IJMS, Vol. 21, Pages 4624: Plasma Extracellular Vesicle-Derived TIMP-1 mRNA as a Prognostic Biomarker in Clear Cell Renal Cell Carcinoma: A Pilot Study International Journal of Molecular Sciences doi: 10.3390/ijms21134624 Authors: Francisca Dias Ana Luísa Teixeira Inês Nogueira Mariana Morais Joana Maia Cristian Bodo Marta Ferreira Isabel Vieira José Silva João Lobo José Pedro Sequeira Joaquina Maurício Jorge Oliveira Carlos Palmeira Gabriela Martins...
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IJMS, Vol. 21, Pages 4620: Effects of Apigenin on RBL-2H3, RAW264.7, and HaCaT Cells: Anti-Allergic, Anti-Inflammatory, and Skin-Protective Activities International Journal of Molecular Sciences doi: 10.3390/ijms21134620 Authors: Park Min Yu Kim Kim Lee Kim Park Apigenin (4′,5,7-trihydroxyflavone, flavonoid) is a phenolic compound that is known to reduce the risk of chronic disease owing to its low toxicity. The first study on apigenin analyzed...
Mon Jun 29, 2020 03:00
IJMS, Vol. 21, Pages 4619: Protocatechuic Aldehyde Attenuates UVA-Induced Photoaging in Human Dermal Fibroblast Cells by Suppressing MAPKs/AP-1 and NF-κB Signaling Pathways International Journal of Molecular Sciences doi: 10.3390/ijms21134619 Authors: Ding Jiratchayamaethasakul Lee Ultraviolet radiation (UV) is a major causative factor of DNA damage, inflammatory responses, reactive oxygen species (ROS) generation and a turnover of various cutaneous lesions resulting in skin...
Mon Jun 29, 2020 03:00
IJMS, Vol. 21, Pages 4621: Pharmacological Treatment of Alzheimer’s Disease: Insights from Drosophila melanogaster International Journal of Molecular Sciences doi: 10.3390/ijms21134621 Authors: Xingyi Cheng Chaochun Song Yanjiao Du Uma Gaur Mingyao Yang Aging is an ineluctable law of life. During the process of aging, the occurrence of neurodegenerative disorders is prevalent in the elderly population and the predominant type of dementia is Alzheimer’s disease (AD)....
Mon Jun 29, 2020 03:00
IJMS, Vol. 21, Pages 4617: Bispicolyamine-Based Supramolecular Polymeric Gels Induced by Distinct Different Driving Forces with and without Zn2+ International Journal of Molecular Sciences doi: 10.3390/ijms21134617 Authors: Park Kim Kang Lee Lee Jung Metal-coordination polymeric gels are interesting areas as organic/inorganic hybrid supramolecular materials. The bispicolylamine (BPA) based gelator (1) showed excellent gelation with typical fibrillar morphology in...
Mon Jun 29, 2020 03:00
IJMS, Vol. 21, Pages 4616: Genetic Variants in the FGB and FGG Genes Mapping in the Beta and Gamma Nodules of the Fibrinogen Molecule in Congenital Quantitative Fibrinogen Disorders Associated with a Thrombotic Phenotype International Journal of Molecular Sciences doi: 10.3390/ijms21134616 Authors: Simurda Brunclikova Asselta Caccia Zolkova Kolkova Loderer Skornova Hudecek Lasabova Stasko Kubisz Fibrinogen is a hexameric plasmatic glycoprotein...
Mon Jun 29, 2020 03:00
IJMS, Vol. 21, Pages 4618: An Overview of Coumarin as a Versatile and Readily Accessible Scaffold with Broad-Ranging Biological Activities International Journal of Molecular Sciences doi: 10.3390/ijms21134618 Authors: Francesca Annunziata Cecilia Pinna Sabrina Dallavalle Lucia Tamborini Andrea Pinto Privileged structures have been widely used as an effective template for the research and discovery of high value chemicals. Coumarin is a simple scaffold widespread in Nature...
Mon Jun 29, 2020 03:00
IJMS, Vol. 21, Pages 4613: -19054399851500The Diverse Piscidin Repertoire of the European Sea Bass (Dicentrarchus labrax): Molecular Characterization and Antimicrobial Activities International Journal of Molecular Sciences doi: 10.3390/ijms21134613 Authors: Barroso Carvalho Carvalho Santarém Gonçalves Rodrigues Neves Fish rely on their innate immune responses to cope with the challenging aquatic environment, with antimicrobial peptides (AMPs) being one of the...
