Antibiotics, Vol. 9, Pages 406: The Antimicrobial Activity of Cannabinoids Antibiotics doi: 10.3390/antibiotics9070406 Authors: Karas Wong Paulin Mazeh Hussein Li Velkov A post-antibiotic world is fast becoming a reality, given the rapid emergence of pathogens that are resistant to current drugs. Therefore, there is an urgent need to discover new classes of potent antimicrobial agents with novel modes of action. Cannabis sativa is an herbaceous plant that has...
Mon Jul 13, 2020 03:00
Antibiotics, Vol. 9, Pages 405: Functional Analysis of the Acinetobacter baumannii XerC and XerD Site-Specific Recombinases: Potential Role in Dissemination of Resistance Genes Antibiotics doi: 10.3390/antibiotics9070405 Authors: David L. Lin German M. Traglia Rachel Baker David J. Sherratt Maria Soledad Ramirez Marcelo E. Tolmasky Modules composed of a resistance gene flanked by Xer site-specific recombination sites, the vast majority of which were found in Acinetobacter...
Mon Jul 13, 2020 03:00
Antibiotics, Vol. 9, Pages 404: Antimicrobial Susceptibility and Characterization of Resistance Mechanisms of Corynebacterium urealyticum Clinical Isolates Antibiotics doi: 10.3390/antibiotics9070404 Authors: Itziar Chapartegui-González Marta Fernández-Martínez Ana Rodríguez-Fernández Danilo J. P. Rocha Eric R. G. R. Aguiar Luis G. C. Pacheco José Ramos-Vivas Jorge Calvo Luis Martínez-Martínez Jesús Navas Corynebacterium urealyticum is a non-diphtherial urease-producing...
Mon Jul 13, 2020 03:00
Antibodies, Vol. 9, Pages 32: Improving Receptor-Mediated Intracellular Access and Accumulation of Antibody Therapeutics—The Tale of HER2 Antibodies doi: 10.3390/antib9030032 Authors: Jeffrey V. Leyton Therapeutic anti-HER2 antibodies and antibody–drug conjugates (ADCs) have undoubtedly benefitted patients. Nonetheless, patients ultimately relapse—some sooner than others. Currently approved anti-HER2 drugs are expensive and their cost-effectiveness is debated. There...
Mon Jul 13, 2020 03:00
Antioxidants, Vol. 9, Pages 613: A Novel Combination of-Tocopherol-Rich Mixture of Tocopherols and Ascorbic Acid Restores Fertility in Cases of Tyrosine Nitration-Associated Male Infertility in Mice Antioxidants doi: 10.3390/antiox9070613 Authors: Scarlata Fernandez O’Flaherty Infertility is an important health problem that affects up to 16% of couples worldwide. Male infertility is responsible for 50% of the cases. Currently, a physical examination, hormone profiling and...
Mon Jul 13, 2020 03:00
Antioxidants, Vol. 9, Pages 614: Improvement of Health-Promoting Functionality of Rye Bread by Fortification with Free and Microencapsulated Powders from Amelanchier alnifolia Nutt. Antioxidants doi: 10.3390/antiox9070614 Authors: Lachowicz Świeca Pejcz This study established the appropriate amounts of a functional Saskatoon berry fruit powder in fortified rye bread acceptable to consumers and determined the potential relative bioaccesibility of bioactive compounds exhibiting...
Mon Jul 13, 2020 03:00
Arts, Vol. 9, Pages 80: From Horrors Past to Horrors Future: Pacifist War Art (1919–1939) Arts doi: 10.3390/arts9030080 Authors: Jannette In this paper, I argue that interwar pacifists working in France presented an evolving narrative of what the First World War represented in order to maintain support for their movement and a continued peace in Europe. Utilizing posters, photographs, pamphlets, and art instillations created by pacifist organizations, I interject in ongoing debates...
Mon Jul 13, 2020 03:00
Atmosphere, Vol. 11, Pages 742: Retrofit Strategies for Energy Efficiency of Historic Urban Fabric in Mediterranean Climate Atmosphere doi: 10.3390/atmos11070742 Authors: Ulu Durmuş Arsan Energy-efficient retrofitting of historic housing stock requires methodical approach, in-depth analysis and case-specific regulatory system, yet only limited efforts have been realized. In large scale rehabilitation projects, it is essential to develop a retrofit strategy on how to decide energy-efficient...
