Nature Communications, Published online: 19 August 2020; doi:10.1038/s41467-020-17938-3Directing the position, orientation, and long-range lateral order of block copolymer domains to produce technologically-useful, sublithographic patterns is a challenge. Here, the authors present a promising approach to overcome the challenge by directing assembly using spatial boundaries between planar, low-resolution regions on a surface with different composition.
Nature Communications, Published online: 19 August 2020; doi:10.1038/s41467-020-18013-7Histone methyltransferase, DOTL1 is implicated in the pathogenesis of MLL-rearranged leukemia, however, not much is known of its role in prostate cancer (PCa). Here, the authors report that DOTL1 inhibition suppresses both androgen receptor and MYC pathways in a negative feed forward manner to reduce growth of AR-positive PCa.
Nature Communications, Published online: 19 August 2020; doi:10.1038/s41467-020-17814-0The feasibility of molecular assemblers as a device to control chemical reactions by positioning molecules with atomic precision is a matter of debate in the literature. Here the authors describe of a rudimentary synthetic molecular assembler, supramolecular aggregate of bifunctional surfactants produced by the reaction of two phase-separated reactants that produces polymers.
Nature Communications, Published online: 19 August 2020; doi:10.1038/s41467-020-17726-zThe average body size of salmon has declined rapidly over recent decades. Here the authors quantify changes in body size distributions for Pacific salmon in Alaska and examine the causes and consequences of size declines for ecosystems, food security, and commercial fisheries.
Nature Communications, Published online: 19 August 2020; doi:10.1038/s41467-020-17835-9To optimize operating conditions of large scale semiconductor quantum devices, a large parameter space has to be explored. Here, the authors report a machine learning algorithm to navigate the entire parameter space of gate-defined quantum dot devices, showing about 180 times faster than a pure random search.
Nature Communications, Published online: 19 August 2020; doi:10.1038/s41467-020-17961-4The relationship between DNA damage response (DDR) and regulation of the tolerance to glucose restriction is currently unclear. Here the authors reveal that maintaining a physiological level of histones by Rad53-Spt21 is necessary for glucose tolerance via multiple parallel pathways, including derepression of subtelomeric genes and acetyl-coA regulation by histone acetylation.
Nature Communications, Published online: 19 August 2020; doi:10.1038/s41467-020-17709-0Swarming bacterial populations can exhibit antibiotic resistance, despite sustaining considerable cell death. Here, Bhattacharyya et al. show that killed cells release periplasmic protein AcrA, which activates efflux pumps on the surface of live cells, thus enhancing antibiotic resistance in the surviving cells.
Nature Communications, Published online: 19 August 2020; doi:10.1038/s41467-020-18023-5Author Correction: The solute carrier SLC9C1 is a Na+/H+-exchanger gated by an S4-type voltage-sensor and cyclic-nucleotide binding
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