Mon Jun 29, 2020 03:00
IJMS, Vol. 21, Pages 4610: Molecular Evidence that Lysiphlebia japonica Regulates the Development and Physiological Metabolism of Aphis gossypii International Journal of Molecular Sciences doi: 10.3390/ijms21134610 Authors: Gao Xue Luo Ji Zhang Niu Zhu Wang Zhang Cui Lysiphlebia japonica Ashmead (Hymenoptera, Braconidae) is an endophagous parasitoid and Aphis gossypii Glover (Hemiptera, Aphididae) is a major pest in cotton. The relationship between...
Mon Jun 29, 2020 03:00
IJMS, Vol. 21, Pages 4615: Integrated RNA-Seq Analysis and Meta-QTLs Mapping Provide Insights into Cold Stress Response in Rice Seedling Roots International Journal of Molecular Sciences doi: 10.3390/ijms21134615 Authors: Weilong Kong Chenhao Zhang Yalin Qiang Hua Zhong Gangqing Zhao Yangsheng Li Rice (Oryza sativa L.) is a widely cultivated food crop around the world, especially in Asia. However, rice seedlings often suffer from cold stress, which affects their growth...
Mon Jun 29, 2020 03:00
IJMS, Vol. 21, Pages 4612: Special Issue on “The Tight Junction and Its Proteins: More than Just a Barrier” International Journal of Molecular Sciences doi: 10.3390/ijms21134612 Authors: Krug Fromm For a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ—mainly, the two families of claudins and TAMPs—several...
Mon Jun 29, 2020 03:00
IJMS, Vol. 21, Pages 4611: Cytotoxic Effect of Vanicosides A and B from Reynoutria sachalinensis Against Melanotic and Amelanotic Melanoma Cell Lines and in silico Evaluation for Inhibition of BRAFV600E and MEK1 International Journal of Molecular Sciences doi: 10.3390/ijms21134611 Authors: Nawrot-Hadzik Choromańska Abel Preissner Saczko Matkowski Hadzik Vanicosides A and B are the esters of hydroxycinnamic acids with sucrose, occurring in a few plant species...
Mon Jun 29, 2020 03:00
IJMS, Vol. 21, Pages 4614: Transcriptional Regulators and Human-Specific/Primate-Specific Genes in Neocortical Neurogenesis International Journal of Molecular Sciences doi: 10.3390/ijms21134614 Authors: Vaid Huttner During development, starting from a pool of pluripotent stem cells, tissue-specific genetic programs help to shape and develop functional organs. To understand the development of an organ and its disorders, it is important to understand the spatio-temporal dynamics of...
Mon Jun 29, 2020 03:00
IJMS, Vol. 21, Pages 4608: Lactobacillus plantarum DR7 Modulated Bowel Movement and Gut Microbiota Associated with Dopamine and Serotonin Pathways in Stressed Adults International Journal of Molecular Sciences doi: 10.3390/ijms21134608 Authors: Liu Chong Chung Li Liong We have previously reported that the administration of Lactobacillus plantarum DR7 for 12 weeks reduced stress and anxiety in stressed adults as compared to the placebo group, in association with changes...
Mon Jun 29, 2020 03:00
IJMS, Vol. 21, Pages 4609: HMGB1-Mediated Neuroinflammatory Responses in Brain Injuries: Potential Mechanisms and Therapeutic Opportunities International Journal of Molecular Sciences doi: 10.3390/ijms21134609 Authors: Yam Nath Paudel Efthalia Angelopoulou Christina Piperi Iekhsan Othman Mohd. Farooq Shaikh Brain injuries are devastating conditions, representing a global cause of mortality and morbidity, with no effective treatment to date. Increased evidence supports the...
Mon Jun 29, 2020 03:00
IJMS, Vol. 21, Pages 4606: Exploration of the Effects of Different Blue LED Light Intensities on Flavonoid and Lipid Metabolism in Tea Plants via Transcriptomics and Metabolomics International Journal of Molecular Sciences doi: 10.3390/ijms21134606 Authors: Wang Chen Gu Chen Chen Yang Zhao Ye Blue light extensively regulates multiple physiological processes and secondary metabolism of plants. Although blue light quantity (fluence rate) is important for plant...