Mon Jul 13, 2020 03:00
Atmosphere, Vol. 11, Pages 743: The Influence of the Mineral–Microbial Deodorizing Preparation on Ammonia Emission and Growth Performance in Turkey Production Atmosphere doi: 10.3390/atmos11070743 Authors: Remigiusz Gałęcki Michał Dąbrowski Tadeusz Bakuła Kazimierz Obremski Mirosław Baranowski Adriana Nowak Beata Gutarowska In our previous in vitro research and also in laying hen production, attempts were made to minimise ammonia emissions in poultry houses with the...
Mon Jul 13, 2020 03:00
Atmosphere, Vol. 11, Pages 741: Workplace Biological Risk Assessment: Review of Existing and Description of a Comprehensive Approach Atmosphere doi: 10.3390/atmos11070741 Authors: Burzoni Duquenne Mater Ferrari Biological risks potentially affect workers in multiple occupational sectors through their exposure to pathogenic agents. These risks must be carefully assessed to prevent adverse health effects. This article identifies and critically analyzes approaches that manage...
Mon Jul 13, 2020 03:00
Atmosphere, Vol. 11, Pages 740: Interaction of a Low-Pressure System, an Offshore Trough, and Mid-Tropospheric Dry Air Intrusion: The Kerala Flood of August 2018 Atmosphere doi: 10.3390/atmos11070740 Authors: Vinay Kumar Prabodha Kumar Pradhan Tushar Sinha S. Vijaya Bhaskara Rao Hao-Po Chang The present study examines the Kerala Flood Event (KFE, 15–16 August 2018, in India) that occurred along the west coast of India and resulted in ~400 mm of rainfall in one day....
Mon Jul 13, 2020 03:00
Biology, Vol. 9, Pages 163: Cytotoxic, Antioxidant, and Enzyme Inhibitory Properties of the Traditional Medicinal Plant Matthiola incana (L.) R. Br. Biology doi: 10.3390/biology9070163 Authors: Maria Fernanda Taviano Natalizia Miceli Rosaria Acquaviva Giuseppe Antonio Malfa Salvatore Ragusa Deborah Giordano Guillermo Cásedas Francisco Les Víctor López Matthiola incana (L.) R. Br. (Brassicaceae) is widely cultivated for ornamental purposes and utilized as a medicinal...
Mon Jul 13, 2020 03:00
Biomedicines, Vol. 8, Pages 210: Endoplasmic Reticulum Stress in Macrophages: The Vicious Circle of Lipid Accumulation and Pro-Inflammatory Response Biomedicines doi: 10.3390/biomedicines8070210 Authors: Vasily N. Sukhorukov Victoria A. Khotina Mariam Bagheri Ekta Ekaterina A. Ivanova Igor A. Sobenin Alexander N. Orekhov The endoplasmic reticulum (ER) stress is an important event in the pathogenesis of different human disorders, including atherosclerosis. ER stress leads...
Mon Jul 13, 2020 03:00
Biomedicines, Vol. 8, Pages 209: Aggregate Removal Nanofiltration of Human Serum Albumin Solution Using Nanocellulose-Based Filter Paper Biomedicines doi: 10.3390/biomedicines8070209 Authors: Lulu Wu Athanasios Mantas Simon Gustafsson Levon Manukyan Albert Mihranyan This study is dedicated to the rapid removal of protein aggregates and viruses from plasma-derived human serum albumin (HSA) product to reduce the risk of viral contamination and increase biosafety. A two-step...
Mon Jul 13, 2020 03:00
Biomolecules, Vol. 10, Pages 1041: Untargeted LC-MS Metabolomics Differentiates Between Virulent and Avirulent Clinical Strains of Pseudomonas aeruginosa Biomolecules doi: 10.3390/biom10071041 Authors: Tobias Depke Janne Gesine Thöming Adrian Kordes Susanne Häussler Mark Brönstrup Pseudomonas aeruginosa is a facultative pathogen that can cause, inter alia, acute or chronic pneumonia in predisposed individuals. The gram-negative bacterium displays considerable genomic and...
Mon Jul 13, 2020 03:00
Biomolecules, Vol. 10, Pages 1042: A Novel C1-Esterase Inhibitor Oxygenator Coating Prevents FXII Activation in Human Blood Biomolecules doi: 10.3390/biom10071042 Authors: Gerling Ölschläger Avci-Adali Neumann Schweizer Schlensak Wendel Stoppelkamp The limited hemocompatibility of currently used oxygenator membranes prevents long-term use of artificial lungs in patients with lung failure. To improve hemocompatibility, we developed a novel covalent C1-esterase...
