Candida albicans culture from a rectal swab can be associated with newly diagnosed colorectal cancer
Abstract Plenty of metagenomic studies have suggested possible associations between microbiome composition and colorectal cancer (CRC). However, these techniques are not economic enough for routine use so far. Therefore, we explored the possibility to detect species associated with colorectal cancer by conventional culture from rectal swab. Fifty-two patients newly diagnosed for adenoma/CRC and 52 age-matched controls were recruited and sampled. Rectal swabs were inoculated on...
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Abstract Blood–brain barrier (BBB) breakdown can disrupt nutrient supply and waste removal, which affects neuronal functioning. Currently, dynamic contrast-enhanced (DCE) MRI is the preferred in-vivo method to quantify BBB leakage. Dedicated DCE MRI studies in normal aging individuals are lacking, which could hamper value estimation and interpretation of leakage rate in pathological conditions. Therefore, we applied DCE MRI to investigate the association between BBB disruption...
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Publication date: Available online 29 June 2020Source: The Journal of Prosthetic DentistryAuthor(s): Modhupa Ghosh, Harsimran Kaur, Madhuri Dua, Aditi Nanda, Mahesh Verma
Publication date: Available online 29 June 2020Source: The Journal of Prosthetic DentistryAuthor(s): Tjitske Bannink, Shirley Bouman, Rene Wolterink, Robert van Veen, Maarten van Alphen
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Nature Communications, Published online: 29 June 2020; doi:10.1038/s41467-020-17081-zDefining the functions of individual organisms or communities within microbiomes is a challenging task. Here, the authors develop MetaRibo-Seq, a method for simultaneous high-throughput ribosome profiling of organisms in uncultured microbiome samples.
Nature Communications, Published online: 29 June 2020; doi:10.1038/s41467-020-17046-2Tumor-draining lymph nodes are often the first site of metastasis in breast cancer patients. Here, the authors show that metastatic lymph nodes are characterized by the accumulation of suppressive regulatory T cells with a distinct phenotype compared to matched non-invaded lymph nodes and tumors.
Nature Communications, Published online: 29 June 2020; doi:10.1038/s41467-020-17040-8The ability to culture live pancreatic tissue slices for long periods of time would enable longitudinal studies ex vivo. Here the authors culture human and mouse pancreatic slices in a perfluorocarbon-based culture system and show stable endocrine and exocrine function for up to ten days in culture.
Nature Communications, Published online: 29 June 2020; doi:10.1038/s41467-020-17085-9Catalytic reductive coupling of two electrophiles and one C = C bond is usually performed by two electron transfer metal catalysis. Herein, the authors show a visible light photoredox-catalyzed successive single electron transfer leading to dearomative arylcarboxylation of indoles with CO2 and generating indoline-3-carboxylic acids.
Nature Communications, Published online: 29 June 2020; doi:10.1038/s41467-020-16830-4While typical catalysts involve oxide-supported metals, inverse catalysts of oxides on metal supports offer an attractive alternative. Here, authors prepare FeOx-coated Rh nanoparticles via galvanic replacement and dissolution-precipitation to form effective CO2 reduction catalysts.
Nature Communications, Published online: 29 June 2020; doi:10.1038/s41467-020-16996-xLong distance interfaces between superconducting quantum information processing nodes would require coherent, efficient and low-noise microwave-to-optical conversion. Here, the authors use Yb ion ensembles in yttrium orthovanadate to demonstrate a transducer with the potential to fulfill these requirements.
Nature Communications, Published online: 29 June 2020; doi:10.1038/s41467-020-16958-3DNA is an attractive digital data storing medium due to high information density and longevity. Here the authors use millions of sequences to investigate inherent biases in DNA synthesis and PCR amplification.
Nature Communications, Published online: 29 June 2020; doi:10.1038/s41467-020-16923-0Restoration of coronary blood flow after a heart attack may lead to reperfusion injury and pathologic iron deposition. Here, the authors perform magnetic susceptibility imaging showing its association with iron in a large animal model of myocardial infarction during wound healing, and showing feasibility in acute myocardial infarction patients undergoing percutaneous coronary intervention.
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Abstract Background While magnetic resonance imaging (MRI) of the pelvis and hips is common in pediatric patients, to date there are no data on the quantification of normal hip joint fluid volume in this patient population. Objective We sought to assess the feasibility and reliability of quantitative hip joint fluid measurement in the pediatric population...
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Patients with novel corona virus infection (COVID-19) can develop acute respiratory failure secondary to acute respiratory distress syndrome. Cytokine storm is suggested as one of underlying mechanisms for the rapid clinical decline. Immunocompromised patients and cancer patients are at particular risk for poor outcomes due to COVID-19 infection. This case report describes the presentation and clinical course of a cancer survivor who became critically ill and required mechanical ventilation. The...
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Publication date: August 2020Source: Journal of Human Evolution, Volume 145Author(s): Sarah Elton, Jason Dunn
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