Antibiotics, Vol. 9, Pages 529: Medical-Grade Honey Kills Antibiotic-Resistant Bacteria and Prevents Amputation in Diabetics with Infected Ulcers: A Prospective Case Series Antibiotics doi: 10.3390/antibiotics9090529 Authors: Harikrishna K. R. Nair Nektarios Tatavilis Ivana Pospíšilová Jana Kučerová Niels A. J. Cremers Diabetic ulcers are at risk of becoming chronic and infected, as diabetics have hampered vascular structures, limiting oxygen and nutrient supply. These wounds...
Wed Aug 19, 2020 03:00
Antibiotics, Vol. 9, Pages 528: Ex Vivo Murine Skin Model for B. burgdorferi Biofilm Antibiotics doi: 10.3390/antibiotics9090528 Authors: Jason P. Torres Alireza G. Senejani Gauri Gaur Michael Oldakowski Krithika Murali Eva Sapi Borrelia burgdorferi, the causative agent of Lyme disease, has been recently shown to form biofilm structures in vitro and in vivo. Biofilms are tightly clustered microbes characterized as resistant aggregations that allow bacteria to withstand...
Wed Aug 19, 2020 03:00
Antibiotics, Vol. 9, Pages 527: Selective Eradication of Staphylococcus aureus by the Designer Genetically Programmed Yeast Biocontrol Agent Antibiotics doi: 10.3390/antibiotics9090527 Authors: Sofiya O. Pipiya Yuliana A. Mokrushina Alexander G. Gabibov Ivan V. Smirnov Stanislav S. Terekhov Staphylococcus aureus is a common human pathogen that is particularly often associated with antibiotic resistance. The eradication of this ubiquitous infectious agent from its ecological...
Wed Aug 19, 2020 03:00
Atmosphere, Vol. 11, Pages 884: Combining MWL and MSG SEVIRI Satellite Signals for Rainfall Detection and Estimation Atmosphere doi: 10.3390/atmos11090884 Authors: Kingsley K. Kumah Joost C. B. Hoedjes Noam David Ben H. P. Maathuis H. Oliver Gao Bob Z. Su Accurate rainfall detection and estimation are essential for many research and operational applications. Traditional rainfall detection and estimation techniques have achieved considerable success but with limitations....
Wed Aug 19, 2020 03:00
Atmosphere, Vol. 11, Pages 883: Long-Term Variability in Potential Evapotranspiration, Water Availability and Drought under Climate Change Scenarios in the Awash River Basin, Ethiopia Atmosphere doi: 10.3390/atmos11090883 Authors: Mahtsente Tadese Lalit Kumar Richard Koech Understanding the hydrological processes of a watershed in response to climate change is vital to the establishment of sustainable environmental management strategies. This study aimed to evaluate the variability...
Wed Aug 19, 2020 03:00
Beverages, Vol. 6, Pages 52: Mycotoxins in Functional Beverages: A Review Beverages doi: 10.3390/beverages6030052 Authors: Jéssica Gil-Serna Covadonga Vázquez Belén Patiño Consumer dietary habits have drastically changed in recent decades and functional beverages now have a strong position in the market. The majority of these beverages are produced using simple processes that use raw products, such as cereals, legumes, fruits, and nuts, among others, and these are known to be frequently...
Wed Aug 19, 2020 03:00
Bioengineering, Vol. 7, Pages 97: Pre-Clinical Cell Therapeutic Approaches for Repair of Volumetric Muscle Loss Bioengineering doi: 10.3390/bioengineering7030097 Authors: Mahdis Shayan Ngan F. Huang Extensive damage to skeletal muscle tissue due to volumetric muscle loss (VML) is beyond the inherent regenerative capacity of the body, and results in permanent functional debilitation. Current clinical treatments fail to fully restore native muscle function. Recently, cell-based therapies...
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Bioengineering, Vol. 7, Pages 98: Application of Fibre Bragg Grating Sensors in Strain Monitoring and Fracture Recovery of Human Femur Bone Bioengineering doi: 10.3390/bioengineering7030098 Authors: Ali Najafzadeh Dinusha Serandi Gunawardena Zhengyong Liu Ton Tran Hwa-Yaw Tam Jing Fu Bernard K. Chen Fibre Bragg Grating (FBG) sensors are gaining popularity in biomedical engineering. However, specific standards for in vivo testing for their use are absolutely limited....