Mon Jul 13, 2020 03:00
Brain Sciences, Vol. 10, Pages 446: Contextual-Cueing beyond the Initial Field of View—A Virtual Reality Experiment Brain Sciences doi: 10.3390/brainsci10070446 Authors: Nico Marek Stefan Pollmann In visual search, participants can incidentally learn spatial target-distractor configurations, leading to shorter search times for repeated compared to novel configurations. Usually, this is tested within the limited visual field provided by a computer monitor. While contextual cueing is...
Mon Jul 13, 2020 03:00
Brain Sciences, Vol. 10, Pages 445: Sustained Isometric Wrist Flexion and Extension Maximal Voluntary Contractions on Corticospinal Excitability to Forearm Muscles during Low-Intensity Hand-Gripping Brain Sciences doi: 10.3390/brainsci10070445 Authors: Davis A. Forman Garrick N. Forman Bernadette A. Murphy Michael W. R. Holmes The wrist extensors demonstrate an earlier fatigue onset than the wrist flexors. However, it is currently unclear whether fatigue induces unique changes...
Mon Jul 13, 2020 03:00
Cancers, Vol. 12, Pages 1887: The Role of Cancer-Associated Fibroblasts in Prostate Cancer Tumorigenesis Cancers doi: 10.3390/cancers12071887 Authors: Francesco Bonollo George N. Thalmann Marianna Kruithof-de Kruithof-de Julio Sofia Karkampouna Tumors strongly depend on their surrounding tumor microenvironment (TME) for growth and progression, since stromal elements are required to generate the optimal conditions for cancer cell proliferation, invasion, and possibly metastasis....
Mon Jul 13, 2020 03:00
Cancers, Vol. 12, Pages 1886: Cancer Nanomedicine Special Issue Review Anticancer Drug Delivery with Nanoparticles: Extracellular Vesicles or Synthetic Nanobeads as Therapeutic Tools for Conventional Treatment or Immunotherapy Cancers doi: 10.3390/cancers12071886 Authors: Zocchi Tosetti Benelli Poggi Both natural and synthetic nanoparticles have been proposed as drug carriers in cancer treatment, since they can increase drug accumulation in target tissues, optimizing the...
Mon Jul 13, 2020 03:00
Cancers, Vol. 12, Pages 1882: CCR2 of Tumor Microenvironmental Cells Is a Relevant Modulator of Glioma Biology Cancers doi: 10.3390/cancers12071882 Authors: Matthäus Felsenstein Anne Blank Alexander D. Bungert Annett Mueller Adnan Ghori Irina Kremenetskaia Olga Rung Thomas Broggini Kati Turkowski Lea Scherschinski Jonas Raggatz Peter Vajkoczy Susan Brandenburg Glioblastoma multiforme (GBM) shows a high influx of tumor-associated macrophages (TAMs)....
Mon Jul 13, 2020 03:00
Cancers, Vol. 12, Pages 1883: Fast, In Vivo Model for Drug-Response Prediction in Patients with B-Cell Precursor Acute Lymphoblastic Leukemia Cancers doi: 10.3390/cancers12071883 Authors: Gauert Olk Pimentel-Gutiérrez Astrahantseff Jensen Cao Eggert Eckert Hagemann Only half of patients with relapsed B-cell precursor (BCP) acute lymphoblastic leukemia (ALL) currently survive with standard treatment protocols. Predicting individual patient responses to...
Mon Jul 13, 2020 03:00
Cancers, Vol. 12, Pages 1884: Current Trends of Artificial Intelligence for Colorectal Cancer Pathology Image Analysis: A Systematic Review Cancers doi: 10.3390/cancers12071884 Authors: Nishant Thakur Hongjun Yoon Yosep Chong Colorectal cancer (CRC) is one of the most common cancers requiring early pathologic diagnosis using colonoscopy biopsy samples. Recently, artificial intelligence (AI) has made significant progress and shown promising results in the field of medicine despite...
Mon Jul 13, 2020 03:00
Cancers, Vol. 12, Pages 1885: Correction: Ordoñez, et al.; DNA Methylation of Enhancer Elements in Myeloid Neoplasms: Think Outside the Promoters? Cancers 2019, 11, 1424 Cancers doi: 10.3390/cancers12071885 Authors: Ordoñez Martínez-Calle Agirre Prosper The authors would like to make a correction to their published paper [...]