Mon Jun 29, 2020 03:00
IJMS, Vol. 21, Pages 4604: Burns in the Elderly: Potential Role of Stem Cells International Journal of Molecular Sciences doi: 10.3390/ijms21134604 Authors: Margarita Elloso Ankita Kambli Ayesha Aijaz Alex van de Kamp Mark G. Jeschke Burns in the elderly continue to be a challenge despite advances in burn wound care management. Elderly burn patients continue to have poor outcomes compared to the younger population. This is secondary to changes in the quality of the aged skin,...
Mon Jun 29, 2020 03:00
IJMS, Vol. 21, Pages 4607: Abscisic Acid—Enemy or Savior in the Response of Cereals to Abiotic and Biotic Stresses? International Journal of Molecular Sciences doi: 10.3390/ijms21134607 Authors: Gietler Fidler Labudda Nykiel Abscisic acid (ABA) is well-known phytohormone involved in the control of plant natural developmental processes, as well as the stress response. Although in wheat (Triticum aestivum L.) and barley (Hordeum vulgare L.) its role in mechanism of the tolerance...
Mon Jun 29, 2020 03:00
IJMS, Vol. 21, Pages 4605: Self-Organized Liver Microtissue on a Bio-Functional Surface: The Role of Human Adipose-Derived Stromal Cells in Hepatic Function International Journal of Molecular Sciences doi: 10.3390/ijms21134605 Authors: Hong Oh Choi Hwang Kim The maintenance of hepatocyte function is a critical research topic in liver tissue engineering. Although an increasing number of strategies have been developed, liver tissue engineering using hepatocytes as a therapeutic...
Mon Jun 29, 2020 03:00
IJMS, Vol. 21, Pages 4603: Heterologous Expression of Dehydration-Inducible MfWRKY17 of Myrothamnus Flabellifolia Confers Drought and Salt Tolerance in Arabidopsis International Journal of Molecular Sciences doi: 10.3390/ijms21134603 Authors: Huang Guo Liu Jin Zhu Zhang Jiang : As the only woody resurrection plant, Myrothamnus flabellifolia has a strong tolerance to drought and can survive long-term in a desiccated environment. However, the molecular mechanisms...
Mon Jun 29, 2020 03:00
IJMS, Vol. 21, Pages 4602: Martini Coarse-Grained Model of Hyaluronic Acid for the Structural Change of Its Gel in the Presence of Monovalent and Divalent Salts International Journal of Molecular Sciences doi: 10.3390/ijms21134602 Authors: Raj Kumar YoungKyu Lee YongSeok Jho Hyaluronic acid (HA) has a wide range of biomedical applications including the formation of hydrogels, microspheres, sponges, and films. The modeling of HA to understand its behavior and interaction with other...
Mon Jun 29, 2020 03:00
JCM, Vol. 9, Pages 2052: A Physiologic Approach to Hemodynamic Monitoring and Optimizing Oxygen Delivery in Shock Resuscitation Journal of Clinical Medicine doi: 10.3390/jcm9072052 Authors: Amy Russell Emanuel P. Rivers Paresh C. Giri Anja K. Jaehne H. Bryant Nguyen The approach to shock resuscitation focuses on all components of oxygen delivery, including preload, afterload, contractility, hemoglobin, and oxygen saturation. Resuscitation focused solely on preload and fluid...
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JCM, Vol. 9, Pages 2050: Role of Lopinavir/Ritonavir in the Treatment of Covid-19: A Review of Current Evidence, Guideline Recommendations, and Perspectives Journal of Clinical Medicine doi: 10.3390/jcm9072050 Authors: Simone Meini Alberto Pagotto Benedetta Longo Igor Vendramin Davide Pecori Carlo Tascini A life-threatening respiratory illness (COVID-19) due to severe acute respiratory syndrome (SARS)-CoV-2 coronavirus was first described in December 2019 in Wuhan (China),...
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JCM, Vol. 9, Pages 2049: Peptidyl Arginine Deiminase Type 4 Gene Promoter Hypo-Methylation in Rheumatoid Arthritis Journal of Clinical Medicine doi: 10.3390/jcm9072049 Authors: Bogdan Kolarz Marek Ciesla Magdalena Dryglewska Maria Majdan Protein citrullination is carried out by peptidylarginine deiminase type 4 (PAD4) enzyme. As a consequence of this process, post-translationally modified proteins are formed that become antigens for anti-citrullinated protein antibodies (ACPA)....