Wed Aug 19, 2020 03:00
Bioengineering, Vol. 7, Pages 96: Mechanical Enhancement of Cytocompatible 3D Scaffolds, Consisting of Hydroxyapatite Nanocrystals and Natural Biomolecules, Through Physical Cross-Linking Bioengineering doi: 10.3390/bioengineering7030096 Authors: Despoina Brasinika Elias P. Koumoulos Kyriaki Kyriakidou Eleni Gkartzou Maria Kritikou Ioannis K. Karoussis Costas A. Charitidis Bioinspired scaffolds mimicking natural bone-tissue properties holds great promise in tissue engineering...
Wed Aug 19, 2020 03:00
Biomedicines, Vol. 8, Pages 292: Anticancer Imidazoacridinone C-1311 is Effective in Androgen-Dependent and Androgen-Independent Prostate Cancer Cells Biomedicines doi: 10.3390/biomedicines8090292 Authors: Magdalena Niemira Barbara Borowa-Mazgaj Samuel B. Bader Adrianna Moszyńska Marcin Ratajewski Kaja Karaś Mirosław Kwaśniewski Adam Krętowski Zofia Mazerska Ester M. Hammond Anna Skwarska The androgen receptor (AR) plays a critical role in prostate cancer...
Wed Aug 19, 2020 03:00
Biomolecules, Vol. 10, Pages 1204: Cellular and Molecular Mechanism of Cardiac Regeneration: A Comparison of Newts, Zebrafish, and Mammals Biomolecules doi: 10.3390/biom10091204 Authors: Lousanne de Wit Juntao Fang Klaus Neef Junjie Xiao Pieter A. Doevendans Raymond M. Schiffelers Zhiyong Lei Joost P.G. Sluijter Cardiovascular disease is the leading cause of death worldwide. Current palliative treatments can slow the progression of heart failure, but ultimately,...
Wed Aug 19, 2020 03:00
Biomolecules, Vol. 10, Pages 1205: Multivalent and Bidirectional Binding of Transcriptional Transactivation Domains to the MED25 Coactivator Biomolecules doi: 10.3390/biom10091205 Authors: Heather M. Jeffery Robert O. J. Weinzierl The human mediator subunit MED25 acts as a coactivator that binds the transcriptional activation domains (TADs) present in various cellular and viral gene-specific transcription factors. Previous studies, including on NMR measurements and site-directed mutagenesis,...
Wed Aug 19, 2020 03:00
Biomolecules, Vol. 10, Pages 1202: Expression and Purification of Recombinant GHK Tripeptides Are Able to Protect against Acute Cardiotoxicity from Exposure to Waterborne-Copper in Zebrafish Biomolecules doi: 10.3390/biom10091202 Authors: Chung-Der Hsiao Hsin-Hui Wu Nemi Malhotra Yen-Ching Liu Ying-Hsuan Wu Yu-Nung Lin Ferry Saputra Fiorency Santoso Kelvin H.-C. Chen In this study, an alternative method is developed to replace chemical synthesis to produce glycyl-histidyl-lysine...
Wed Aug 19, 2020 03:00
Biomolecules, Vol. 10, Pages 1203: Polymorphisms Involved in Response to Biological Agents Used in Rheumatoid Arthritis Biomolecules doi: 10.3390/biom10091203 Authors: Giovanni Pallio Federica Mannino Natasha Irrera Ali H. Eid Francesco Squadrito Alessandra Bitto Rheumatoid arthritis (RA) is a systemic disease that leads to joint destruction. During the last decade, the therapy of RA has been principally based on biological drugs. Although the efficacy of biological therapy...
Wed Aug 19, 2020 03:00
Biomolecules, Vol. 10, Pages 1201: Lipid Modulation in the Formation of β-Sheet Structures. Implications for De Novo Design of Human Islet Amyloid Polypeptide and the Impact on β-Cell Homeostasis Biomolecules doi: 10.3390/biom10091201 Authors: Israel Martínez-Navarro Raúl Díaz-Molina Angel Pulido-Capiz Jaime Mas-Oliva Ismael Luna-Reyes Eustolia Rodríguez-Velázquez Ignacio A. Rivero Marco A. Ramos-Ibarra Manuel Alatorre-Meda Victor García-González Human islet...
Wed Aug 19, 2020 03:00
Brain Sciences, Vol. 10, Pages 570: A Translational Study on Acute Traumatic Brain Injury: High Incidence of Epileptiform Activity on Human and Rat Electrocorticograms and Histological Correlates in Rats Brain Sciences doi: 10.3390/brainsci10090570 Authors: Ilia G. Komoltsev Mikhail V. Sinkin Aleksandra A. Volkova Elizaveta A. Smirnova Margarita R. Novikova Olga O. Kordonskaya Alexander E. Talypov Alla B. Guekht Vladimir V. Krylov Natalia V. Gulyaeva Background:...
