Objective: To review insights gained from a 21-year experience with gentamicin-induced vestibulotoxicity including differences in vestibulotoxicity between single daily dosing (SDD) and multiple daily dosing (MDD) regimens. Study Design: Retrospective case series. Setting: Tertiary care center. Patients: Patients with gentamicin vestibulotoxicity referred to the Hertz Multidisciplinary Neurotology Clinic between January 1993 and September 2014. Intervention: None. Main Outcome...
Mon Jul 13, 2020 23:52
Background: The perimodiolar CI532 Slim Modiolar electrode has been designed to bring the electrode contacts close to auditory nerve while reducing cochlear trauma during its insertion. It is currently unknown to what extent the electrode position and electrophysiological outcomes of the Slim Modiolar electrode differ from other perimodiolar electrodes. Objectives: The objective was to compare the electrode position and electrophysiological outcomes between the CI532 Slim Modiolar and CI512...
Mon Jul 13, 2020 23:52
Objective: Given the heterogeneity of papers about electrocochleography (ECochG) and cochlear implantation (CI) and the absence of a systematic review in the current literature, the aim of this work was to analyze the uses of ECochG in the different stages of CI. Data Sources: A search of PubMed from inception to December 8, 2019, with cross-references, was executed. Keywords were: “Cochlear Implant” OR “Cochlear Implantation” AND “Electrocochleography” OR “ECochG.” The main eligibility criteria...
Mon Jul 13, 2020 23:52
No abstract available
Mon Jul 13, 2020 23:52
No abstract available
Mon Jul 13, 2020 23:52
Hypothesis: Nitinol is a suitable material for passive middle ear prosthesis. Background: In modern ear microsurgery, the restitution of hearing is tremendously important. In passive ossicular reconstruction, rigid alloplastic materials are widespread in use. However, rigid prostheses fail to adapt to atmospheric pressure changes. We describe the use of the super-elastic material nitinol in passive ossicular reconstruction to overcome this limitation. Methods: Together with an industrial...
Mon Jul 13, 2020 23:52
Objective: To evaluate the treatment efficacy of transcutaneous electrical nerve stimulation (TENS) in patients with tinnitus. Data Sources: PubMed, Scopus, Web of Science, and Cochrane Library were searched for the following concepts: “Transcutaneous Electric Nerve Stimulation” and “Tinnitus.” Study Selection: Inclusion: 1) double- or single-blinded randomized controlled trials; 2) double- or single-blinded randomized comparison trials; 3) prospective or retrospective observational...
Mon Jul 13, 2020 23:52
Hypothesis and Background: Hearing loss leads to synaptic changes in auditory neurons and their networks, and functions as a consequence of the interplay between genes and proteins. However, cellular and molecular mechanisms leading to deafness-induced plasticity in the auditory cortex (AC) remain unclear. Here, we examined the changes in gene expression and key signaling pathways that regulate differentially expressed genes (DEGs) in the AC following auditory deafferentation using RNA-sequencing...
Mon Jul 13, 2020 23:52
Hypothesis: An augmented reality (AR) platform using a head mounted display (HMD) can successfully display and register virtual computerized tomography (CT) data to corresponding real world anatomy using fiducial markers. Background: AR is a growing field in surgical planning, and has been used by this group to aide in orthopedic surgery applications. Intraoperative AR registration of preoperative CT images could improve identification of critical anatomical structures during lateral skull...
Mon Jul 13, 2020 23:52
Objective: After tympanoplasty, it is often challenging to differentiate between different causes of a remaining air bone gap (ABG). Optical coherence tomography (OCT) offers a new approach for combined morphologic and functional measurements of the tympanic membrane and adjacent parts of the middle ear. Thus, it provides valuable diagnostic information in patients with a reduced sound transfer after middle ear surgery. Patient and intervention: A patient with history of tympanoplasty and...
Mon Jul 13, 2020 23:52
Objective: The aims of this multicenter study were to prospectively evaluate the prevalence of dead regions (DRs) in sudden sensorineural hearing loss (SSNHL) and compare the clinical characteristics and hearing outcomes of SSNHL according to the presence of DRs. Study Design: Prospective study. Setting: Multicenter study. Patients and Methods: The threshold-equalizing noise (TEN) test was prospectively performed on a total of 130 patients diagnosed with SSNHL. All patients received...
