chaumot, Christine Almunia, Adeline François, Jean Armengaud, Jérôme Lemoine, Olivier Geffard, Davide Degli-Esposti, Arnaud Salvador
Mon Jul 13, 2020 21:00
Publication date: Available online 13 July 2020Source: Human PathologyAuthor(s): Yajuan J. Liu, Cigdem Ussakli, Tatjana Antic, Yuhua Liu, Yu Wu, Lawrence True, Maria S. Tretiakova
Mon Jul 13, 2020 20:43
Publication date: Available online 12 July 2020Source: Human PathologyAuthor(s): Björn Konukiewitz, Matthias von Hornstein, Moritz Jesinghaus, Katja Steiger, Wilko Weichert, Sönke Detlefsen, Atsuko Kasajima, Günter Klöppel
Mon Jul 13, 2020 20:43
Step aside, skeletons -- a new world of biochemical ''signatures'' found in all kinds of ancient fossils is revealing itself to paleontologists, providing a new avenue for insights into major evolutionary questions.
Mon Jul 13, 2020 19:00
Publication date: September 2020Source: European Journal of Cancer, Volume 136Author(s): Deepesh P. Lad
Mon Jul 13, 2020 20:09
Background: The Clinical COPD Questionnaire (CCQ) has been suggested by the Global Initiative of Chronic Obstructive Lung Disease (GOLD) as a comprehensive symptom measurement tool, which helps to classify patients in order to direct pharmacological treatment. Therefore, it is essential to understand its determinants. Objectives: To identify the determinants of the overall CCQ score and scores of its 3 subdomains among chronic obstructive pulmonary disease (COPD) patients from China. Methods: A total...
Mon Jul 13, 2020 12:10
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Nature Communications, Published online: 13 July 2020; doi:10.1038/s41467-020-17209-1Reliable, multiplexed gene editing to uncover synergies between targets remains challenging. Here, the authors engineer AsCas12a and the crRNA to improve double knockout for synthetic sick/lethal interaction genetic screening.
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Nature Communications, Published online: 13 July 2020; doi:10.1038/s41467-020-17270-wThe vCA1-BA projection is enriched in shock responsive neurons, which are necessary for fear memory encoding and become correlated with a network of neurons during retrieval. Here the authors show that the magnitude of vCA1 correlated activity is proportional to memory strength and requires the shock response during encoding.
Mon Jul 13, 2020 03:00
Nature Communications, Published online: 13 July 2020; doi:10.1038/s41467-020-17300-7It is unclear whether 2D metal dichalcogenides (TMD) alone can cause ferroptotic cell death. Here, the authors show TMD nanosheets induced ferroptosis in mammalian cell lines and in a mouse model after aspiration of TMD materials into lungs, causing ferroptotic cell death.
Mon Jul 13, 2020 03:00
Nature Communications, Published online: 13 July 2020; doi:10.1038/s41467-020-17113-8Mice are able to discriminate colors, at least in the upper visual field. Here, the authors provide a comprehensive characterization of retinal circuits underlying this behavior.
Mon Jul 13, 2020 03:00
Nature Communications, Published online: 13 July 2020; doi:10.1038/s41467-020-17212-6Melanosomes traffic along F-actin in melanocytes. Here, the authors show that Rab27a coordinates SPIRE/FMN actin assembly and MyoVa motor proteins to generate a cell-wide actin/myosin network that links melanosomes and allows the collective activity of these force generators to drive their traffic.
Mon Jul 13, 2020 03:00
Nature Communications, Published online: 13 July 2020; doi:10.1038/s41467-020-17255-9Explicit self-reflection is unreliable for measuring thoughts. Here, the authors use brain data to implicitly pinpoint transitions between thoughts and find thought turnover to be reliably predicted by narrative events during movie-viewing, as well as by greater trait neuroticism at rest.
Mon Jul 13, 2020 03:00
Nature Communications, Published online: 13 July 2020; doi:10.1038/s41467-020-17220-6Catalytic selectivity during carbon dioxide electroreduction can be tuned by using geometric copper-based catalysts. Here, the authors use liquid cell transmission electron microscopy to study the in situ synthesis and morphological evolution Cu2O cubes under carbon dioxide electroreduction conditions.
Mon Jul 13, 2020 03:00
Nature Communications, Published online: 13 July 2020; doi:10.1038/s41467-020-17274-6Multiple quantum critical behaviors exist in the heavy fermion material CeRhIn5, but their interrelation is less studied. Here, Helm et al. investigate the interrelation of two quantum critical points and other relevant orders, revealing a strongly non-mean-field-like phase diagram.
Mon Jul 13, 2020 03:00
Nature Communications, Published online: 13 July 2020; doi:10.1038/s41467-020-17171-yThe global biodiversity decline might conceal complex local and group-specific trends. Here the authors report a quantitative synthesis of longterm biodiversity trends across Europe, showing how, despite overall increase in biodiversity metric and stability in abundance, trends differ between regions, ecosystem types, and taxa.