Wed Aug 19, 2020 03:00
Brain Sciences, Vol. 10, Pages 569: Fatigue in Cancer and Neuroinflammatory and Autoimmune Disease: CNS Arousal Matters Brain Sciences doi: 10.3390/brainsci10090569 Authors: Christine Ulke Galina Surova Christian Sander Christoph Engel Kerstin Wirkner Philippe Jawinski Tilman Hensch Ulrich Hegerl The term fatigue is not only used to describe a sleepy state with a lack of drive, as observed in patients with chronic physical illnesses, but also a state with an inhibition...
Wed Aug 19, 2020 03:00
Brain Sciences, Vol. 10, Pages 568: Coordinated Human Brainstem and Spinal Cord Networks during the Expectation of Pain Have Elements Unique from Resting-State Effects Brain Sciences doi: 10.3390/brainsci10090568 Authors: Gabriela Ioachim Jocelyn M. Powers Howard J. M. Warren Patrick W. Stroman Functional magnetic resonance imaging (fMRI) research on the human brainstem (BS) and spinal cord (SC) has identified extensive BS/SC resting-state networks (RSNs) by showing spontaneous...
Wed Aug 19, 2020 03:00
Cancers, Vol. 12, Pages 2348: The Full Blood Count Blood Test for Colorectal Cancer Detection: A Systematic Review, Meta-Analysis, and Critical Appraisal Cancers doi: 10.3390/cancers12092348 Authors: Pradeep S. Virdee Ioana R. Marian Anita Mansouri Leena Elhussein Shona Kirtley Tim Holt Jacqueline Birks Introduction: A full blood count (FBC) blood test includes 20 components. We systematically reviewed studies that assessed the association of the FBC and diagnosis of...
Wed Aug 19, 2020 03:00
Cancers, Vol. 12, Pages 2345: Identification of Novel Fusion Genes in Bone and Soft Tissue Sarcoma and Their Implication in the Generation of a Mouse Model Cancers doi: 10.3390/cancers12092345 Authors: Yasuyo Teramura Miwa Tanaka Yukari Yamazaki Kyoko Yamashita Yutaka Takazawa Keisuke Ae Seiichi Matsumoto Takayuki Nakayama Takao Kaneko Yoshiro Musha Takuro Nakamura Fusion genes induced by chromosomal aberrations are common mutations causally associated with...
Wed Aug 19, 2020 03:00
Cancers, Vol. 12, Pages 2346: Diversity in the Extracellular Vesicle-Derived Microbiome of Tissues According to Tumor Progression in Pancreatic Cancer Cancers doi: 10.3390/cancers12092346 Authors: Jin-Yong Jeong Tae-Bum Kim Jinju Kim Hwi Wan Choi Eo Jin Kim Hyun Ju Yoo Song Lee Hye Ryeong Jun Wonbeak Yoo Seokho Kim Song Cheol Kim Eunsung Jun This study was conducted to identify the composition and diversity of the microbiome in tissues of pancreatic cancer...
Wed Aug 19, 2020 03:00
Cancers, Vol. 12, Pages 2339: Conditioning Intensity, Pre-Transplant Flow Cytometric Measurable Residual Disease, and Outcome in Adults with Acute Myeloid Leukemia Undergoing Allogeneic Hematopoietic Cell Transplantation Cancers doi: 10.3390/cancers12092339 Authors: Linde M. Morsink Brenda M. Sandmaier Megan Othus Raffaele Palmieri Noa Granot Evandro D. Bezerra Brent L. Wood Marco Mielcarek Gary Schoch Chris Davis Mary E. D. Flowers H. Joachim Deeg Frederick...
Wed Aug 19, 2020 03:00
Cancers, Vol. 12, Pages 2343: Hypoxia Predicts Poor Prognosis in Neuroblastoma Patients and Associates with Biological Mechanisms Involved in Telomerase Activation and Tumor Microenvironment Reprogramming Cancers doi: 10.3390/cancers12092343 Authors: Davide Cangelosi Martina Morini Nicolò Zanardi Angela Rita Sementa Marco Muselli Massimo Conte Alberto Garaventa Ulrich Pfeffer Maria Carla Bosco Luigi Varesio Alessandra Eva The biological and clinical heterogeneity...
Wed Aug 19, 2020 03:00
Cancers, Vol. 12, Pages 2336: Interphase Cytogenetic Analysis of G0 Lymphocytes Exposed to α-Particles, C-Ions, and Protons Reveals their Enhanced Effectiveness for Localized Chromosome Shattering—A Critical Risk for Chromothripsis Cancers doi: 10.3390/cancers12092336 Authors: Antonio Pantelias Demetre Zafiropoulos Roberto Cherubini Lucia Sarchiapone Viviana De Nadal Gabriel E. Pantelias Alexandros G. Georgakilas Georgia I. Terzoudi For precision cancer radiotherapy,...
Wed Aug 19, 2020 03:00
Cancers, Vol. 12, Pages 2344: A Mathematical Model to Predict Diagnostic Periods for Secondary Distant Metastases in Patients with ER/PR/HER2/Ki-67 Subtypes of Breast Cancer Cancers doi: 10.3390/cancers12092344 Authors: Ella Ya. Tyuryumina Alexey A. Neznanov Jacob L. Turumin Previously, a consolidated mathematical model of primary tumor (PT) growth and secondary distant metastasis (sdMTS) growth in breast cancer (BC) (CoMPaS) was presented. The aim was to detect the diagnostic...
Wed Aug 19, 2020 03:00
Cancers, Vol. 12, Pages 2341: The FMS like Tyrosine Kinase 3 (FLT3) Is Overexpressed in a Subgroup of Multiple Myeloma Patients with Inferior Prognosis Cancers doi: 10.3390/cancers12092341 Authors: Normann Steiner Karin Jöhrer Selina Plewan Andrea Brunner-Véber Georg Göbel David Nachbaur Dominik Wolf Eberhard Gunsilius Gerold Untergasser Therapy resistance remains a major challenge in the management of multiple myeloma (MM). We evaluated the expression of FLT3...
Wed Aug 19, 2020 03:00
Cancers, Vol. 12, Pages 2342: P2X7 Receptor Promotes Mouse Mammary Cancer Cell Invasiveness and Tumour Progression, and Is a Target for Anticancer Treatment Cancers doi: 10.3390/cancers12092342 Authors: Lucie Brisson Stéphanie Chadet Osbaldo Lopez-Charcas Bilel Jelassi David Ternant Julie Chamouton Stéphanie Lerondel Alain Le Pape Isabelle Couillin Aurélie Gombault Fabrice Trovero Stéphan Chevalier Pierre Besson Lin-Hua Jiang Sébastien Roger The...
Wed Aug 19, 2020 03:00
Cancers, Vol. 12, Pages 2335: Proteomic Analysis of Exosomes for Discovery of Protein Biomarkers for Prostate and Bladder Cancer Cancers doi: 10.3390/cancers12092335 Authors: Yi-Ting Wang Tujin Shi Sudhir Srivastava Jacob Kagan Tao Liu Karin D. Rodland Extracellular vesicles (EVs) are released by nearly all cell types as part of normal cell physiology, transporting biological cargo, including nucleic acids and proteins, across the cell membrane. In pathological states...
Wed Aug 19, 2020 03:00
Cancers, Vol. 12, Pages 2340: A Biobank of Colorectal Cancer Patient-Derived Xenografts Cancers doi: 10.3390/cancers12092340 Authors: Suad M. Abdirahman Michael Christie Adele Preaudet Marie C. U. Burstroem Dmitri Mouradov Belinda Lee Oliver M. Sieber Tracy L. Putoczki Colorectal cancer (CRC) is a challenging disease, with a high mortality rate and limited effective treatment options, particularly for late-stage disease. Patient-derived xenografts (PDXs) have emerged...
Wed Aug 19, 2020 03:00
Cancers, Vol. 12, Pages 2338: Is Host Metabolism the Missing Link to Improving Cancer Outcomes? Cancers doi: 10.3390/cancers12092338 Authors: Christopher M. Wright Anuradha A. Shastri Emily Bongiorno Ajay Palagani Ulrich Rodeck Nicole L. Simone For the past 100 years, oncologists have relentlessly pursued the destruction of tumor cells by surgical, chemotherapeutic or radiation oncological means. Consistent with this focus, treatment plans are typically based on key characteristics...
Wed Aug 19, 2020 03:00
Cancers, Vol. 12, Pages 2347: Practical Review on Preclinical Human 3D Glioblastoma Models: Advances and Challenges for Clinical Translation Cancers doi: 10.3390/cancers12092347 Authors: Aurélie Soubéran Aurélie Tchoghandjian Fifteen years after the establishment of the Stupp protocol as the standard of care to treat glioblastomas, no major clinical advances have been achieved and increasing patient’s overall survival remains a challenge. Nevertheless, crucial molecular...