Mon Jul 13, 2020 23:52
Objective: To evaluate the effectiveness of a 60/60 referral guideline for identifying patients who should be referred for a cochlear implant candidacy evaluation (CICE), which states patients should be referred if they demonstrate a best ear unaided monosyllabic word score less than or equal to 60% correct and if they demonstrate an unaided pure-tone average in their better ear that is greater than or equal to 60 dB HL. Study Design: Retrospective review of data from adults who participated...
Mon Jul 13, 2020 23:52
Objective: To examine the importance of video head impulse test parameter for recovery of symptoms in acute vestibular neuritis (AVN). Study Design: Prospective study. Setting: Tertiary referral hospital. Patients/Interventions: Twenty-seven patients with AVN were enrolled. We divided patients into two groups according to both dizziness handicap inventory (DHI) score and visual analog scale (VAS) at 6 months: Group F (symptoms free), DHI = 0 and VAS = 0; Group R (symptoms residual),...
Mon Jul 13, 2020 23:52
Objective(s): To evaluate 2-year audiological and clinical outcomes of a transcutaneous implant for bone conduction hearing of a previously published 6-month evaluation. Design: Fifty-four unilaterally implanted adult patients with conductive or mild mixed hearing loss or single-sided sensorineural deafness were included in this prospective multicenter study. Follow-up visits were scheduled post-surgery at 10 days; 4, 6, and 12 weeks; 6, 12, and 24 months. Main outcomes were audiological...
Mon Jul 13, 2020 23:52
Objectives: This article discusses the diagnosis, imaging workup, and management of a rare cause of pulsatile tinnitus: intraparotid arteriovenous malformation. Patient: A single patient with a superficial temporal arteriovenous malformation diagnosed by carotid duplex causing pulsatile tinnitus that failed initial surgical management. Repeat imaging failed to identify a cause for the persistent tinnitus. Intervention: Reoperation with a parotid approach based on physical exam findings. ...
Mon Jul 13, 2020 23:52
Objective: To confirm the association between chronic kidney disease and sensorineural hearing loss in non-dialysis non-diabetic patients and to establish the audiological profile of these patients indicating the possible location of the auditory damage. Study Design: Cross-sectional study. Setting: Tertiary referral center. Patients: Patients between 18 and 60 years old with chronic kidney disease, without diabetes mellitus and without personal history of otology disease, were...
Mon Jul 13, 2020 23:52
Hypothesis: Whereas autophagy has been linked to various human diseases, whether it also plays a role in cholesteatoma is virtually unknown. This study aimed to investigate the activity and regulation of autophagy in cholesteatoma. Background: The treatment of middle ear cholesteatoma has been challenging due to an insufficient understanding of the underlying disease mechanism. Methods: Expression of microtubule-associated protein 1A/1B-light chain 3 (LC3), the autophagy protein marker,...
Mon Jul 13, 2020 23:52
Objective: To review outcomes of stapes surgery in patients with concurrent otosclerosis and superior semicircular canal dehiscence. Study Design: Retrospective case series. Setting: Tertiary referral center. Patients: Patients with concurrent otosclerosis and superior canal dehiscence, confirmed by computed tomography (CT) imaging. Intervention(s): Stapes surgery for conductive hearing loss. Main Outcome Measure(s): Postoperative air-bone gap (ABG), as well as the number...
Mon Jul 13, 2020 23:52
No abstract available
Mon Jul 13, 2020 23:52
Objective: To determine the incidence of hearing loss (HL) as well as differences in wages and labor force participation rates between individuals with and without HL. Study Design: Retrospective ecological study. Patients: 1% of the US population including individuals with and without HL from the public use micro data sample (PUMS) of the 2011 to 2016 American Community Survey (ACS) was analyzed. Main Outcome Measure: ACS census data on individual age, self-reported hearing loss,...
Mon Jul 13, 2020 23:52
Objectives: In patients with chronic middle ear disease, especially after revision surgery for ventilation problems and mixed hearing loss, active middle ear implants may provide an alternative treatment option. The fully implantable active middle-ear implant (FI-AMEI) is designed for implantation in a ventilated mastoid with an intact posterior canal wall. Until now, there have been no reports on audiometric results after implantation of a FI-AMEI in a fat-obliterated cavity after subtotal petrosectomy...