Mon Jul 13, 2020 03:00
Cancers, Vol. 12, Pages 1881: Nitric Oxide (NO) and NO Synthases (NOS)-Based Targeted Therapy for Colon Cancer Cancers doi: 10.3390/cancers12071881 Authors: Hao Wang Liye Wang Zuoxu Xie Shuang Zhou Yan Li Yue Zhou Meiyan Sun Colorectal cancer (CRC) is one of the most lethal malignancies worldwide and CRC therapy remains unsatisfactory. In recent decades, nitric oxide (NO)—a free-radical gas—plus its endogenous producer NO synthases (NOS), have attracted...
Mon Jul 13, 2020 03:00
Cancers, Vol. 12, Pages 1880: Leucine-Rich Diet Modulates the Metabolomic and Proteomic Profile of Skeletal Muscle during Cancer Cachexia Cancers doi: 10.3390/cancers12071880 Authors: Bread Cruz André Oliveira Lais Rosa Viana Leisa Lopes-Aguiar Rafael Canevarolo Maiara Caroline Colombera Rafael Rossi Valentim Fernanda Garcia-Fóssa Lizandra Maia de Sousa Bianca Gazieri Castelucci Sílvio Roberto Consonni Daniel Martins-de-Souza Marcelo Bispo de Jesus Steven...
Mon Jul 13, 2020 03:00
Cancers, Vol. 12, Pages 1878: Radiosensitisation of Hepatocellular Carcinoma Cells by Vandetanib Cancers doi: 10.3390/cancers12071878 Authors: Sami Znati Rebecca Carter Marcos Vasquez Adam Westhorpe Hassan Shahbakhti Jessica Prince Petra Vlckova Chiara De Vellis Zainab Bascal Marilena Loizidou Ricky A. Sharma Hepatocellular Carcinoma (HCC) is increasing in incidence worldwide and requires new approaches to therapy. The combination of anti-angiogenic drug...
Mon Jul 13, 2020 03:00
Cancers, Vol. 12, Pages 1879: MiR-216b/Smad3/BCL-2 Axis Is Involved in Smoking-Mediated Drug Resistance in Non-Small Cell Lung Cancer Cancers doi: 10.3390/cancers12071879 Authors: Trung Vu Shanzhong Yang Pran K. Datta Epidemiologic studies have shown that vast majority of lung cancers (85–90%) are causally linked to tobacco smoking. Although much information has been gained about the effects of smoking on various signaling pathways, little is known about how deregulation...
Mon Jul 13, 2020 03:00
Cancers, Vol. 12, Pages 1877: The Biological Function of Sigma-2 Receptor/TMEM97 and Its Utility in PET Imaging Studies in Cancer Cancers doi: 10.3390/cancers12071877 Authors: Chenbo Zeng Aladdin Riad Robert H. Mach The sigma-2 receptor was originally defined pharmacologically and recently identified as TMEM97. TMEM97 has been validated as a biomarker of proliferative status and the radioligand of TMEM97, [18F]ISO-1, has been developed and validated as a PET imaging biomarker of...
Mon Jul 13, 2020 03:00
Cells, Vol. 9, Pages 1684: Fine Tuning of Calcium Constitutive Entry by Optogenetically-Controlled Membrane Polarization: Impact on Cell Migration Cells doi: 10.3390/cells9071684 Authors: Charles-Albert Chapotte-Baldacci Guénaëlle Lizot Cyrielle Jajkiewicz Manuella Lévêque Aubin Penna Christophe Magaud Vincent Thoreau Patrick Bois Stéphane Sebille Aurélien Chatelier Anomalies in constitutive calcium entry (CCE) have been commonly attributed to cell dysfunction...
Mon Jul 13, 2020 03:00
Cells, Vol. 9, Pages 1686: Slc38a1 Conveys Astroglia-Derived Glutamine into GABAergic Interneurons for Neurotransmitter GABA Synthesis Cells doi: 10.3390/cells9071686 Authors: Tayyaba Qureshi Mona Bjørkmo Kaja Nordengen Vidar Gundersen Tor Paaske Utheim Leiv Otto Watne Jon Storm-Mathisen Bjørnar Hassel Farrukh Abbas Chaudhry GABA signaling is involved in a wide range of neuronal functions, such as synchronization of action potential firing, synaptic plasticity...