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JCM, Vol. 9, Pages 2051: Vasopressors and Inotropes in Acute Myocardial Infarction Related Cardiogenic Shock: A Systematic Review and Meta-Analysis Journal of Clinical Medicine doi: 10.3390/jcm9072051 Authors: Mina Karami Veemal V. Hemradj Dagmar M. Ouweneel Corstiaan A. den den Uil Jacqueline Limpens Luuk C. Otterspoor Alexander P. Vlaar Wim K. Lagrand José P. S. Henriques Vasopressors and inotropes are routinely used in acute myocardial infarction (AMI) related...
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JCM, Vol. 9, Pages 2048: Immunomodulation by an Omega-6 Fatty Acid Reduced Mixed Lipid Emulsion in Murine Acute Respiratory Distress Syndrome Journal of Clinical Medicine doi: 10.3390/jcm9072048 Authors: Matthias Hecker Matthias Rose Andreas Hecker Hartmut Dietrich Martina B. Schaefer Natascha Sommer Werner Seeger Konstantin Mayer Background: Acute respiratory distress syndrome (ARDS) is associated with both high morbidity and mortality in intensive care units worldwide....
Mon Jun 29, 2020 03:00
JCM, Vol. 9, Pages 2047: Bioactive Surfaces vs. Conventional Surfaces in Titanium Dental Implants: A Comparative Systematic Review Journal of Clinical Medicine doi: 10.3390/jcm9072047 Authors: Nansi López-Valverde Javier Flores-Fraile Juan Manuel Ramírez Bruno Macedo de Sousa Silvia Herrero-Hernández Antonio López-Valverde Animal studies and the scarce clinical trials available that have been conducted suggest that bioactive surfaces on dental implants could improve the...
Mon Jun 29, 2020 03:00
JCM, Vol. 9, Pages 2045: Effects of Bag Mask Ventilation and Advanced Airway Management on Adherence to Ventilation Recommendations and Chest Compression Fraction: A Prospective Randomized Simulator-Based Trial Journal of Clinical Medicine doi: 10.3390/jcm9072045 Authors: Lea Vogt Timur Sellmann Dietmar Wetzchewald Heidrun Schwager Sebastian Russo Stephan Marsch The role of advanced airway management (AAM) in cardiopulmonary resuscitation (CPR) is currently debated as...
Mon Jun 29, 2020 03:00
JCM, Vol. 9, Pages 2044: Effects of Trigger Point Dry Needling for the Management of Knee Pain Syndromes: A Systematic Review and Meta-Analysis Journal of Clinical Medicine doi: 10.3390/jcm9072044 Authors: Youssef Rahou-El-Bachiri Marcos J. Navarro-Santana Guido F Gómez‐Chiguano Cleland Villanueva Fernández‐de‐las‐Peñas Ortega‐Santiago Plaza‐Manzano Background: To evaluate the effect of trigger point dry needling alone or as an adjunct with other interventions...
Mon Jun 29, 2020 03:00
JCM, Vol. 9, Pages 2043: Antimycobacterial Effects of Everolimus in a Human Granuloma Model Journal of Clinical Medicine doi: 10.3390/jcm9072043 Authors: David Ashley Joshua Hernandez Ruoqiong Cao Kimberly To Aram Yegiazaryan Rachel Abrahem Timothy Nguyen James Owens Maria Lambros Selvakumar Subbian Vishwanath Venketaraman Mycobacterium tuberculosis (M. tb) has been historically and is currently a threat to global public health. First-line antibiotics have...
Mon Jun 29, 2020 03:00
JCM, Vol. 9, Pages 2046: High Prevalence of Sarcopenia in Older Trauma Patients: A Pilot Study Journal of Clinical Medicine doi: 10.3390/jcm9072046 Authors: Robert C. Stassen Kostan W. Reisinger Moaath Al-Ali Martijn Poeze Jan A. Ten Bosch Taco J. Blokhuis Sarcopenia is related to adverse outcomes in various populations. However, little is known about the prevalence of sarcopenia in polytrauma patients. Identifying the number of patients at risk of adverse outcome will...