Mon Jul 13, 2020 23:52
Objective: To evaluate the treatment outcomes of nimodipine and steroid combination therapy for idiopathic sudden sensorineural hearing loss (ISSNHL). Study Design: Retrospective case review. Setting: Tertiary referral center. Patients: Seventy-eight patients who were diagnosed with ISSNHL were divided into two group based on the treatment strategies used: steroid+nimodipine (SN, n = 36) and steroid only (SO, n = 42) groups. Based on the level of hearing loss before treatment, subgroup...
Mon Jul 13, 2020 23:52
Objective: Previous studies reported that balance deficits in pitch (sagittal) and roll (lateral) planes during stance and gait after onset of an acute unilateral peripheral vestibular deficit (aUPVD) due to vestibular neuritis are weakly correlated with deficits in commonly explored lateral canal vestibular ocular reflex (VOR) responses. Theoretically, stronger correlations with roll and pitch balance deficits could be expected for vertical canal VOR responses. Therefore, we investigated these...
Mon Jul 13, 2020 23:52
Objectives: Sudden sensorineural hearing loss (SSNHL) may occur in post-irradiated nasopharyngeal carcinoma (NPC) survivors with a rare rate. This study was conducted to evaluate the clinical characteristics and prognosis of this population. Study Design: Retrospective cohort study. Setting: Tertiary otology referral center. Patients: Five hundred ninety nine SSNHL patients were recruited between January 2010 and January 2019. Patients were divided into two groups: NPC group (n = 24)...
Mon Jul 13, 2020 23:52
Objective: Conventional bone conduction hearing aid solutions often require a cumbersome retention system such as a headband or cap. This study aims to determine if a novel, nonsurgical bone conduction aid utilizing an adhesive attachment over the mastoid is equivalent to the conventional bone conduction hearing aid (BCHA) for the management of conductive hearing loss. Study Design: Prospective, single-subject randomized, crossover trial. Setting: Tertiary referral center. Patients:...
Mon Jul 13, 2020 23:52
Objective: To evaluate opioid prescribing patterns following cochlear implantation (CI) and assess factors associated with recurrent opioid use. Study Design: Retrospective cohort study. Setting: National pharmaceutical database recording opioid fulfillment (Truven Health Marketscan Commercial Claims and Encounters and Medicare Claims and Encounters database) Participants: CI recipients who filled opioid prescriptions between January 2011 and December 2016. All patients had no previous...
Mon Jul 13, 2020 23:52
Objective: To determine if symptoms regarding timing and triggers of dizziness are useful for categorizing patients with dizziness, and to evaluate how patient-reported symptoms predict vestibular asymmetry, postural sway, and vestibular diagnoses. Study Design: Retrospective chart review. Setting: Tertiary referral center. Patients: Patients referred for suspected vestibular disease. Interventions: Patients completed a symptom questionnaire before laboratory testing with static...
Mon Jul 13, 2020 23:52
Hypotheses: Adult cochlear implant (CI) outcomes depend on demographic, sensory, and cognitive factors. However, these factors have not been examined together comprehensively for relations to different outcome types, such as speech recognition versus quality of life (QOL). Three hypotheses were tested: 1) speech recognition will be explained most strongly by sensory factors, whereas QOL will be explained more strongly by cognitive factors. 2) Different speech recognition outcome domains (sentences...
Mon Jul 13, 2020 23:52
Objective: We describe three rare cases of spontaneous intracranial hypotension (SIH) presenting with symptoms of endolymphatic hydrops (EH) and perform a literature review to bring attention to a rare link between SIH and EH. Patient: A 59-year-old female presented with postural headache, aural fullness, vertigo, hearing loss, and abnormal electrocochleography after being diagnosed with SIH by magnetic resonance imaging. The site of cerebrospinal fluid leak was identified in this individual....
Mon Jul 13, 2020 23:52
Objectives: To examine the effect of aging on electrically evoked compound action potential (eCAP) growth functions and their relationship with speech recognition in noise in cochlear implant (CI) users. Background: Aging typically leads to difficulty understanding speech in background noise. Previous research has explored cognitive and central auditory mechanisms contributing to these age-related changes. However, it is likely that the peripheral auditory system may also play a role. One...
Mon Jul 13, 2020 23:52
Objective: This study aimed to describe our experience with the retrolabyrinthine or infralabyrinthine approach in acoustic neuroma surgery, and to discuss its advantages, limitations, complications, and the outcomes of hearing and facial function preservation. Study Design: This study was a retrospective analysis of all acoustic neuroma cases, operated with a retrolabyrinthine approach in our hospital. Setting: This study was conducted at a tertiary university hospital. Patients:...