Mon Jul 13, 2020 03:00
Cells, Vol. 9, Pages 1683: Inter-Tumor Heterogeneity—Melanomas Respond Differently to GM-CSF-Mediated Activation Cells doi: 10.3390/cells9071683 Authors: Adi Moshe Sivan Izraely Orit Sagi-Assif Sapir Malka Shlomit Ben-Menachem Tsipi Meshel Metsada Pasmanik-Chor Dave S.B. Hoon Isaac P. Witz Granulocyte-monocyte colony stimulating factor (GM-CSF) is used as an adjuvant in various clinical and preclinical studies with contradictory results. These were attributed...
Mon Jul 13, 2020 03:00
Cells, Vol. 9, Pages 1685: Loss of Function of the Gene Encoding the Histone Methyltransferase KMT2D Leads to Deregulation of Mitochondrial Respiration Cells doi: 10.3390/cells9071685 Authors: Consiglia Pacelli Iolanda Adipietro Natascia Malerba Gabriella Maria Squeo Claudia Piccoli Angela Amoresano Gabriella Pinto Pietro Pucci Ji-Eun Lee Kai Ge Nazzareno Capitanio Giuseppe Merla KMT2D encodes a methyltransferase responsible for histone 3 lysine 4 (H3K4)...
Mon Jul 13, 2020 03:00
Cells, Vol. 9, Pages 1680: Molecular Protein and Expression Profile in the Primary Tumors of Clear Cell Renal Carcinoma and Metastases Cells doi: 10.3390/cells9071680 Authors: Spirina Yurmazov Gorbunov Usynin Lushnikova Kovaleva Metastasis involves the spread of cancer cells from the primary tumor to surrounding tissues and distant organs and is the primary cause of cancer morbidity and mortality. The aim of the study was the determination of change in molecular...
Mon Jul 13, 2020 03:00
Cells, Vol. 9, Pages 1681: Addition of High Molecular Weight Hyaluronic Acid to Fibroblast-Like Stromal Cells Modulates Endogenous Hyaluronic Acid Metabolism and Enhances Proteolytic Processing and Secretion of Versican Cells doi: 10.3390/cells9071681 Authors: Jiapeng Xue Jinnan Chen Quan Shen Deva Chan Jun Li Adam P. Tanguay Tannin A. Schmidt Faizan Niazi Anna Plaas We have examined the effect of exogenous linear chain high molecular weight hyaluronic acid (HMW...
Mon Jul 13, 2020 03:00
Cells, Vol. 9, Pages 1679: The Ins and Outs of Cathepsins: Physiological Function and Role in Disease Management Cells doi: 10.3390/cells9071679 Authors: Yadati Houben Bitorina Shiri-Sverdlov Cathepsins are the most abundant lysosomal proteases that are mainly found in acidic endo/lysosomal compartments where they play a vital role in intracellular protein degradation, energy metabolism, and immune responses among a host of other functions. The discovery that cathepsins...
Mon Jul 13, 2020 03:00
Cells, Vol. 9, Pages 1682: Sphingosine-1-Phosphate Metabolism in the Regulation of Obesity/Type 2 Diabetes Cells doi: 10.3390/cells9071682 Authors: Jeanne Guitton Cecile L. Bandet Mohamed L. Mariko Sophie Tan-Chen Olivier Bourron Yacir Benomar Eric Hajduch Hervé Le Stunff Obesity is a pathophysiological condition where excess free fatty acids (FFA) target and promote the dysfunctioning of insulin sensitive tissues and of pancreatic β cells. This leads to...
Mon Jul 13, 2020 03:00
Cells, Vol. 9, Pages 1678: A Survey of Reported Disease-Related Mutations in the MRE11-RAD50-NBS1 Complex Cells doi: 10.3390/cells9071678 Authors: Samiur Rahman Marella D. Canny Tanner A. Buschmann Michael P. Latham The MRE11-RAD50-NBS1 (MRN) protein complex is one of the primary vehicles for repairing DNA double strand breaks and maintaining the genomic stability within the cell. The role of the MRN complex to recognize and process DNA double-strand breaks as well as signal...
Mon Jul 13, 2020 03:00
Chemosensors, Vol. 8, Pages 54: A Review: Electrochemical Biosensors for Oral Cancer Chemosensors doi: 10.3390/chemosensors8030054 Authors: Yen-Tzu Lin Sorour Darvishi Anant Preet Tzu-Yen Huang Sheng-Hsuan Lin Hubert H. Girault Ligang Wang Tzu-En Lin Oral cancer poses a serious threat worldwide owing to its soaring case-fatality rate and its metastatic characteristics of spreading to the other parts of the body. Despite the recent breakthroughs in biomedical sciences,...
M
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου