Comment on "Tracheostomy in COVID-19 Patients: Why Delay or Avoid?" Otolaryngol Head Neck Surg. 2020 Aug 18;:194599820953376 Authors: Goldman RA, Swendseid B, Cognetti DM PMID: 32808865 [PubMed - as supplied by publisher]
Wed Aug 19, 2020 14:58
Antibiotic Prophylaxis for Thyroid and Parathyroid Surgery: A Systematic Review and Meta-analysis. Otolaryngol Head Neck Surg. 2020 Aug 18;:194599820947700 Authors: Medas F, Canu GL, Cappellacci F, Romano G, Amato G, Erdas E, Calò PG Abstract OBJECTIVE: Although thyroid and parathyroid surgery is considered a clean procedure with a low incidence of surgical site infections (SSIs), a great number of endocrine surgeons use antibiotic prophylaxis...
Wed Aug 19, 2020 14:58
Management of Type 1 Laryngeal Clefts: A Systematic Review and Meta-analysis. Otolaryngol Head Neck Surg. 2020 Aug 18;:194599820947742 Authors: Timashpolsky A, Schild SD, Ballard DP, Leventer SP, Rosenfeld RM, Plum AW Abstract OBJECTIVE: Endoscopic surgical management or injection laryngoplasty of type 1 laryngeal clefts in pediatric patients is used in those who do not respond to conservative treatment. This study compares conservative...
Wed Aug 19, 2020 14:58
Comparative Study of Endoscopic and Microscopic Type I Tympanoplasty in Terms of Delayed Facial Palsy. Otolaryngol Head Neck Surg. 2020 Aug 18;:194599820945634 Authors: Li KH, Chan LP, Chen CK, Kuo SH, Wang LF, Chang NC, Wang HM, Ho KY, Chien CY Abstract OBJECTIVE: Delayed facial palsy is a complication of otologic surgery. Tympanoplasty is commonly employed in chronic otitis media. We compared the incidence and characteristics of delayed...
Wed Aug 19, 2020 14:58
An Integrated Care Strategy for the Follow-up of Patients With COVID-19-Associated Chemosensory Dysfunction. Otolaryngol Head Neck Surg. 2020 Aug 18;:194599820950716 Authors: Locatello LG, Maggiore G, Bruno C, Trotta M, Gallo O Abstract The proportion of patients with residual olfactory and gustatory dysfunction after COVID-19 is increasing, and practical health care strategies need to be developed to manage this novel situation in otolaryngology...
Wed Aug 19, 2020 14:58
Nonopioid, Multimodal Analgesia as First-line Therapy After Otolaryngology Operations: Primer on Nonsteroidal Anti-inflammatory Drugs (NSAIDs). Otolaryngol Head Neck Surg. 2020 Aug 18;:194599820947013 Authors: Cramer JD, Barnett ML, Anne S, Bateman BT, Rosenfeld RM, Tunkel DE, Brenner MJ Abstract OBJECTIVE: To offer pragmatic, evidence-informed advice on nonsteroidal anti-inflammatory drugs (NSAIDs) as first-line therapy after surgery....
Wed Aug 19, 2020 14:58
We Asked the Experts: Delivering Resilient Surgical Care in a Crisis-Five Survival Strategies for Front-Line Surgeons. World J Surg. 2020 Aug 17;: Authors: Gogalniceanu P, Bicknell C, Reader T, Sevdalis N, Mamode N PMID: 32808076 [PubMed - as supplied by publisher]
Wed Aug 19, 2020 16:48
Safety of Use of a Sheet-Type Adhesion Barrier (Interceed®) During Liver Surgery. World J Surg. 2020 Aug 17;: Authors: Okubo S, Shindoh J, Kobayashi Y, Hashimoto M Abstract BACKGROUND: Adhesion barriers are increasingly used in hepatobiliary surgery. However, there has been no solid evidence yet in support of their safety. METHODS: Incidences of global postoperative morbidities and major abdominal morbidities were compared between...
Wed Aug 19, 2020 16:48
Letter to the Editor: Largely Unchanged Annual Incidence and Overall Survival of Pleural Mesothelioma in the USA. World J Surg. 2020 Aug 17;: Authors: Lauer DJ, Mundt KA, Thompson WJ, Best EA PMID: 32808074 [PubMed - as supplied by publisher]
Wed Aug 19, 2020 16:48
Atypical teratoid/rhabdoid tumor of the cerebellum in an adult: case report and literature review. World Neurosurg. 2020 Aug 15;: Authors: Greeneway GP, Page PS, Patel V, Ahmed AS Abstract BACKGROUND: Atypical teratoid/rhabdoid tumor (AT/RT) is a rare tumor that is most frequently encountered in the pediatric patient population. AT/RT accounts for approximately 1-2% of all pediatric central nervous system (CNS) tumors and roughly 10-20% of...
Wed Aug 19, 2020 13:25
Risk Factors of Extended Hospital Stay after One Level Anterior Cervical Discectomy Fusion or Disc Replacement: Results from 1,004 Patients in FDA Trials. World Neurosurg. 2020 Aug 15;: Authors: Yoon TS, Greenberg AJ, Mummaneni PV, Shi WJ Abstract BACKGROUND: Extended LOS after surgery is costly to the healthcare system and can be distressing to the patient and family. Previous studies have shown conflicting data on factors associated with...
Wed Aug 19, 2020 13:25
Long-term outcomes of cerebral blood flow and neurotransmitter receptor function on 123I-iomazenil SPECT and of cognitive assessments after parent artery occlusion combined with cerebral revascularization for internal carotid artery aneurysms. World Neurosurg. 2020 Aug 15;: Authors: Kubo Y, Koji T, Murakami T, Yoshida K, Matsumoto Y, Ogasawara K Abstract OBJECTIVE: Many published studies of external-internal carotid artery bypass (EC-IC bypass)...
Wed Aug 19, 2020 13:25
COVID-19 pandemic and impact on mental health: recommendations for the neurosurgeon. World Neurosurg. 2020 Aug 15;: Authors: Lozada-Martínez I, Bolaño-Romero M, Moscote-Salazar L, Torres-Llinas D PMID: 32810630 [PubMed - as supplied by publisher]
Wed Aug 19, 2020 13:25
Indications and contraindications of full-endoscopic interlaminar lumbar decompression. World Neurosurg. 2020 Aug 15;: Authors: Wagner R, Haefner M Abstract OBJECTIVE: Spinal stenosis is a common disease with an increasing incidence. The narrowing of the spinal canal is caused by bone and soft tissue degeneration, such as osteophyte formation, facet and ligamentum flavum hypertrophy and disc herniation. Various surgical techniques have been...
Wed Aug 19, 2020 13:25
Lower total protein and absence of neuronavigation are novel poor prognostic factors of endoscopic hematoma removal for intracerebral hemorrhage. J Stroke Cerebrovasc Dis. 2020 Sep;29(9):105050 Authors: Katsuki M, Kakizawa Y, Nishikawa A, Yamamoto Y, Uchiyama T Abstract OBJECTIVES: Endoscopic hematoma removal is widely performed for the treatment of intracerebral hemorrhage. We investigated the factors related to the prognosis of intracerebral...
Wed Aug 19, 2020 14:35
microRNA-181a mediates the chemo-sensitivity of glioblastoma to carmustine and regulates cell proliferation, migration, and apoptosis. Eur J Pharmacol. 2020 Aug 15;:173483 Authors: Rezaei T, Hejazi M, Mansoori B, Mohammadi A, Amini M, Mosafer J, Rezaei S, Mokhtarzadeh A, Baradaran B Abstract Glioblastoma multiform (GBM) as the most frequent and lethal brain tumor is defined by aggressive invasiveness and considerable resistance to chemotherapy....
Wed Aug 19, 2020 13:23
The cross-talk between the Hippo signaling pathway and autophagy:implications on physiology and cancer. Cell Cycle. 2020 Aug 18;:1-10 Authors: Tang F, Christofori G Abstract Organ development is precisely guided by spatiotemporal cross-talks between a variety of signaling pathways regulating cell differentiation, proliferation, growth arrest and physiological cell death. Aberrant signaling inputs invariably lead to tissue dysfunction and...
Wed Aug 19, 2020 13:23
Allicin Overcomes Hypoxia Mediated Cisplatin Resistance in Lung Cancer Cells through ROS Mediated Cell Death Pathway and by Suppressing Hypoxia Inducible Factors. Cell Physiol Biochem. 2020 Aug 19;54(4):748-766 Authors: Pandey N, Tyagi G, Kaur P, Pradhan S, Rajam MV, Srivastava T Abstract BACKGROUND/AIMS: The hypoxic microenvironment in NSCLC has been widely accepted as a contributor to both therapeutic resistance and tumor progression....
Wed Aug 19, 2020 13:23
Tubular injury and cell-cycle arrest biomarkers to predict acute kidney injury in noncritically ill children receiving aminoglycosides. Biomark Med. 2020 Aug 18;: Authors: Chui H, Caldwell J, Yordanova M, Cockovski V, Fredric D, Harel-Sterling M, Haasz M, Al-Ismaili Z, Pizzi M, Ma Q, Devarajan P, Goldstein SL, Zappitelli M Abstract Aim: NGAL, IL-18, KIM-1 as well as urinary TIMP2 and IGFBP7 and their mathematical product (TIMP2*IGFBP7)...
Wed Aug 19, 2020 13:23
DNA-damage and cell cycle arrest initiated anti-cancer potency of super tiny carbon dots on MCF7 cell line. Sci Rep. 2020 Aug 17;10(1):13880 Authors: Şimşek S, Şüküroğlu AA, Yetkin D, Özbek B, Battal D, Genç R Abstract While carbon-based materials have spearheaded numerous breakthroughs in biomedicine, they also have procreated many logical concerns on their overall toxicity. Carbon dots (CDs) as a respectively new member have been extensively...
Wed Aug 19, 2020 13:23
Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints. Nat Commun. 2020 Aug 17;11(1):4124 Authors: Kong YW, Dreaden EC, Morandell S, Zhou W, Dhara SS, Sriram G, Lam FC, Patterson JC, Quadir M, Dinh A, Shopsowitz KE, Varmeh S, Yilmaz ÖH, Lippard SJ, Reinhardt HC, Hemann MT, Hammond PT, Yaffe MB Abstract In response to DNA damage, a synthetic lethal relationship...
Wed Aug 19, 2020 13:23
Anti-cancer effect of Urginea maritima bulb extract invitro through cell cycle arrest and induction of apoptosis in human breast cancer cell lines. Curr Drug Discov Technol. 2020 Aug 17;: Authors: Saket K, Salari R, Saburi E, Yousefi M, Khodadoust MA, Hadi M, Afshari JT Abstract BACKGROUND: Breast cancer is the most common known malignancy in women and it is therefore very important to prevent and treat this cancer. In this experimental...
Wed Aug 19, 2020 13:23
Thymoquinone-Loaded Soy-Phospholipid-Based Phytosomes Exhibit Anticancer Potential against Human Lung Cancer Cells. Pharmaceutics. 2020 Aug 12;12(8): Authors: Alhakamy NA, Badr-Eldin SM, A Fahmy U, Alruwaili NK, Awan ZA, Caruso G, Alfaleh MA, Alaofi AL, Arif FO, Ahmed OAA, Alghaith AF Abstract Thymoquinone (TQ), a natural polyphenol, has been associated with various pharmacological responses; however, low bioavailability of TQ limits its...
Wed Aug 19, 2020 13:23
Related Articles ATPR induces acute promyelocytic leukemia cells differentiation and growth arrest by blockade of SHP2/Rho/ROCK1 pathway. Toxicol Appl Pharmacol. 2020 07 15;399:115053 Authors: Li L, Xu X, Du Y, Zhang M, Feng Y, Qian X, Li S, Du T, Peng X, Chen F Abstract Acute promyelocytic leukemia (APL) is a form of acute myeloid leukemia with a unique chromosome translocation t (15;17), commonly complicated by a complex coagulopathy. 4-Amino-2-trifuoromethyl-phenyl...
Wed Aug 19, 2020 13:23
Related Articles Gene Therapy and Photothermal Therapy of Layer-by-Layer Assembled AuNCs /PEI/miRNA/ HA Nanocomplexes. Curr Cancer Drug Targets. 2019;19(4):330-337 Authors: Yan LJ, Guo XH, Wang WP, Hu YR, Duan SF, Liu Y, Sun Z, Huang SN, Li HL Abstract BACKGROUND: MicroRNA (miRNA) therapy, which was widely considered to treat a series of cancer, has been confronted with numerous obstacles to being delivered into target cells because of its...
Wed Aug 19, 2020 13:23
Epilepsy-related stigma and cost in two onchocerciasis-endemic areas in South Sudan: A pilot descriptive study. Seizure. 2020 Aug 11;81:151-156 Authors: Jada SR, Fodjo JNS, Abd-Elfarag G, Tionga M, Carter JY, Logora MY, Newton C, Colebunders R Abstract INTRODUCTION: Epilepsy is a major public health concern in sub-Saharan Africa, particularly in resource-limited rural villages where persons with epilepsy (PWE) are often confronted with a wide...
Wed Aug 19, 2020 15:24
The Impact of Clinical Seizure Characteristics on Recognition and Treatment of New-Onset Focal Epilepsy in Emergency Departments. Acad Emerg Med. 2020 Aug 18;: Authors: Pellinen J, Tafuro E, Baehr A, Barnard S, Holmes M, French J, Human Epilepsy Project investigators Abstract OBJECTIVE: Many people with new-onset focal epilepsy initially seek evaluation in emergency departments (EDs), and treatment decisions in EDs can influence likelihood...
Wed Aug 19, 2020 15:24
Maternal thyroid dysfunction during pregnancy and the risk of adverse outcomes in the offspring: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2020 Aug 18;: Authors: Ge GM, Leung MTY, Man KKC, Leung WC, Ip P, Li GHY, Wong ICK, Kung AWC, Cheung CL Abstract CONTEXT: Previous studies suggested a potential link of maternal thyroid dysfunction with adverse neurocognitive outcomes and impaired development of internal organs in offspring....
Wed Aug 19, 2020 15:24
CB1-Antibody Modified Liposomes for Targeted Modulation of Epileptiform Activities Synchronously Detected by Micro-Electrode Arrays. ACS Appl Mater Interfaces. 2020 Aug 18;: Authors: Dai Y, Song Y, Xie J, Xiao G, Li X, Li Z, Gao F, Zhang Y, He E, Xu S, Wang Y, Zheng W, Jiang X, Qi Z, Meng D, Fan Z, Cai X Abstract Temporal lobe epilepsy (TLE) is a focal, recurrent, and refractory neurological disorder. Therefore, precisely targeted treatments...
Wed Aug 19, 2020 15:24
Automatic localization and segmentation of focal cortical dysplasia in FLAIR-negative patients using a convolutional neural network. J Appl Clin Med Phys. 2020 Aug 18;: Authors: Feng C, Zhao H, Li Y, Wen J Abstract PURPOSE: Focal cortical dysplasia (FCD) is a common cause of epilepsy; the only treatment is surgery. Therefore, detecting FCD using noninvasive imaging technology can help doctors determine whether surgical intervention is required....
Wed Aug 19, 2020 15:24
Cardiovascular safety of fenfluramine in the treatment of Dravet syndrome: Analysis of an ongoing long-term open-label safety extension study. Epilepsia. 2020 Aug 18;: Authors: Lai WW, Galer BS, Wong PC, Farfel G, Pringsheim M, Keane MG, Agarwal A Abstract OBJECTIVE: Fenfluramine, which was previously approved as a weight loss drug, was withdrawn in 1997 when reports of cardiac valvulopathy emerged. The present study was conducted in part to...
Wed Aug 19, 2020 15:24
Consequences of NMDA receptor deficiency can be rescued in the adult brain. Mol Psychiatry. 2020 Aug 17;: Authors: Mielnik CA, Binko MA, Chen Y, Funk AJ, Johansson EM, Intson K, Sivananthan N, Islam R, Milenkovic M, Horsfall W, Ross RA, Groc L, Salahpour A, McCullumsmith RE, Tripathy S, Lambe EK, Ramsey AJ Abstract N-methyl-D-aspartate receptors (NMDARs) are required to shape activity-dependent connections in the developing and adult brain....
Wed Aug 19, 2020 15:24
Post-stroke complex regional pain syndrome and related factors: Experiences from a tertiary rehabilitation center. J Stroke Cerebrovasc Dis. 2020 Sep;29(9):104995 Authors: Altas EU, Onat ŞŞ, Konak HE, Polat CS Abstract OBJECTIVE: In this study, it is aimed to determine the risk factors associated with CRPS after stroke and the clinical parameters of the patients and the treatment agents used for CPRS METHOD: 213 hemiplegic patients with CRPS...
Wed Aug 19, 2020 15:24
Differential Expression of Multiple Disease-Related Protein Groups Induced by Valproic Acid in Human SH-SY5Y Neuroblastoma Cells. Brain Sci. 2020 Aug 12;10(8): Authors: Hu TM, Chung HS, Ping LY, Hsu SH, Tsai HY, Chen SJ, Cheng MC Abstract Valproic acid (VPA) is a multifunctional medication used for the treatment of epilepsy, mania associated with bipolar disorder, and migraine. The pharmacological effects of VPA involve a variety of neurotransmitter...
Wed Aug 19, 2020 15:24
Related Articles Vigabatrin Toxicity in a Patient with Infantile Spasms Treated with Concomitant Hormonal Therapy. Isr Med Assoc J. 2020 Jul;7(22):395-396 Authors: Lotan E, Bluvstein J, Zan E PMID: 32692506 [PubMed - indexed for MEDLINE]
Wed Aug 19, 2020 15:24
Related Articles Anti-epileptic activity, toxicity and teratogenicity in CD1 mice of a novel valproic acid arylamide derivative, N-(2-hydroxyphenyl)-2-propylpentanamide. Toxicol Appl Pharmacol. 2020 07 15;399:115033 Authors: Cristóbal-Luna JM, Correa-Basurto J, Mendoza-Figueroa HL, Chamorro-Cevallos G Abstract N-(2-hydroxyphenyl)-2-propylpentamide (HO-AAVPA) is a novel arylamide derivative of valproic acid (VPA) designed in silico, with better...
Wed Aug 19, 2020 15:24
Related Articles Contralateral Preoperative Resting-State Functional MRI Network Integration Is Associated with Surgical Outcome in Temporal Lobe Epilepsy. Radiology. 2020 03;294(3):622-627 Authors: DeSalvo MN, Tanaka N, Douw L, Cole AJ, Stufflebeam SM Abstract Background Although most patients with medically refractory temporal lobe epilepsy (TLE) experience seizure freedom after anterior temporal lobectomy, approximately 40% may continue to...
Wed Aug 19, 2020 15:24
Related Articles Alzheimer-like amyloid and tau alterations associated with cognitive deficit in temporal lobe epilepsy. Brain. 2020 01 01;143(1):191-209 Authors: Gourmaud S, Shou H, Irwin DJ, Sansalone K, Jacobs LM, Lucas TH, Marsh ED, Davis KA, Jensen FE, Talos DM Abstract Temporal lobe epilepsy represents a major cause of drug-resistant epilepsy. Cognitive impairment is a frequent comorbidity, but the mechanisms are not fully elucidated....
Wed Aug 19, 2020 15:24
Related Articles Can We Justify It? Trends in the Utilization of Spinal Fusions and Associated Reimbursement. Neurosurgery. 2020 02 01;86(2):E193-E202 Authors: Sheikh SR, Thompson NR, Benzel E, Steinmetz M, Mroz T, Tomic D, Machado A, Jehi L Abstract BACKGROUND: Previous reports have suggested an increasing rate of utilization of spinal fusions, but contemporary data have not been analyzed, and there has been little investigation of putative...
Wed Aug 19, 2020 15:24
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