Mon Jul 13, 2020 23:52
Objectives: The aim of this study was to determine whether the dexamethasone-eluting electrode (DEXEL) has a protective anti-inflammatory effect in a normal hearing implanted cochlea, as well as its performance and safety. Design: Ten healthy and normal hearing cynomolgus macaques (Mf) were divided into two cohorts: DEXEL group (DG) (CONCERTO CI device containing a DEXEL) and conventional CI group (CG) (unmodified CONCERTO CI device). The electrode was inserted into the scala tympani via...
Mon Jul 13, 2020 23:52
Objectives: To investigate novel variants in hearing loss genes and clinical factors affecting audiometric outcomes of cochlear implant (CI) patients. Background: Approximately 50% of hearing loss has a genetic etiology, with certain genetic variants more prevalent in specific ethnic groups. Different variants and some clinical variables including inner ear malformations result in different prognoses or clinical outcomes after CI. Methods: Medical and genetic testing records of pediatric...
Mon Jul 13, 2020 23:52
Objective: To determine factors associated with infection, management, and resultant outcomes following pediatric cochlear implantation. Study Design: Retrospective cohort study with nested case series. Setting: Tertiary academic medical center. Patients: Children who underwent either unilateral or bilateral cochlear implantation between June 2011 and September 2016 and were under the age of 18 at the time of surgery. Intervention(s): Subjects were compared based on age, cochlea...
Mon Jul 13, 2020 23:52
Hypothesis: Circumferential electrocautery injury of the rat external auditory canal (EAC) can induce a reproducible animal model of acquired stenosis. Background: Acquired EAC stenosis may occur as a result of chronic inflammation or trauma to the EAC skin and is characterized by narrowing of the EAC, retention of debris, and hearing loss. Treatment is surgery but it is often complicated by restenosis. A reliable and inexpensive animal model of EAC stenosis has not been described. There...
Mon Jul 13, 2020 23:52
Objective: To investigate the disturbance induced in the cochlea during cochleostomy using conventional drill and a hand guided robotic drill. Study Design: The study is based on experimental measurements using the Laser Doppler Vibrometer during the drilling processes converted to Sound Pressure Levels (SPL) for comparison. Setting: The study is based on experimental results of three sets of cochleostomies on human cadaver heads. Main Outcome Measure(s): Robotic drilling, in comparison...
Mon Jul 13, 2020 23:52
Objective: To mark the centenary of Adam Politzer's death by investigating and celebrating the legacy he left to otology. Politzer is arguably one of the greatest otologists of the last 200 years and his textbook on otological history is undoubtedly the seminal work on the subject. The aim of this paper is twofold. Not only do the authors hope to find out if he is still remembered by otolaryngologists, but also what has been the greatest legacy which he has bequeathed to them. Methodology: ...
Mon Jul 13, 2020 23:52
Objective: To discuss the natural history and management of pneumolabyrinth, with particular attention to illustrative cases where hearing improved after a fluid-filled vestibule was restored. Patients: Adults at two academic medical centers with documented pneumolabyrinth on computed tomography (CT) imaging. Intervention: Middle ear surgery or observation. Main Outcome Measures: Cochlear and vestibular symptoms are reported. Inner ear function was documented with audiometry and...
Mon Jul 13, 2020 23:52
Cochlear implantation in patients with intracochlear schwannomas has been reported anecdotally in case reports or small case series (1–5). The applied techniques have varied considerably ranging from extended cochleostomy (2–4), “push-through” and ”pull-through” techniques (3,4), partial and subtotal cochleoectomy (4) to cochlear implant insertion through the tumor (5). We here illustrate (see Video, Supplemental Digital Content 1, http://links.lww.com/MAO/A999) our improved surgical technique of...
Mon Jul 13, 2020 23:52
Objective: Sound processor loading times after bone-anchored hearing implant (BAHI) surgery have gradually decreased over time. This study assessed patient preferences in loading time. Study Design: Prospective patient questionnaire study. Setting: Tertiary referral center. Patients: Patients indicated for BAHI surgery received two questionnaires preoperatively: the validated Glasgow Health Status Inventory (GHSI) and a nonvalidated questionnaire that assessed patient preference...
