Publication date: Available online 1 February 2018
Source:Revue des Maladies Respiratoires
Author(s): S. Messous, M.H. Grissa, K. Beltaief, R. Boukef, S. Nouira, M. Mastouri
IntroductionLe rôle des bactéries, y compris les germes atypiques, dans les exacerbations aiguës de la bronchopneumopathie chronique obstructive (EABPCO) en Tunisie a été diversement apprécié.MéthodesÉtude descriptive et analytique incluant des patients d'âge moyen de 68,3±10,5 ans hospitalisés pour EABPCO. L'examen bactériologique comprend un examen cytobactériologique de crachat et une sérologie des germes atypiques incluant Mycoplasma pneumoniae, Coxiella burnetii, Chlamydophila pneumoniae et Legionella pneumophila selon les techniques standard.RésultatsSur les 240 patients inclus, 175 cultures de crachat (73 %) ont été considérées comme significatives. Vingt-neuf cultures étaient positives (16,5 %) et 31 germes ont été isolés dont les plus fréquents étaient P. aeruginosa (25,8 %), K. pneumoniae (16,2 %), H. influenzae (13 %) et S. pneumoniae (9,7 %). La prévalence de l'infection à C. pneumoniae, M. pneumoniae et C. burnetii était respectivement de 8,4 %, 9 % et 6,6 %. Aucune infection à L. pneumophila n'a été retrouvée. Les critères d'Anthonisen étaient associés à une culture positive (p=0,04). Près de la moitié (40,9 %) des souches isolées étaient résistantes aux antibiotiques classiques de première intention (43,7 % pour amoxicilline-acide clavulanique).ConclusionsLa faible positivité de la bactériologie quantitative des crachats et l'important pourcentage des souches résistantes avec une prédominance des Pseudomonas exclusivement multirésistantes peuvent aider dans la prise en charge des patients en EABPCO.IntroductionThe role of bacteria, including atypical organisms, in acute exacerbations of chronic obstructive pulmonary disease (AECOPD) has been assessed in various ways in Tunisia.MethodsThis was a descriptive and analytical study of patients with a mean age of 68.3±10.5 years hospitalized for AECOPD. Bacteriological examination included a cytological sputum exam and serology for atypical organisms including Mycoplasma pneumoniae, Coxiella burnetii, Chlamydophila pneumoniae and Legionella pneumophila using standard techniques.ResultsOf the 240 patients enrolled, 175 sputum cultures (73%) were considered significant. Twenty-nine cultures were positive (16.5%) and 31 microorganisms were isolated of which the most frequent were P. aeruginosa (25.8%), K. pneumoniae (16.2%), H. influenzae (13%) and S. pneumoniae (9.7%). The prevalence of C. pneumoniae, M. pneumoniae and C. burnetii was 8.4%, 9% and 6.6%, respectively. No L. pneumophila infection was found. The Anthonisen criteria were associated with a positive culture (P=0.04). Almost half (40.9%) of the isolates were resistant to conventional first line antibiotics (43.7% to amoxicillin-clavulanic acid).ConclusionsAwareness of the low positivity of quantitative sputum bacteriology and the large percentage of resistant strains with a predominance of exclusively multi-resistant Pseudomonas should help in the management of patients with AECOPD.
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Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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Bactériologie des exacerbations aiguës des bronchopneumopathies chroniques obstructives en Tunisie
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