Mon Jul 13, 2020 03:00
Publication date: Available online 12 July 2020Source: The Journal of Prosthetic DentistryAuthor(s): Xavier Lepe, Kerry R. Streiff, Glen H. Johnson
Mon Jul 13, 2020 18:57
Publication date: Available online 12 July 2020Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Frederik Peters, Thea Kreutzburg, Henrik C. Rieß, Franziska Heidemann, Ursula Marschall, Helmut L'Hoest, Eike S. Debus, Art Sedrakyan, Christian-Alexander Behrendt
Mon Jul 13, 2020 18:40
Publication date: Available online 13 July 2020Source: Archives of Physical Medicine and RehabilitationAuthor(s): Marcel W. Post, Jan D. Reinhardt, Mercè Avellanet, Reuben Escorpizo, Julia P. Engkasan, Urban Schwegler, InSCI, Annelie Schedin Leiulfsrud
Mon Jul 13, 2020 18:17
Publication date: Available online 12 July 2020Source: Archives of Physical Medicine and RehabilitationAuthor(s): Nicola Marotta, Andrea Demeco, Cinzia Marinaro, Lucrezia Moggio, Ilaria Pino, Marianna Barletta, Annalisa Petraroli, Antonio Ammendolia
Mon Jul 13, 2020 18:17
Publication date: Available online 12 July 2020Source: Behavioural Brain ResearchAuthor(s): Alicia M.P. Warnecke, Moon S. Kang, Michael W. Jakowec, Daryl L. Davies
Mon Jul 13, 2020 17:57
Publication date: Available online 13 July 2020Source: Pathology - Research and PracticeAuthor(s): Hyun Ji Son, Ha Yoon Mo, Nam Jin Yoo, Sug Hyung Lee
Mon Jul 13, 2020 17:50
Publication date: Available online 13 July 2020Source: Pathology - Research and PracticeAuthor(s): Jamal Halajzadeh, Parisa Maleki Dana, Zatollah Asemi, Mohammad Ali Mansournia, Bahman Yousefi
Mon Jul 13, 2020 17:50
Publication date: Available online 12 July 2020Source: Pathology - Research and PracticeAuthor(s): Michel P.J. Teuben, Martijn Hofman, Johannes Greven, Alba Shehu, Henrik Teuber, Roman Pfeifer, Hans-Christoph Pape, Frank Hildebrand
Mon Jul 13, 2020 17:50
Publication date: Available online 12 July 2020Source: Pathology - Research and PracticeAuthor(s): Milena Vuletic, Snezana Jancic, Sanja Milenkovic, Marinko Paunovic, Biljana Milicic, Nina Jancic, Biljana Perunicic, Zivana Slovic
Mon Jul 13, 2020 17:50
Abstract If a patient’s cancer progresses while undergoing targeted therapy, a re-biopsy is not mandatory. But when evaluating the benefits and risks on a case-by-case basis (transformation to small cell, assessing for a clinical trial), physicians should inform patients about the possible need for a re-biopsy (5). This was a retrospective and multicentre study. A total of 644 patients with lung adenocarcinoma were reviewed, 625 of whom were ruled eligible. From them, 399 were...
Mon Jul 13, 2020 03:00
Abstract We tested the prognostic relevance of metabolic parameters and their relative changes in patients with metastatic colorectal cancer (mCRC) treated with monoclonal antibody and chemotherapy. SUVmax (standardized uptake volume), SAM (standardized added metabolic activity) and TLG (total lesion glycolysis) are assessed with 18F-fluorodeoxyglucosepositron emission tomography and computed tomography (FDG-PET/CT) to evaluate total metabolic activity of malignant processes....
Mon Jul 13, 2020 03:00
Abstract There is no evidence that prolonged pre diagnostic symptomatic intervals (PSI) increases the risk of death in pediatric brain tumors. When investigating the role of time previous research had not controlled for confounding variables or measured the pretreatment interval (PTI). We use the term global delay interval (GDI) to describe the sum of PSI and PTI. The aim of this research was to evaluate whether there was a decrease in the probability of survival in children with...
Mon Jul 13, 2020 03:00
Natural products are used as alternative drugs in traditional medicine to treat infection and inflammation and relieve pain. Heartwood of Cassia garettiana Craib has been investigated as an ingredient in Thai traditional medicine for anti-HIV protease, but there is no report on its antibacterial and anti-inflammatory activities. The objectives of this study were to investigate the anti-inflammatory and antibacterial activities, time-kill profile, and main active constituents of an ethanolic extract...