Mon Jul 13, 2020 23:52
Hypothesis: Before modern imaging was introduced, revision surgery was the only way to evaluate possible reasons for inadequate improvement in hearing after ossicular replacement during reconstructive middle ear surgery. Background: The aim of this study was to evaluate freely navigable virtual tympanoscopy using different computed tomographic modalities. We compared cone-beam computed tomography (CBCT), flat panel computed tomography (FPCT), and conventional computed tomography in helical...
Mon Jul 13, 2020 23:52
Objective: The risk of sudden sensorineural hearing loss (SSNHL) was suggested to be increased in chronic otitis media patients. This study expanded previous findings by using pediatric patients with recurrent otitis media. Study Design: A nested case-control study. Setting: Participants in the Korean National Health Insurance Service-National Sample Cohort that were less than 15 years old from 2002 to 2004 were included. Patients: Overall, 24,226 patients with ≥ 5 instances of...
Mon Jul 13, 2020 23:52
Objective: The coupling efficiency of a semi-implantable active middle ear implant with an electromagnetically driven floating mass transducer coupled to a middle ear ossicle or the round window can only be quantified postoperatively in cooperative patients by measuring behavioral vibroplasty in situ thresholds in comparison with bone conduction thresholds. The objective of the study was to develop a method to objectively determine the vibroplasty in situ thresholds by determining calibration...
Mon Jul 13, 2020 23:52
Objectives: To evaluate the efficacy of 2.5% sodium bicarbonate and docusate sodium in patients with complete occlusion of the ear canal from impacted cerumen. Study Design: Randomized controlled trial. Method: We enrolled patients with unilateral complete cerumen occlusion of the ear canal that was unable to be removed using suction. Either 2.5% sodium bicarbonate or docusate sodium was applied and allowed to sit for 15 minutes. The ear canal was then cleaned under a microscope for...
Mon Jul 13, 2020 23:52
Objective: Generation of pilot data for planning of prospective BET-studies for treatment of dilatory Eustachian tube (ET) dysfunction in children. Study Design: Retrospective multicenter analysis. Setting: Nine ENT departments at tertiary care teaching hospitals. Patients: 4–12-year-old children with chronic otitis media with effusion (COME) for more than 3 months or more than 3 episodes of acute otitis media during the last year, having failed standard surgical therapy at least...
Mon Jul 13, 2020 23:52
Objective: Characterize relations between vitamin D deficiency (VDD), hypocalcemia, and hearing loss (HL) in children. Study Design: Retrospective review. Setting: Tertiary referral hospital. Patients: Children in the Audiological and Genetic Database with a diagnosis of VDD, rickets, or osteomalacia. Intervention: None. Main Outcome Measures: Prevalence, type, severity (4-tone pure-tone average, PTA), and progression of HL. HL was defined as greater than 15 dB HL at any...
Mon Jul 13, 2020 23:52
Objective: Vestibular deficit patients have an increased fall risk and fear of falling. Postural threat, known to increase balance-related fear and anxiety, influences vestibular gains during quiet standing in young healthy adults. The current study examined whether there is a similar relationship for peripheral unilateral vestibular loss (UVL) patients in comparison to age-matched healthy controls (HC). Setting: University laboratory. Study Design: Prospective laboratory study. Patients...
Mon Jul 13, 2020 23:52
Objective: To evaluate auditory manifestations in children born to mothers who had exanthema during pregnancy, suspected to have been exposed to the Zika virus (ZIKV). Study Design: Prospective observational. Setting: Tertiary referral center. Patients: Children born in Rio de Janeiro, Brazil, between April 2016 and September 2017, who were referred for newborn hearing screening (NHS). Intervention: The NHS was performed by the automated brainstem auditory-evoked potential...
Mon Jul 13, 2020 23:52
Hypothesis: Bone-conducted vibration (BCV) at 100 Hz causes endolymph displacement at hair cell stereocilia in semicircular canal (SCC) ducts of the intact bony labyrinth resulting in activation of irregularly discharging afferent neurons. Background: Suprathreshold 100 Hz BCV is employed in the clinic to evoke skull vibration-induced nystagmus, an indicator for peripheral vestibular asymmetry. Recently, this stimulus has also been used in vestibular-evoked myogenic potentials, a selective...
Mon Jul 13, 2020 23:52
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