Wed Aug 19, 2020 03:00
Cancers, Vol. 12, Pages 2334: Immunotherapy for Glioblastoma: Current State, Challenges, and Future Perspectives Cancers doi: 10.3390/cancers12092334 Authors: Minfeng Yang In Young Oh Arpan Mahanty Wei-Lin Jin Jung Sun Yoo Glioblastoma is the most lethal intracranial primary malignancy by no optimal treatment option. Cancer immunotherapy has achieved remarkable survival benefits against various advanced tumors, such as melanoma and non-small-cell lung cancer, thus triggering...
Wed Aug 19, 2020 03:00
Cancers, Vol. 12, Pages 2337: Oligonucleotides and microRNAs Targeting Telomerase Subunits in Cancer Therapy Cancers doi: 10.3390/cancers12092337 Authors: Adam Eckburg Joshua Dein Joseph Berei Zachary Schrank Neelu Puri Telomerase provides cancer cells with replicative immortality, and its overexpression serves as a near-universal marker of cancer. Anti-cancer therapeutics targeting telomerase have garnered interest as possible alternatives to chemotherapy and radiotherapy....
Wed Aug 19, 2020 03:00
Cells, Vol. 9, Pages 1925: The Diversity of Muscles and Their Regenerative Potential across Animals Cells doi: 10.3390/cells9091925 Authors: Letizia Zullo Matteo Bozzo Alon Daya Alessio Di Clemente Francesco Paolo Mancini Aram Megighian Nir Nesher Eric Röttinger Tal Shomrat Stefano Tiozzo Alberto Zullo Simona Candiani Cells with contractile functions are present in almost all metazoans, and so are the related processes of muscle homeostasis and regeneration....
Wed Aug 19, 2020 03:00
Cells, Vol. 9, Pages 1926: Conventional and Non-Conventional Roles of Non-Muscle Myosin II-Actin in Neuronal Development and Degeneration Cells doi: 10.3390/cells9091926 Authors: Javier-Torrent Saura Myosins are motor proteins that use chemical energy to produce mechanical forces driving actin cytoskeletal dynamics. In the brain, the conventional non-muscle myosin II (NMII) regulates actin filament cytoskeletal assembly and contractile forces during structural remodeling of axons...
Wed Aug 19, 2020 03:00
Cells, Vol. 9, Pages 1922: Altered Expression Ratio of Actin-Binding Gelsolin Isoforms Is a Novel Hallmark of Mitochondrial OXPHOS Dysfunction Cells doi: 10.3390/cells9091922 Authors: Alberto García-Bartolomé Ana Peñas María Illescas Verónica Bermejo Sandra López-Calcerrada Rafael Pérez-Pérez Lorena Marín-Buera Cristina Domínguez-González Joaquín Arenas Miguel A. Martín Cristina Ugalde Mitochondrial oxidative phosphorylation (OXPHOS) defects are the primary...
Wed Aug 19, 2020 03:00
Cells, Vol. 9, Pages 1923: A Systematic Review of Inverse Agonism at Adrenoceptor Subtypes Cells doi: 10.3390/cells9091923 Authors: Martin C. Michel Martina B. Michel-Reher Peter Hein As many, if not most, ligands at G protein-coupled receptor antagonists are inverse agonists, we systematically reviewed inverse agonism at the nine adrenoceptor subtypes. Except for β3-adrenoceptors, inverse agonism has been reported for each of the adrenoceptor subtypes, most often for...
Wed Aug 19, 2020 03:00
Cells, Vol. 9, Pages 1924: Microcurrent Stimulation Triggers MAPK Signaling and TGF-β1 Release in Fibroblast and Osteoblast-Like Cell Lines Cells doi: 10.3390/cells9091924 Authors: Evangelia Konstantinou Zoi Zagoriti Anastasia Pyriochou Konstantinos Poulas Wound healing constitutes an essential process for all organisms and involves a sequence of three phases. The disruption or elongation of any of these phases can lead to a chronic or non-healing wound. Electrical stimulation...
Wed Aug 19, 2020 03:00
Cells, Vol. 9, Pages 1920: 5-aza-2′-Deoxycytidine Induces a RIG-I-Related Innate Immune Response by Modulating Mitochondria Stress in Neuroblastoma Cells doi: 10.3390/cells9091920 Authors: Hung-Yu Lin Jiin-Haur Chuang Pei-Wen Wang Tsu-Kung Lin Min-Tsui Wu Wen-Ming Hsu Hui-Ching Chuang Background: Neuroblastoma (NB) is one of the most common malignant solid tumors to occur in children, characterized by a wide range of genetic and epigenetic aberrations. We studied whether...
Wed Aug 19, 2020 03:00
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