Mon Jul 13, 2020 11:50
Deep borehole heat exchanger (DBHE) technology does not depend on the existence of hot water reservoir and can be used in various regions. However, the heat extraction from DBHE can hardly be improved due to poor thermal conductivity of rocks. Here, a single-well enhanced geothermal system (SWEGS) is proposed, which has a larger heat-exchange area of artificial reservoir created by fracturing hydrothermal technology. We find that, due to heat convection between rocks and fluid, the extracted thermal...
Mon Jul 13, 2020 11:50
Background and Objective. Management of immature permanent teeth exhibiting necrotic pulp is clinically challenging. An appropriate diagnosis, case selection, and good management ensure good outcomes. The objective of this review reviews all up-to-date data in regard to endodontic regeneration therapy in the management of immature permanent teeth with necrotic pulp and which conducts are most used and appropriate for this procedure in human and animal investigations. Materials and Methods. The electronic...
Mon Jul 13, 2020 11:35
Abstract Purpose This experimental sepsis model created with Escherichia coli aimed to investigate the histopathological effects of two different doses of ozone combined with antibiotherapy on lung tissue. Methods Rats were divided into 5 groups. Then sepsis was induced intraperitoneally in the first 4 groups. The 1st group was treated with cefepime, the 2nd and 3rd groups were treated with cefepime combined with ozone at a dose of 0.6 mg/kg and 1.1 mg/kg. Lung tissue sections were stained with...
Mon Jul 13, 2020 17:09
Abstract Purpose To determine by histomorphometric analysis whether CO2 pneumoperitoneum interferes with collagen deposition in surgical wounds in the aponeurosis of rats. Methods This experiment involved 80 male Wistar rats, randomly allocated into four groups according to pneumoperitoneum period (PRE: 30 min preoperatively; POST: 30 min postoperatively; PP: 30 min pre- and postoperatively; C: control group). CO2 pneumoperitoneum was insufflated to 5 mmHg of pressure. A laparotomy was performed;...
Mon Jul 13, 2020 17:09
Abstract Purpose To develop a 3D anatomical model for teaching canine epidural anesthesia (3DMEA) and to assess its efficacy for teaching and learning prior to the use of live animals. Methods The creation of 3DMEA was based on 3D optical scanning and 3D printing of canine bone pieces of the fifth to the seventh lumbar vertebrae, sacrum and pelvis. A total of 20 male dogs were scheduled for castration. 20 veterinary students watched a video showing epidural anesthesia in dogs before the clinical...
Mon Jul 13, 2020 17:09
Background Bacterial odontogenic sinusitis (ODS) is distinct from other forms of rhinosinusitis. Diagnosing ODS can be challenging because of nonspecific clinical presentations and underrepresentation in the literature. The purpose of this study was to compare maxillary sinus bacterial cultures between patients with ODS and chronic rhinosinusitis (CRS), to determine whether certain bacteria are associated with ODS. Methods This was a retrospective case‐control study of 276 consecutive patients...
Sun Jul 12, 2020 21:00
Publication date: Available online 12 July 2020Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Hasan Onur Şimsek, Ozlem Kocaturk, Umut Demetoglu, Burcu Groytrak
Mon Jul 13, 2020 16:21
Abstract Purpose The aim of the present study was to evaluate the four methods for bilateral sagittal osteotomy fixation. Methods In this study, 56 replicas of whole mandibles made of rigid polyurethane were used. After simulation of major advancement (11 mm) with clockwise rotation of the mandible (6o) in relation to the occlusal plane, the bone segments...
Mon Jul 13, 2020 03:00
Abstract Objectives The purpose of this study was to examine changes in lateral pterygoid muscle and temporomandibular joint (TMJ) disc position in classes II and III patients, before and after bi-maxillary surgery. Materials and methods The subjects were comprised of 48 patients (96 sides), 23 of whom were diagnosed as class II and 25 as class III...
Mon Jul 13, 2020 03:00
Summary Fusions involving neurotrophic tyrosine receptor kinase (NTRK) are known drivers of oncogenesis and also occur in melanoma, although very rarely. A particularly high incidence of NTRK gene fusions is reported in infantile fibrosarcoma (> 90 %) or the secretory type of breast cancer (> 90 %). Recently, larotrectinib (a tropomyosin receptor kinase [TRK] inhibitor) was approved, and we wondered whether TRK inhibitors might also be helpful for melanoma patients. We therefore screened...
Sun Jul 12, 2020 20:46
Sun Jul 12, 2020 20:46
Summary Background The melanin fluorescence of skin lesions is measurable with two‐photon excitation, a process termed dermatofluoroscopy, which has shown a shift from the green spectra in benign melanocytic lesions to the red spectra in melanoma. This study addressed the question as to which kind of pigmented lesions can be correctly diagnosed as melanin‐bearing malignant tumors. Methods 476 pigmented lesions including 101 cutaneous melanomas were analyzed with dermatofluoroscopy, measuring...
Sun Jul 12, 2020 20:45
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