Mon Jun 29, 2020 03:00
JCM, Vol. 9, Pages 2042: Gut Microbiota: Implications in Alzheimer’s Disease Journal of Clinical Medicine doi: 10.3390/jcm9072042 Authors: Yixi He Binyin Li Dingya Sun Shengdi Chen Alzheimer’s disease (AD), the most common cause of dementia, is a neurodegenerative disease that seriously threatens human health and life quality. The main pathological features of AD include the widespread deposition of amyloid-beta and neurofibrillary tangles in the brain. So far, the...
Mon Jun 29, 2020 03:00
JCM, Vol. 9, Pages 2040: Association of Systemic Comorbidities with Dry Eye Disease Journal of Clinical Medicine doi: 10.3390/jcm9072040 Authors: Motoko Kawashima Masakazu Yamada Chika Shigeyasu Kazuhisa Suwaki Miki Uchino Yoshimune Hiratsuka Norihiko Yokoi Kazuo Tsubota for the DECS-J for the DECS-J We investigated the association between dry eye disease and systemic comorbidities, including dry eye subtype, quality of life (QOL) and health utility among patients...
Mon Jun 29, 2020 03:00
JCM, Vol. 9, Pages 2041: Do Infants at Risk of Developing Cerebral Palsy or Other Neurodevelopmental Disorders Learn What They Practice? Journal of Clinical Medicine doi: 10.3390/jcm9072041 Authors: Kristina Löwing Linda Holmström Rita Almeida Ann-Christin Eliasson Through secondary analyses of the Small Step. Randomized Control Trial, we tested the hypothesis that children at risk of developing cerebral palsy (CP) or other neurodevelopmental disorders would learn what they...
Mon Jun 29, 2020 03:00
JCM, Vol. 9, Pages 2038: Does SARS-CoV-2 Trigger Stress-Induced Autoimmunity by Molecular Mimicry? A Hypothesis Journal of Clinical Medicine doi: 10.3390/jcm9072038 Authors: Francesco Cappello Antonella Marino Gammazza Dieli Everly Conway de Macario Macario Viruses can generate molecular mimicry phenomena within their hosts. Why shouldsevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) not be considered one of these?Information in this short review suggests that...
Mon Jun 29, 2020 03:00
JCM, Vol. 9, Pages 2039: Safety and Efficacy of Second Ahmed Valve Implant in Refractory Glaucoma Journal of Clinical Medicine doi: 10.3390/jcm9072039 Authors: Chiara Posarelli Mario Damiano Toro Robert Rejdak Tomasz Żarnowski Dorota Pożarowska Antonio Longo Mario Miccoli Marco Nardi Michele Figus Background: Refractory glaucoma still represents a challenge for ophthalmologists to manage intraocular pressure. The present study aimed to evaluate long term efficacy...
Mon Jun 29, 2020 03:00
JCM, Vol. 9, Pages 2036: Multimodal Approach to Assessment of Fecal Microbiota Donors based on Three Complementary Methods Journal of Clinical Medicine doi: 10.3390/jcm9072036 Authors: Jaroslaw Bilinski Mikolaj Dziurzynski Pawel Grzesiowski Edyta Podsiadly Anna Stelmaszczyk-Emmel Tomasz Dzieciatkowski Lukasz Dziewit Grzegorz W. Basak Methods of stool assessment are mostly focused on next-generation sequencing (NGS) or classical culturing, but only rarely both. We...
Mon Jun 29, 2020 03:00
JCM, Vol. 9, Pages 2037: The Role of Airways 17β-Estradiol as a Biomarker of Severity in Postmenopausal Asthma: A Pilot Study Journal of Clinical Medicine doi: 10.3390/jcm9072037 Authors: Scioscia Carpagnano Lacedonia Soccio Quarato Trabace Fuso Barbaro Background: Asthma severity differs according to gender; in adult women, there is higher prevalence and severity of asthma than in men, and it coincides with changes in sex hormones. Recently, a new phonotype...
Mon Jun 29, 2020 03:00
JCM, Vol. 9, Pages 2035: The Impact of Severe Maternal Morbidity on Perinatal Outcomes in High Income Countries: Systematic Review and Meta-Analysis Journal of Clinical Medicine doi: 10.3390/jcm9072035 Authors: Tesfaye S. Mengistu Jessica M. Turner Christopher Flatley Jane Fox Sailesh Kumar While there is clear evidence that severe maternal morbidity (SMM) contributes significantly to poor maternal health outcomes, limited data exist on its impact on perinatal outcomes. We...
Mon Jun 29, 2020 03:00
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